European Neurology

Original Paper

Neuropsychological Changes in Patients with Carotid Stenosis after Carotid Endarterectomy

Fukunaga S.a, b, d · Okada Y.b · Inoue T.c · Hattori F.d · Hirata K.a

Author affiliations

aDepartment of Neurology, Dokkyo University School of Medicine, Tochigi, Departments of bCerebrovascular Disease, and cNeurosurgery, National Kyushu Medical Center, and dNagao Hospital, Fukuoka, Japan

Keywords: Carotid endarterectomyWisconsin Card Sorting TestFrontal lobe functionCerebral perfusion reserveCarotid stenosis

Related Articles for ""
Eur Neurol 2006;55:145–150
https://doi.org/10.1159/000093214

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: January 18, 2006
Accepted: March 15, 2006
Published online: June 23, 2006
Issue release date: June 2006

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 7

ISSN: 0014-3022 (Print)
eISSN: 1421-9913 (Online)

For additional information: https://www.karger.com/ENE

Abstract

We investigated changes in neuropsychological function in patients with carotid stenosis following carotid endarterectomy (CEA) in relation to cerebral hemodynamics. The subjects were 24 patients who underwent CEA and 17 healthy controls matched by age, educational level, gender and handedness. Cerebral angiography, single-photon emission computed tomography (SPECT) and neuropsychological tests were performed approximately 1 week before and 3 weeks after CEA in all patients. In the patient group, the categories achieved in the new modified Wisconsin Card Sorting Test (WCST) improved significantly after CEA (4.0 ± 2.0; before CEA: 2.3 ± 2.1, p < 0.01). The perseverative errors of Nelson in the WCST improved significantly (before CEA: 9.1 ± 6.9, after CEA: 3.3 ± 3.4, p < 0.01). The difficulty maintaining set in the WCST improved significantly (before CEA: 2.3 ± 1.9, after CEA: 1.3 ± 1.7, p < 0.05). In the control group, none of the test scores showed significant improvement between the first and second tests. Moreover, frontal lobe function improved significantly in those patients with baseline carotid artery diameter of more than 70% of normal, or whose preoperative cerebral perfusion reserve was reduced by less than 15% of a response to acetazolamide. Our results suggest that CEA improves frontal lobe function in patients with severe carotid stenosis or reduced cerebral perfusion reserve.

© 2006 S. Karger AG, Basel



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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: January 18, 2006
Accepted: March 15, 2006
Published online: June 23, 2006
Issue release date: June 2006

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 7

ISSN: 0014-3022 (Print)
eISSN: 1421-9913 (Online)

For additional information: https://www.karger.com/ENE

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2006, Vol.55, No. 3

June 2006

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