Original Research Article
Differences in Risk Factors for Dementia with Neurodegenerative Traits and for Vascular DementiaWehr H.a · Bednarska-Makaruk M.a · Łojkowska W.b · Graban A.b · Hoffman-Zacharska D.c · Kuczyńska-Zardzewiały A.d · Mrugała J.d · Rodo M.a · Bochyńska A.b · Sułek A.a · Ryglewicz D.b
aDepartment of Genetics and bFirst Department of Neurology, Institute of Psychiatry and Neurology, cDepartment of Neurogenetics, Clinic of Neurology, Epileptology and Sleep Disorders, Institute of Mother and Child, and dDepartment of Neurology, Wolski Hospital, Warsaw, Poland
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In 229 patients with dementia and in 144 control subjects, polymorphisms of apolipoprotein E (ApoE), low-density-lipoprotein (LDL)-receptor-related protein, α2-macroglobulin, interleukin (IL) 1β, angiotensin-converting enzyme and of methylene tetrahydrofolate reductase genes were investigated. In plasma, antibodies against Chlamydia pneumoniae and lipids were determined. Dementia was classified as probable Alzheimer’s disease (AD), probable dementia of vascular origin (VaD) and mixed dementia (MD). An association of the disease with ApoE and IL-1β polymorphism and increased levels of LDL cholesterol were observed in AD and in MD but not in VaD.
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Article / Publication Details
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