Login to MyKarger

New to MyKarger? Click here to sign up.



Login with Facebook

Forgot your password?

Authors, Editors, Reviewers

For Manuscript Submission, Check or Review Login please go to Submission Websites List.

Submission Websites List

Institutional Login
(Shibboleth or Open Athens)

For the academic login, please select your country in the dropdown list. You will be redirected to verify your credentials.

Original Research

Non-Invasive Resting Magnetocardiographic Imaging for the Rapid Detection of Ischemia in Subjects Presenting with Chest Pain

Tolstrup K.a · Madsen B.E.b · Ruiz J.A.a · Greenwood S.D.a · Camacho J.a · Siegel R.J.a · Gertzen H.C.b · Park J.-W.c · Smars P.A.b

Author affiliations

aCedars-Sinai Medical Center, Division of Cardiology, Los Angeles, Calif., and bMayo Clinic College of Medicine, Department of Emergency Medicine, Rochester, Minn., USA; cKlinikum Hoyerswerda, Division of Cardiology, Hoyerswerda, Germany

Related Articles for ""

Cardiology 2006;106:270–276

Do you have an account?

Login Information





Contact Information










I have read the Karger Terms and Conditions and agree.



Login Information





Contact Information










I have read the Karger Terms and Conditions and agree.



To view the fulltext, please log in

To view the pdf, please log in

Buy

  • FullText & PDF
  • Unlimited re-access via MyKarger
  • Unrestricted printing, no saving restrictions for personal use
read more

CHF 38.00 *
EUR 35.00 *
USD 39.00 *

Select

KAB

Buy a Karger Article Bundle (KAB) and profit from a discount!

If you would like to redeem your KAB credit, please log in.


Save over 20% compared to the individual article price.
Learn more

Rent/Cloud

  • Rent for 48h to view
  • Buy Cloud Access for unlimited viewing via different devices
  • Synchronizing in the ReadCube Cloud
  • Printing and saving restrictions apply

Rental: USD 8.50
Cloud: USD 20.00


Select

Subscribe

  • Access to all articles of the subscribed year(s) guaranteed for 5 years
  • Unlimited re-access via Subscriber Login or MyKarger
  • Unrestricted printing, no saving restrictions for personal use
read more

Subcription rates


Select

* The final prices may differ from the prices shown due to specifics of VAT rules.

Article / Publication Details

First-Page Preview
Abstract of Original Research

Received: August 11, 2005
Accepted: February 28, 2006
Published online: November 15, 2006
Issue release date: November 2006

Number of Print Pages: 7
Number of Figures: 3
Number of Tables: 3

ISSN: 0008-6312 (Print)
eISSN: 1421-9751 (Online)

For additional information: https://www.karger.com/CRD

Abstract

Background: Early diagnosis of ischemia is complicated by the poor sensitivity of standard tests and contraindication for stress testing in unstable angina patients. Magnetocardiography (MCG) imaging can be used for the rapid, non-invasive detection of ischemia at rest. Methods: We studied 125 patients with presumed ischemic chest pain. All were chest pain free at the time of scanning. A 6-minute resting MCG scan (CardioMag Imaging, Inc., New York, 9-channel system) was performed. Following the MCG scan, automated software data analysis was performed, and quantitative scores were automatically calculated for each subject. The presence of ischemia was determined after testing with serial troponins, stress testing, and/or coronary angiography. Results: The mean age was 59.4 ± 13.6 years. Most patients (86.4%) had non-ischemic 12-lead ECG and normal troponin (86.2%). Fifty-five patients (44.0%) were determined to be ischemic. The MCG sensitivity, specificity, positive and negative predictive value was 76.4, 74.3, 70.0 and 80.0%, respectively, for the detection of ischemia (p < 0.0001). Conclusions: MCG is a new rapid, non-invasive imaging tool able to detect repolarization abnormalities at rest consistent with ischemia in patients presenting with chest pain syndrome and normal or non-specific 12-lead ECG and normal troponin.

© 2006 S. Karger AG, Basel


References

  1. Gibbons RJ, Abrams J, Chatterjee K, et al: ACC/AHA 2002 guideline update for the management of patients with chronic stable angina: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee to Update the 1999 Guidelines for the Management of Patients with Chronic Stable Angina), 2002.
  2. Stroink G, Moshage W, Achenbach S: Cardiomagnetism; in Andrä W, Nowak H (eds): Magnetism in Medicine. Berlin GmbH, WILEY-VCH Verlag, 1998, pp 136–189.
  3. Cohen D, Edelsack EA, Zimmerman JE: Magnetocardiograms taken inside a shielded room with a superconducting point-contact magnetometer. Appl Phys Lett 1970;16:278–280.
    External Resources
  4. Nakaya Y, Sumi M, Saito K, Fujino K, Murakami M, Mori H: Analysis of current source of the heart using isomagnetic and vector arrow maps. Jpn Heart J 1984:25:701–711.
  5. Kobayashi K, Uchikawa Y: Frequency analysis of premature ventricular contraction using 3-D MCG measurements. IEEE Trans Magn 1999;35:4112–4114.
  6. Brisinda D, Fenici R: Noninvasive localization of ventricular preexcitation: role of multichannel magnetocardiography. Proceedings of 12th International Conference on Biomagnetism. 2000, pp 560–562.
  7. Korhonen P, Montonen J, Makijarvi T, Katila T, Nieminen MS, Toivonen L: Late fields of the magnetocardiographic QRS complex as indicators of propensity to sustained ventricular tachycardia after myocardial infarction. J Cardiovasc Electrophys 2000;11:413–420.
  8. Agren PL, Goranson H, Hindmarsh T, et al: Magnetocardiographic localization of arrhythmia substrates: a methodology study with accessory pathway ablation as reference. IEEE Trans Med Imaging 1998;17:479–484.
  9. Kobayashi K, Uchikawa Y, Nakai K, Yoshizawa M: Analysis of excitation conduction with WPW syndrome patients using a three-dimensional magnetocardiogram. Proceedings of 13th International Conference on Biomagnetism. 2002, pp 573–575.
  10. Yamada S, Tsudaka K, Miyashita T, et al: Analysis of more complex arrhythmias using the tangential components of the cardiac magnetic field. Proceedings of 12th International Conference on Biomagnetism. 2000, pp 573–575.
  11. Yamada S, Tsudaka K, Miyashita T, Wan K, Yamaguchi I: Noninvasive stratification of micro-entrant arrhythmia by using magnetocardiograms. Proceedings of 13th International Conference on Biomagnetism. 2002, pp 554–556.
  12. Van Leeuwen P, Hailer B, Lange S, Donker D, Grönemeier D: Spatial and temporal changes during the QT-interval in the magnetic field of patients with coronary artery disease. Biomed Tech 1999;44:139–142.
    External Resources
  13. Chaikovsky I, Kohler J, Hecker Th, et al: Detection of coronary artery disease in patients with normal or unspecifically changed ECG on the basis of magnetocardiography. Proceedings of 12th International Conference on Biomagnetism. 2000.
  14. Sato M, Terada Y, Mitsui T, Miyashita T, Kandori A, Tsukada K: Detection of myocardial ischemia by magnetocardiogram using 64-channel SQUID system. Proceedings of 12th International Conference on Biomagnetism. 2001.
  15. Chen J, Thompson PD, Nolan V, Clarke J, Bakharev A: The normal magnetocardiogram at rest and post-exercise in healthy volunteers in an unshielded clinical environment. Proceedings of 13th International Conference on Biomagnetism. 2002, p 533.
  16. Sternickel K, Tralshawala N, Bakharev A, et al: Unshielded measurements of cardiac electrical activity using magnetocardiography. 4th International Conference on Bioelectromagnetism 2002, pp 188–190.
  17. Brazdeikis A, Taylor AA, Mahmarian JJ, Xue Y, Chu CW: Comparison of magnetocardiograms acquired in unshielded clinical environment at rest, during and after exercise and in conjunction with myocardial perfusion imaging. Proceedings of 13th International Conference on Biomagnetism. 2002, pp 530–532.
  18. Fenici R, Brisinda D, Nenonen J, Mäkijärvi M, Fenici P: Study of ventricular repolarization in patients with myocardial ischemia, using unshielded multichannel magnetocardiography. Proceedings of 13th International Conference on Biomagnetism. 2002, pp 537–539.
  19. Sternickel K: Breathing artifact removal from MCG time series. Proceedings of 12th International Conference on Biomagnetism. 2000, p 1050.
  20. Steinberg BA, Roguin A, Watkins SP 3rd, Hill P, Fernando D, Resar JR: Magnetocardiogram recordings in a nonshielded environment – reproducibility and ischemia detection. Ann Noninvasive Electrocardiol 2005;10:152–160.
  21. Grundy S, Becker D, Clark LT, Cooper RS, Denke MA, Howard J, et al: Third Report of the National Cholesterol Education Program Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III). National Institute of Health, 2002, pp 1–284.
  22. Alexander A: Bakharev, 2001 PCT Application Based on U.S. Prov. Appl. No.: 60/228,640. Title: Ischemia Identification, Quantification and partial Localization in MCG.
  23. Chaikovsky I, Primin M, Nedayvoda I, Vassylyev V, Sosnitsky V, Steinberg F: Computerized classification of patients with coronary artery disease but normal or unspecifically changed ECG and healthy volunteers. Proceedings of 13th International Conference on Biomagnetism. 2002, pp 534–536.
  24. Hailer B, Van Leeuwen P, Klein A, et al: Magnetocardiographic changes in the course of coronary intervention. Proceedings of 13th International Conference on Biomagnetism. 2002, pp 541–543.
  25. Plonsey R: Comparative capabilities of electrocardiography and magnetocardiography. Am J Cardiol 1972;29:735–736.
  26. Hänninen H, Takala P, Mäkijärvi M, et al: Detection of exercise-induced myocardial ischemia by multichannel magnetocardiography in single vessel coronary artery disease. Ann Noninvasive Electrocardiol 2000;5:147–157.
    External Resources
  27. Hänninen H, Takala P, Korhonen P, et al: Features of ST segment and T-wave in exercise-induced myocardial ischemia evaluated with multichannel magnetocardiography. Ann Med 2002;34:120–129.

Article / Publication Details

First-Page Preview
Abstract of Original Research

Received: August 11, 2005
Accepted: February 28, 2006
Published online: November 15, 2006
Issue release date: November 2006

Number of Print Pages: 7
Number of Figures: 3
Number of Tables: 3

ISSN: 0008-6312 (Print)
eISSN: 1421-9751 (Online)

For additional information: https://www.karger.com/CRD


Copyright / Drug Dosage / Disclaimer

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.