Medical Principles and Practice
Case Report
Disseminated Penicillium marneffei Infection with Fungemia and Endobronchial Disease in an AIDS Patient in ChinaZhiyong Z.a · Mei K.b · Yanbin L.aaDepartment of Infectious Diseases and bLaboratory of Clinical Microbiology, West China Hospital,
Dr. Zong Zhiyong Department of Infectious Diseases, West China Hospital, Sichuan University Wainan Guoxuexiang 37, Chengdu 610041, Sichuan (People’s Republic of China) Tel. +86 28 8542 2641, Fax +86 28 8542 3212 E-Mail mishle333@yahoo.com.cn or zzy333@263.net |
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Abstract
Objective:To present a rare Chinese case ofdisseminated Penicilliummarneffei infection with fungemia and endobronchial disease in an AIDS patient. Clinical Presentation and Intervention: A 26-year-old policeman who had resided in Guangxi Province, China, for 3 years presented to his county hospital with a 2-month history of high fever and cough. A provisional diagnosis of pulmonary tuberculosis (TB) was made. Accordingly, the patient was treated with anti-TB drugs for 1 month but with no clinical improvement; he was then referred toWest China Hospital. Blood and bone marrow cultures as well as a bronchoscopic biopsy were positive for P. marneffei. A confirmatory serologic test for HIV was positive. A combination therapy with amphotericin B and itraconazole was instituted, and the patient responded well to treatment. Conclusion: This case showsendobronchial involvement caused by an emerging fungal microorganism. HIV-positive patients with a history of residence in or travel to southern China and a clinical presentation suggestive of TB but responding poorly to anti-TB treatment may have P. marneffei infection.
© 2006 S. Karger AG, Basel
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References
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Article / Publication Details
Received: February 06, 2005
Accepted: October 05, 2005
Published online: April 28, 2006
Issue release date: April 2006
Number of Print Pages: 3
Number of Figures: 1
Number of Tables: 0
ISSN: 1011-7571 (Print)
eISSN: 1423-0151 (Online)
For additional information: https://www.karger.com/MPP
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