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Contortrostatin, a Snake Venom Disintegrin with Anti-Angiogenic and Anti-Tumor Activity

Swenson S.a · Costa F.a · Ernst W.b · Fujii G.b · Markland F.S.a

Author affiliations

aUniversity of Southern California, Keck School of Medicine, and bMolecular Express, Inc., Los Angeles, Calif., USA

Corresponding Author

Francis S. Markland

University of Southern California, Keck School of Medicine

Cancer Research Laboratory #106, 1303 North Mission Road

Los Angeles, CA 90033 (USA)

Tel. +1 323 224 7981, Fax +1 323 224 7679, E-Mail markland@usc.edu

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Pathophysiol Haemos Thromb 2005;34:169–176

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Disintegrins are soluble peptides found in snake venom. They bind to Arg-Gly-Asp (RGD)-responsive integrins with high affinity (nM range) and block integrin function. Contortrostatin (CN), the disintegrin from southern copperhead venom, is a homodimer with a molecular weight of 13,500. Each chain contains 65 amino acids with an Arg-Gly-Asp motif. CN has anti-invasive and anti-adhesive activity on tumor cells and endothelial cells in vitro, and binds to integrins αvβ3, αvβ5, and/or α5β1. In vivo studies using the human metastatic breast cancer cell line MDA-MB-435, in an orthotopic xenograft model in nude mice, revealed that CN has potent anti-tumor and anti-angiogenic activity. Recent studies have employed an intravenous liposomal delivery procedure. Liposomal delivery of CN has also been shown to provide effective in vivo anti-tumor and anti-angiogenic activity in a human ovarian cancer animal model.

© 2005 S. Karger AG, Basel

Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: May 19, 2006
Issue release date: May 2006

Number of Print Pages: 8
Number of Figures: 2
Number of Tables: 0

ISSN: 1424-8832 (Print)
eISSN: 1424-8840 (Online)

For additional information: http://www.karger.com/PHT

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