Immunoregulatory T Cells in the Peripheral Blood of Patients with Hodgkin’s LymphomaBaráth S.a · Aleksza M.a · Keresztes K.a · Tóth J.b · Sipka S.a · Szegedi G.c · Illés Á.a
aThird Department of Internal Medicine, Institute of Internal Medicine, Medical and Health Science Center, University of Debrecen, bDepartment of Oncology, Medical and Health Science Center, University of Debrecen, and cResearch Group of Autoimmune Diseases, Hungarian Academy of Sciences, Debrecen, Hungary
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Article / Publication Details
We aimed at investigating the distribution of various types of immunoregulatory T cells in the peripheral blood of patients with Hodgkin’s lymphoma (HL) (n = 94) being in the state of long-lasting complete remission using flow cytometry. Healthy patients (n = 41) as ‘negative’ and patients in complete remission with breast cancer (n = 47) as ‘positive’ controls were investigated in the study. We found significant elevations in the number of CD4+CD25high naturally occurring regulatory T cells, CD4+/intracellular IL-10+ (Tr1) and CD8+/intracellular IL-10+ T cells in HL compared to the healthy controls. In carcinoma patients, however, the number of Tr1 and CD8+/IL-10+ T cells was higher than that in the other two groups. The increase in the number of CD4+CD25high T cells seems to be characteristic of HL compared to the two other types of regulatory T cells. This change exists for a long time and it seems to be a characteristic of HL and independent of the types of therapy and the duration of time since therapy.
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