Infection and Inflammation: Impacts on Oncogenesis

Editor(s): Dittmar, T. (Witten)
Zaenker, Kurt S. (Witten)
Schmidt, A. (Witten)

Specific Pathogens

Helicobacter pylori and Gastric Neoplasia

Leung W.

Author affiliations

Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, Hong Kong

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Dittmar T, Zaenker KS, Schmidt A (eds): Infection and Inflammation: Impacts on Oncogenesis. Contrib Microbiol. Basel, Karger, 2006, vol 13, pp 66-80

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Article / Publication Details

First-Page Preview
Abstract of Specific Pathogens

Published online: April 21, 2006
Cover Date: 2006

Number of Print Pages: 15
Number of Figures: 0
Number of Tables: 0

ISBN: 978-3-8055-8064-9 (Print)
eISBN: 978-3-318-01310-8 (Online)

Abstract

Helicobacter pylori is present in the stomach of more than half of the world population. Based on compelling epidemiological evidences, it was classified by the World Health Organization as a type I gastric carcinogen. It is generally believed that gastric cancer development is a multi-step progression from chronic gastritis to atrophy, intestinal metaplasia, dysplasia, and cancer. Individuals infected with H. pylori have at least a 2-fold increase in risk of gastric cancer development though only a small proportion of infected individuals will ultimately develop this malignancy. The exact mechanisms underlying how H. pylori triggers or causes gastric cancer remain elusive. Certain H. pylori genotypes like cagA, vacA s1 or babA1 are considered to be of higher virulent potential. Apart from the bacterial factors, the host response to chronic H. pylori infection may also attribute to the cancer risk. It was found that individuals who carry pro-inflammatory cytokine gene polymorphism have a substantial increase in risk of cancer development. The combination of bacterial and host genotypes may have a synergistic effect on cancer development. Despite the strong causal link between chronic H. pylori infection and gastric cancer, the role of H. pylori eradication in preventing gastric cancer remains controversial. More long-term data may be necessary to clarify this controversy.




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Article / Publication Details

First-Page Preview
Abstract of Specific Pathogens

Published online: April 21, 2006
Cover Date: 2006

Number of Print Pages: 15
Number of Figures: 0
Number of Tables: 0

ISBN: 978-3-8055-8064-9 (Print)
eISBN: 978-3-318-01310-8 (Online)


Copyright / Drug Dosage / Disclaimer

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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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