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Review

Progress in Discovery and Evaluation of Treatments to Prevent Bronchopulmonary Dysplasia

van Marter L.J.

Author affiliations

Children’s Hospital, Brigham and Women’s Hospital, Harvard Medical School, Boston, Mass., USA

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Biol Neonate 2006;89:303–312

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Article / Publication Details

First-Page Preview
Abstract of Review

Published online: June 14, 2006
Issue release date: June 2006

Number of Print Pages: 10
Number of Figures: 0
Number of Tables: 1

ISSN: 1661-7800 (Print)
eISSN: 1661-7819 (Online)

For additional information: https://www.karger.com/NEO

Abstract

Background: Recent improvements in the survival of extremely preterm infants have been accompanied by evolution in the pathogenesis and histopathology of bronchopulmonary dysplasia (BPD). Although oxygen and barotrauma-induced injury remain important contributing factors, pulmonary developmental arrest appears to play an equally important causal role in prolonged respiratory illness, especially among the most immature surviving preterm newborns. To date, clinical trials have failed to demonstrate a substantial benefit of a single treatment or preventive strategy for BPD. Objectives: To evaluate the current evidence in favor of treatments that might prevent BPD. Methods: Review of clinical studies of preventive treatment strategies for BPD. Results: High frequency oscillatory ventilation, permissive hypercapnea, and inhaled nitric oxide might offer benefit to infants at risk of BPD. These and other potential preventive therapies for BPD, such as superoxide dismutase, inositol, and α1-proteinase inhibitor, deserve further study. Conclusions: Although some current treatments offer promise, no preventive therapy for BPD has proven safe and effective, except for intramuscular vitamin A. Additional studies of respiratory technologies, management strategies, and protective molecules are needed.

© 2006 S. Karger AG, Basel


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Article / Publication Details

First-Page Preview
Abstract of Review

Published online: June 14, 2006
Issue release date: June 2006

Number of Print Pages: 10
Number of Figures: 0
Number of Tables: 1

ISSN: 1661-7800 (Print)
eISSN: 1661-7819 (Online)

For additional information: https://www.karger.com/NEO


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