Regulatory Mechanisms
Small non-coding RNAs and genomic imprintingRoyo H.a · Bortolin M.-L.a · Seitz H.b · Cavaillé J.aaLBME-CNRS, UMR 5099, IFR 109, Toulouse (France); bUMMS, Department of Biochemistry and Molecular Pharmacology, Lazare Research Building, Worcester, MA (USA)
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Cytogenet Genome Res 113:99–108 (2006)
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Article / Publication Details
First-Page Preview
Published online: March 30, 2006
Issue release date: March 2006
Number of Print Pages: 10
Number of Figures: 3
Number of Tables: 0
ISSN: 1424-8581 (Print)
eISSN: 1424-859X (Online)
For additional information: https://www.karger.com/CGR
Abstract
Experimental and computer-assisted approaches have led to the identification of hundreds of imprinted small RNA genes, mainly clustered in two chromosomal domains (human 15q11→q13 and 14q32 loci). The genes are only detected in placental mammals and belong to the C/D RNA and microRNA gene families. These are small non-coding RNAs involved in RNA-guided post-transcriptional RNA modifications and RNA-mediated gene silencing, respectively. Here, we discuss their potential functions and report the identification of novel small RNA genes lying within (or nearby) known imprinted chromosomal domains.
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Article / Publication Details
First-Page Preview
Published online: March 30, 2006
Issue release date: March 2006
Number of Print Pages: 10
Number of Figures: 3
Number of Tables: 0
ISSN: 1424-8581 (Print)
eISSN: 1424-859X (Online)
For additional information: https://www.karger.com/CGR
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Supported by grants from the European Union (CallimiR) and from the Ministère de l’Education Nationale, de la Recherche et de la Technologie (Action Concertée Incitative 2003: «Biologie cellulaire moléculaire et structurale»). Hervé Seitz thanks the Guillaume Canal’s foundation.
Bentwich et al. (2005) recently reported the characterization of many primate-specific microRNAs which are only detected in the placenta and whose genes are organized into a cluster at the human 19q13.4 domain, very close to three previously described miRNA genes (miR-371, miR-372 and miR-373) specifically expressed in human embryonic stem cells. This large cluster is reminiscent to some extent to that described at the human imprinted 14q32 locus (Cf. Fig. 2). Although these microRNA genes are located relatively far away from the paternally expressed
Many in silico-predicted microRNA genes at the imprinted
