Human Heredity
Original Paper
What Is the Significance of a Significant TDT?Ewens W.J.a · Spielman R.S.baDepartment of Biology and bDepartment of Genetics, University of Pennsylvania, Philadelphia, Pa., USA
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Article / Publication Details
Received: August 22, 2005
Accepted: November 07, 2005
Published online: February 03, 2006
Issue release date: February 2006
Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 2
ISSN: 0001-5652 (Print)
eISSN: 1423-0062 (Online)
For additional information: https://www.karger.com/HHE
Abstract
This note summarizes the development of the transmission/disequilibrium test (TDT). The initial purpose of the TDT procedure was to test for linkage between a genetic marker and a disease susceptibility locus when an association had been found between the two. An association between disease and marker had sometimes been taken to imply linkage. An association could, however, be due to population stratification even in the absence of linkage. In contrast, the outcome of the TDT is not affected by such stratification. Furthermore, when linkage is not in doubt, the TDT can, in some cases, also provide a test of association between marker and disease. We discuss these various matters in this paper.
© 2005 S. Karger AG, Basel
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References
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McGinnis RE, Spielman RS, Ewens WJ: Linkage between the insulin gene (IG) region and susceptibility to insulin-dependent diabetes mellitus (IDDM). Am J Hum Genet Suppl 1991;49:A476.
External Resources
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External Resources
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Article / Publication Details
Received: August 22, 2005
Accepted: November 07, 2005
Published online: February 03, 2006
Issue release date: February 2006
Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 2
ISSN: 0001-5652 (Print)
eISSN: 1423-0062 (Online)
For additional information: https://www.karger.com/HHE
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