European Neurology
Original Paper
Perception of Emotional Facial Expressions at Different Intensities in Early-Symptomatic Huntington’s DiseaseMontagne B.a, b · Kessels R.P.C.a, c · Kammers M.P.M.a · Kingma E.d · de Haan E.H.F.a, b · Roos R.A.C.d · Middelkoop H.A.M.d, eaPsychological Laboratory, Helmholtz Instituut, Utrecht University, Utrecht; bDepartment of Psychiatry, Radboud University Nijmegen Medical Centre, Nijmegen; cDepartment of Neurology, University Medical Centre Utrecht, Utrecht; dDepartment of Neurology, Leiden University Medical Centre, Leiden, and eDepartment of Neuropsychology, Faculty of Social Sciences, Leiden University, Leiden, The Netherlands
|
|
Log in to MyKarger to check if you already have access to this content.
KAB
Buy a Karger Article Bundle (KAB) and profit from a discount!
If you would like to redeem your KAB credit, please log in.
Save over 20% compared to the individual article price.
Article / Publication Details
Received: February 01, 2006
Accepted: March 22, 2006
Published online: June 23, 2006
Issue release date: June 2006
Number of Print Pages: 4
Number of Figures: 1
Number of Tables: 0
ISSN: 0014-3022 (Print)
eISSN: 1421-9913 (Online)
For additional information: https://www.karger.com/ENE
Abstract
Background: While there is abundant evidence that patients with Huntington’s disease (HD) have an impairment in the recognition of the emotional facial expression of disgust, previous studies have only examined emotion perception using full-blown facial expressions. Objective: The current study examines the perception of facial emotional expressions in HD at different levels of intensity to investigate whether more subtle deficits can be detected, possible also in other emotions. Method: We compared early symptomatic HD patients with healthy matched controls on emotion perception, presenting short video clips of a neutral face changing into one of the six basic emotions (happiness, anger, fear, surprise, disgust and sadness) with increasing intensity. Overall face perception ability as well as depressive symptoms were taken into account. Results: A specific impairment in recognizing the emotions disgust and anger was found, which was present even at low emotion intensities. Conclusion: These results extend previous findings and support the use of more sensitive emotion perception paradigms, which enable the detection of subtle neurobehavioral deficits even in the pre- and early symptomatic stages of the disease.
© 2006 S. Karger AG, Basel
Related Articles:
References
- Gutekunst C, Norflus F, Hersch SM: Recent advances in Huntington’s disease. Curr Opin Neurol 2000;13:445–450.
- Craufurd D, Thompson JC, Snowden JS: Behavioral changes in Huntington Disease. Neuropsychiatry Neuropsychol Behav Neurol 2001;14:219–226.
- Sprengelmeyer R, Young AW, Calder AJ, Karnat A, Lange H, Homberg V, Perrett DI, Rowland D: Loss of disgust: perception of faces and emotions in Huntington’s disease. Brain 1996;119:1647–1665.
- Speedie LJ, Brake N, Folstein SE, Bowers D, Heilman KM: Comprehension of prosody in Huntington’s disease. J Neurol Neurosurg Psychiatry 1990;53:607–610.
- Halligan PW: Inability to recognise disgust in Huntington’s disease. Lancet 1998;351:464.
- Gray JM, Young AW, Barker WA, Curtis A, Gibson D: Impaired recognition of disgust in Huntington’s disease gene carriers. Brain 1997;120:2029–2038.
- Milders M, Crawford JR, Lamb A, Simpson SA: Differential deficits in expression recognition in gene-carriers and patients with Huntington’s disease. Neuropsychologia 2003;41:1484–1492.
-
Sprengelmeyer R, Young AW, Sprengelmeyer A, Calder AJ, Rowland D, Perrett D, Hömberg V, Lange H: Recognition of facial expressions: selective impairment of specific emotions in Huntington’s disease. Cogn Neuropsychol 1997;14:839–879.
External Resources
- Sprengelmeyer R, Schroeder U, Young AW, Epplen JT: Disgust in pre-clinical Huntington’s disease: a longitudinal study. Neuropsychologia 2006;44:518–533.
- Lough S, Kipps CM, Treise C, Watson P, Blair JR, Hodges JR: Social reasoning, emotion and empathy in frontotemporal dementia. Neuropsychologia 2006;44:950–958.
- Hennenlotter A, Schroeder U, Erhard P, Haslinger B, Stahl R, Weindl A, Von Einsiedel HG, Lange KW, Ceballos-Baumann AO: Neural correlates associated with impaired disgust processing in pre-symptomatic Huntington’s disease. Brain 2004;127:1446–1453.
- Wang K, Hoosain R, Yang RM, Meng Y, Wang CQ: Impairment of recognition of disgust in Chinese with Huntington’s or Wilson’s disease. Neuropsychologia 2003;41:527–537.
-
Ekman P, Friesen WV: Unmasking the Face. Englewood Cliffs, Prentice Hall, 1975.
-
American Psychiatric Association: Diagnostic and Statistical Manual of Mental Disorders, ed 4. Washington, APA, 1994.
-
Lezak MD, Howieson DB, Loring DW: Neuropsychological Assessment, ed 4. New York, Oxford University Press, 2004.
-
Montagne B, Kessels RPC, Wester AJ, De Haan EHF: Processing of emotional facial expressions in Korsakoff’s syndrome. Cortex 2006, in press.
-
Benson PJ, Perrett DI: Synthesising continuous-tone caricatures. Image Vis Comput 1991;9:123–129.
External Resources
-
Russell JA, Fehr B: Relativity in the perception of emotion in facial expressions. J Exp Psychol Gen 1987;116:223–237.
External Resources
- Calder AJ, Keane J, Lawrence AD, Manes F: Impaired recognition of anger following damage to the ventral striatum. Brain 2003;127:1958–1969.
- Peinemann A, Schuller S, Pohl C, Jahn T, Weindl A, Kassubek J: Executive dysfunction in early stages of Huntington’s disease is associated with striatal and insular atrophy: a neuropsychological and voxel-based morphometric study. J Neurol Sci 2005;239:11–19.
Article / Publication Details
Received: February 01, 2006
Accepted: March 22, 2006
Published online: June 23, 2006
Issue release date: June 2006
Number of Print Pages: 4
Number of Figures: 1
Number of Tables: 0
ISSN: 0014-3022 (Print)
eISSN: 1421-9913 (Online)
For additional information: https://www.karger.com/ENE
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
Get Permission
PubMed ID
