Early Postnatal Growth
Size at Birth, Postnatal Growth and Risk of ObesityOng K.K.a, b
aMRC Epidemiology Unit, Strangeways Research Laboratory, Cambridge, and bDepartment of Paediatrics, University of Cambridge, Addenbrooke’s Hospital, Cambridge, UK
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Epidemiological studies over the last 15 years have shown that size at birth, early postnatal catch-up growth and excess childhood weight gain are associated with an increased risk of adult cardiovascular disease and type 2 diabetes. At the same time, rising rates of obesity and overweight in children, even at pre-school ages, have shifted efforts towards the identification of very early factors that predict risk of subsequent obesity, which may allow early targeted interventions. Overall, higher birth weight is positively associated with subsequent greater body mass index in childhood and later life; however, the relationship is complex. Higher birth weight is associated with greater subsequent lean mass, rather than fat mass. In contrast, lower birth weight is associated with a subsequent higher ratio of fat mass to lean mass, and greater central fat and insulin resistance. This paradoxical effect of lower birth weight is at least partly explained by the observation that infants who have been growth restrained in utero tend to gain weight more rapidly, or ‘catch up’, during the early postnatal period, which leads to increased central fat deposition. There is still debate as to whether there are critical early periods for obesity: does excess weight gain during infancy, childhood or even very early neonatal life have a greater impact on long-term fat deposition and insulin resistance? Early identification of childhood obesity risk will be aided by identification of maternal and fetal genes that regulate fetal nutrition and growth, and postnatal genes that regulate appetite, energy expenditure and the partitioning of energy intake into fat or lean tissue growth.
© 2006 S. Karger AG, Basel
Department of Health 2005 Health Survey for England: Obesity among children under 11, London, UK.
- Dietz WH: Overweight in childhood and adolescence. N Engl J Med 2004;350:855–857.
- Loos RJ, Beunen G, Fagard R, Derom C, Vlietinck R: Birth weight and body composition in young adult men – a prospective twin study. Int J Obes Relat Metab Disord 2001;25:1537–1545.
- Loos RJ, Beunen G, Fagard R, Derom C, Vlietinck R: Birth weight and body composition in young women: a prospective twin study. Am J Clin Nutr 2002;75:676–682.
- Hediger ML, Overpeck MD, Kuczmarski RJ, McGlynn A, Maurer KR, Davis WW: Muscularity and fatness of infants and young children born small- or large-for-gestational-age. Pediatrics 1998;102:E60.
- Gale CR, Martyn CN, Kellingray S, Eastell R, Cooper C: Intrauterine programming of adult body composition. J Clin Endocrinol Metab 2001;86:267–272.
- Law CM, Barker DJ, Osmond C, Fall CH, Simmonds SJ: Early growth and abdominal fatness in adult life. J Epidemiol Community Health 1992;46:184–186.
- Barker M, Robinson S, Osmond C, Barker DJ: Birth weight and body fat distribution in adolescent girls. Arch Dis Child 1997;77:381–383.
- Yajnik C: Interactions of perturbations in intrauterine growth and growth during childhood on the risk of adult-onset disease. Proc Nutr Soc 2000;59:257–265.
de Zegher F, Ong K, Dunger D, Ibáñez L: Along the path from fetal growth restraint to later diabetes: fat excess emerges by age 3 year. Horm Res 2005;64(suppl 1):183.
- Ong KK, Preece MA, Emmett PM, Ahmed ML, Dunger DB: Size at birth and early childhood growth in relation to maternal smoking, parity and infant breast-feeding: longitudinal birth cohort study and analysis. Pediatr Res 2002;52:863–867.
- Monteiro PO, Victora CG: Rapid growth in infancy and childhood and obesity in later life–a systematic review. Obes Rev 2005;6:143–154.
- Singhal A, Cole TJ, Lucas A: Early nutrition in preterm infants and later blood pressure: two cohorts after randomised trials. Lancet 2001;357:413–419.
- Singhal A, Fewtrell M, Cole TJ, Lucas A: Low nutrient intake and early growth for later insulin resistance in adolescents born preterm. Lancet 2003;361:1089–1097.
- Stunkard AJ, Berkowitz RI, Schoeller D, Maislin G, Stallings VA: Predictors of body size in the first 2 y of life: a high-risk study of human obesity. Int J Obes Relat Metab Disord 2004;28:503–513.
- Ong KK, Emmett PM, Noble S, Ness A, Dunger DB, the ALSPAC Study Team: Dietary energy intake at the age of 4 months predicts postnatal weight gain and childhood body mass index. Pediatrics 2006;117:e503–e508.
- Martin RM, Ness AR, Gunnell D, Emmett P, Davey Smith G: Does breast-feeding in infancy lower blood pressure in childhood? The Avon Longitudinal Study of Parents and Children (ALSPAC). Circulation 2004;109:1259–1266.
- Reilly JJ, Armstrong J, Dorosty AR, Emmett PM, Ness A, Rogers I, Steer C, Sherriff A: Early life risk factors for obesity in childhood: cohort study. BMJ 2005;330:1357.
- Vickers MH, Gluckman PD, Coveny AH, Hofman PL, Cutfield WS, Gertler A, Breier BH, Harris M: Neonatal leptin treatment reverses developmental programming. Endocrinology 2005;146:4211–4216.
- Yura S, Itoh H, Sagawa N, Yamamoto H, Masuzaki H, Nakao K, Kawamura M, Takemura M, Kakui K, Ogawa Y, Fujii S: Role of premature leptin surge in obesity resulting from intrauterine undernutrition. Cell Metab 2005;1:371–378.
- Farooqi IS, O’Rahilly S: New advances in the genetics of early onset obesity. Int J Obes (Lond) 2005;29:1149–1152.
- Stettler N, Stallings VA, Troxel AB, Zhao J, Schinnar R, Nelson SE, Ziegler EE, Strom BL: Weight gain in the first week of life and overweight in adulthood: a cohort study of European American subjects fed infant formula. Circulation 2005;111:1897–1903.
- Bhargava SK, Sachdev HS, Fall CH, Osmond C, Lakshmy R, Barker DJ, Biswas SK, Ramji S, Prabhakaran D, Reddy KS: Relation of serial changes in childhood body-mass index to impaired glucose tolerance in young adulthood. N Engl J Med 2004;350:865–875.
- Ekelund U, Ong K, Linné Y, Neovius M, Brage S, Dunger DB, Wareham NJ, Rössner S: Upward weight percentile crossing in infancy and early childhood independently predicts fat mass in young adults: the Stockholm Weight Development Study (SWEDES). Am J Clin Nutr 2006;83:324–330.
- Wells JC, Hallal PC, Wright A, Singhal A, Victora CG: Fetal, infant and childhood growth: relationships with body composition in Brazilian boys aged 9 years. Int J Obes (Lond) 2005;29:1192–1198.
- Berkowitz RI, Stallings VA, Maislin G, Stunkard AJ: Growth of children at high risk of obesity during the first 6 y of life: implications for prevention. Am J Clin Nutr 2005;81:140–146.
- Forsen T, Eriksson JG, Tuomilehto J, Teramo K, Osmond C, Barker DJ: Mother’s weight in pregnancy and coronary heart disease in a cohort of Finnish men: follow up study. BMJ 1997;315:837–840.
Catalano PM, Kirwan JP, Haugel-de Mouzon S, King J: Gestational diabetes and insulin resistance: role in short- and long-term implications for mother and fetus. J Nutr 2003;133:1674S–1683S.
- Sobngwi E, Boudou P, Mauvais-Jarvis F, Leblanc H, Velho G, Vexiau P, Porcher R, Hadjadj S, Pratley R, Tataranni PA, Calvo F, Gautier JF: Effect of a diabetic environment in utero on predisposition to type 2 diabetes. Lancet 2003;361:1861–1865.
- Hunter WA, Cundy T, Rabone D, Hofman PL, Harris M, Regan F, Robinson E, Cutfield WS: Insulin sensitivity in the offspring of women with type 1 and type 2 diabetes. Diabetes Care 2004;27:1148–1152.
- McCance DR, Pettitt DJ, Hanson RL, Jacobsson LT, Knowler WC, Bennett PH: Birth weight and non-insulin dependent diabetes: thrifty genotype, thrifty phenotype, or surviving small baby genotype? BMJ 1994;308:942–945.
- Victora CG, Barros FC, Horta BL, Martorell R: Short-term benefits of catch-up growth for small-for-gestational-age infants. Int J Epidemiol 2001;30:1325–1330.
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