Dose-Dependent Inhibition of the Post-Prandial Glycaemic Response to a Standard Carbohydrate Meal following Incorporation of Alpha-CyclodextrinBuckley J.D. · Thorp A.A. · Murphy K.J. · Howe P.R.C.
Nutritional Physiology Research Centre, Australian Technology Network Centre for Metabolic Fitness, School of Health Sciences, University of South Australia, Adelaide, Australia
Do you have an account?
- Rent for 48h to view
- Buy Cloud Access for unlimited viewing via different devices
- Synchronizing in the ReadCube Cloud
- Printing and saving restrictions apply
Rental: USD 8.50
Cloud: USD 20.00
Article / Publication Details
Background: This study evaluated the dose-response effects of α-cyclodextrin, a cyclic oligosaccharide, on the glycaemic and insulinaemic responses to the consumption of a standard carbohydrate meal. Methods: In a double-blind, randomised, cross-over design, 10 healthy subjects consumed boiled white rice containing 50 g of digestible carbohydrate to which 0 (control), 2, 5 or 10 g of α-cyclodextrin was added. Plasma glucose and insulin concentrations were determined prior to and for 2 h after consumption of each meal. Results: The area under the plasma glucose curve was negatively related to the dose of α-cyclodextrin (r2 = 0.97, p = 0.02), with the areas being significantly reduced at the 5- and 10-gram doses compared with the control (p < 0.05). α-Cyclodextrin did not affect the area under the plasma insulin curve (p = 0.39). Higher doses of α-cyclodextrin resulted in greater satiety, but were associated with reduced palatability and an increased incidence of minor gastrointestinal complaints (stomach ache, nausea, bloating). Conclusion: α-Cyclodextrin reduces the glycaemic response to a standard carbohydrate meal in a dose-dependent manner and may be useful as an ingredient for reducing the glycaemic impact of such foods.
© 2006 S. Karger AG, Basel
- Augustin L, Galeone C, Dal Maso L, Pelucchi C, Ramazzotti V, Jenkins D, Montella M, Talamini R, Negri E, Franceschi S, La Vecchia C: Glycemic index, glycemic load and risk of prostate cancer. Int J Cancer 2004;112:446–450.
- Dickinson S, Brand-Miller J: Glycemic index, postprandial glycemia and cardiovascular disease. Curr Opin Lipidol 2005;16:69–75.
- Gerich J: Clinical significance, pathogenesis, and management of postprandial hyperglycemia. Arch Intern Med 2003;163:1306–1316.
- Hodge A, English D, O’Dea K, Giles G: Glycemic index and dietary fiber and the risk of type 2 diabetes. Diabetes Care 2004;27:2701–2706.
Silvera S, Jain M, Howe G, Miller A, Rohan T: Dietary carbohydrates and breast cancer risk: a prospective study of the roles of overall glycemic index and glycemic load. Int J Cancer 2004;17:DOI:10.1002/ijc.20796.
- Brand-Miller J: Glycemic load and chronic disease. Nutr Rev 2003;61:S49–S55.
- Frost G, Leeds A, Trew G, Margara R, Dornhorst A: Insulin sensitivity in women at risk of coronary heart disease and the effect of a low glycemic diet. Metabolism 1998;47:1245–1251.
- Opperman A, Venter C, Oosthuizen W, Thompson R, Vorster H: Meta-analysis of the health effects of using the glycaemic index in meal-planning. Br J Nutr 2004;92:367–381.
- Rizkalla S, Bellisle F, Slama G: Health benefits of low glycaemic index foods, such as pulses, in diabetic patients and healthy individuals. Br J Nutr 2002;88:S255–S262.
Roberts S, Pittas A: The role of glycemic index in type 2 diabetes. Nutr Clin Care 2003;6:73–78.
Brand-Miller JC, Holt SH, Pawlak DB, McMillan J: Glycemic index and obesity. Am J Clin Nutr 2002;76:S281–S285.
- Ludwig D: Dietary glycemic index and the regulation of body weight. Lipids 2003;38:117–121.
- Pawlak D, Kushner J, Ludwig D: Effects of dietary glycaemic index on adiposity, glucose homeostasis, and plasma lipids in animals. Lancet 2004;364:778–785.
- Biwer A, Antranikian G, Heinzle E: Enzymatic production of cyclodextrins. Appl Microbiol Biotechnol 2002;59:609–617.
Szejtli J: Chemistry, physical and biological properties of cyclodextrins; in Atwoods J, Lehm J-M (eds): Comprehensive Supramolecular Chemistry. Oxford, Pergamon, 1996, pp 5–40.
- van Ommen B, de Bie A, Bär A: Disposition of 14C-a-cyclodextrin in germ-free and conventional rats. Regul Toxicol Pharmacol 2004;39:S57–S66.
- Andersen G, Robbins F, Domingues F, Moores R, Long C: The utilization of Schardinger dextrins by the rat. Toxicol Appl Pharmacol 1963;5:257–266.
- Koukiekolo R, Desseaux V, Moreau Y, Marchis-Mouren G, Santimone M: Mechanism of porcine pancreatic a-amylase. Inhibition of amylose and maltopentaose hydrolysis by a-, β- and γ-cyclodextrins. Eur J Biochem 2001;268:841–848.
- Móra S, Simon I, Elödi P: Studies on the active center of pancreatic amylase. I. Binding of β-cyclodextrin. Mol Cell Biochem 1974;4:205–209.
- Raben A, Andersen K, Karberg M, Holst J, Astrup A: Acetylation of or beta-cyclodextrin addition to potato starch: beneficial effect on glucose metabolism and appetite sensations. Am J Clin Nutr 1997;66:304–314.
Diamantis I, Bär A: Effect of a-Cyclodextrin on the Glycemic Index (GI) and Insulinemic Index (II) of Starch in Healthy Human Volunteers. Munich, Wacker Chemie, 2002.
World Health Organisation: Joint FAO/WHO Expert Committee on Food Additives, 63rd meeting. Geneva, WHO, 2004.
Food Standards Australia and New Zealand: Final Assessment Report. Application A494. Alpha-Cyclodextrin as a Novel Food. Melbourne, FSANZ, 2004.
- Wolever T: Effect of blood sampling schedule and method of calculating the area under the curve on validity and precision of glycaemic index values. Br J Nutr 2004;91:295–300.
Read N: Small bowel transit time of food in man: measurement, regulation and possible importance. Scand J Gastroenterol 1984;96:77–85.
- Anderson G, Woodend D: Effect of glycemic carbohydrates on short-term satiety and food intake. Nutr Rev 2003;61:S17–S26.
Article / Publication Details
Copyright / Drug Dosage / DisclaimerCopyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.