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Human Disease

The Prader-Willi/Angelman imprinted domain and its control center

Kantor B. · Shemer R. · Razin A.

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Department of Cellular Biochemistry and Human Genetics, The Hebrew University-Hadassah Medical School, Jerusalem (Israel)

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Cytogenet Genome Res 113:300–305 (2006)

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Article / Publication Details

First-Page Preview
Abstract of Human Disease

Published online: March 30, 2006
Issue release date: March 2006

Number of Print Pages: 6
Number of Figures: 4
Number of Tables: 0

ISSN: 1424-8581 (Print)
eISSN: 1424-859X (Online)

For additional information: https://www.karger.com/CGR

Abstract

The present review focuses on the recent advances towards understanding the mode of operation of the imprinting center (IC) within the Prader-Willi/Angelman syndromes (PWS/AS) domain. Special emphasis is put on the elucidation of the functional interaction between the two parts of the center, AS-IC and PWS-IC. The recent studies, on which the review is based, reveal cis-acting elements and trans-acting proteins that constitute the two parts of the IC and presumably provide the molecular mechanism for this interaction. AS-IC acquires the primary imprint during gametogenesis by establishing the maternal epigenotype. The unmethylated maternal allele of the AS-IC binds, very likely, a trans-acting factor that confers methylation on the PWS-IC maternal allele after fertilization. It is assumed that the PWS-IC paternal epigenotype, once established, spreads across the entire PWS/AS domain in the soma.

© 2006 S. Karger AG, Basel


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Article / Publication Details

First-Page Preview
Abstract of Human Disease

Published online: March 30, 2006
Issue release date: March 2006

Number of Print Pages: 6
Number of Figures: 4
Number of Tables: 0

ISSN: 1424-8581 (Print)
eISSN: 1424-859X (Online)

For additional information: https://www.karger.com/CGR


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