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Other Neuroprotective Therapies on Trial in Acute Stroke

Ferro J.M.a · Dávalos A.b

Author affiliations

aDepartment of Neurosciences and Mental Health, Hospital de Santa Maria, Lisboa, Portugal, and bDepartment of Neurosciences, Hospital Universitari Germans Trias i Pujol, Badalona, Spain

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Cerebrovasc Dis 2006;21:127–130

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Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: May 04, 2006
Issue release date: May 2006

Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 0

ISSN: 1015-9770 (Print)
eISSN: 1421-9786 (Online)

For additional information: https://www.karger.com/CED

Abstract

New neuroprotective agents on trial may potentially offer benefit to stroke patients without the associated hemorrhagic risk of thrombolytic therapy. Clinical investigation of these drugs has been designed to obtain the highest probability of success, or concentrates on the salvageable ischemic brain and use infarct growth on MRI as a surrogate end-point. Nine substances in 10 trials are currently being tested in three therapeutical strategies in patients with acute ischemic stroke. These strategies focus on: (1) the optimal management of serum glucose with the infusion of glucose, insulin and potassium to induce and maintain euglycemia; (2) the modulation of the inflammatory response with recombinant human interferon-β1a, and (3) interfering with the ischemic cascade using magnesium, albumin, the metal iron chelator DP-b99, the AMPA receptor antagonist zonampanel, the serotonin agonists repinotan and piclozotan, the free radical scavenger cerovive, and the membrane modulator citicoline. Future directions should develop neuroprotective compounds that are safe and well tolerated, are effective in a broad range of patients and can be used with or without rt-PA.

© 2006 S. Karger AG, Basel


References

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Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: May 04, 2006
Issue release date: May 2006

Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 0

ISSN: 1015-9770 (Print)
eISSN: 1421-9786 (Online)

For additional information: https://www.karger.com/CED


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