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Cardiovascular Gap Junctions

Editor(s): Dhein S. (Leipzig) 
Cover

Alterations in Cardiac Connexin Expression in Cardiomyopathies

Severs N.a · Dupont E.a · Thomas N.a · Kaba R.a · Rothery S.a · Jain R.a · Sharpey K.a · Fry C.b

Author affiliations

aNational Heart and Lung Institute, Imperial College London, bInstitute of Urology and Nephrology, University College London, London, UK

Related Articles for ""

Dhein S (ed): Cardiovascular Gap Junctions. Adv Cardiol. Basel, Karger, 2006, vol 42, pp 228-242

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Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: March 31, 2006
Cover Date: 2006

Number of Print Pages: 15
Number of Figures: 0
Number of Tables: 0

ISBN: 978-3-8055-8077-9 (Print)
eISBN: 978-3-318-01317-7 (Online)

Abstract

Gap junctions, assembled from connexins, form the cell-to-cell pathways for propagation of the precisely orchestrated patterns of current flow that govern the synchronized rhythm of the healthy heart. As in most tissues and organs, multiple connexin types are co-expressed in the heart; the connexins Cx43, Cx40 and Cx45 are found in distinctive combinations and relative quantities in different, functionally specialized subsets of cardiomyocytes. Alterations in connexin expression and gap junction organization, now a well-documented feature of human cardiomyopathies, potentially contribute to the pro-arrhythmic substrate. In the diseased ventricle, the most consistently reported quantitative alteration involves heterogeneous reduction in Cx43 expression and disruption of the normal ordered pattern of Cx43 gap junction distribution. Additional studies suggest that upregulation of Cx40 and Cx45 may also feature in the failing ventricle, the former restricted to ischemic cardiomyopathy and localized to the subendocardial region. By correlating data from studies on the human patient with those from animal and cell models, alterations in connexin expression and gap junction organization have emerged as important factors to be considered in understanding the pro-arrhythmic substrate found in human cardiomyopathies.


Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: March 31, 2006
Cover Date: 2006

Number of Print Pages: 15
Number of Figures: 0
Number of Tables: 0

ISBN: 978-3-8055-8077-9 (Print)
eISBN: 978-3-318-01317-7 (Online)


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Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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