Dementia and Geriatric Cognitive Disorders

Original Research Article

Regional Quantification of White Matter Hyperintensity in Normal Aging, Mild Cognitive Impairment, and Alzheimer’s Disease

Chen Y.-F.a, b · Wang H.a, c · Chu Y.a · Huang Y.-C.a, d · Su M.-Y.a

Author affiliations

aTu and Yuen Center for Functional Onco-Imaging, University of California, Irvine, Calif., USA; bDepartment of Medical Imaging, National Taiwan University Hospital, Taipei, Taiwan; cDepartment of Geriatric Psychiatry, Peking University Institute of Mental Health, Beijing, China; dDepartment of Radiology, Cathay General Hospital, Taipei, Taiwan

Keywords: Alzheimer’s diseaseBrain agingCognitive testsMagnetic resonance imagingMild cognitive impairmentWhite matter lesions

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Dement Geriatr Cogn Disord 2006;22:177–184
https://doi.org/10.1159/000094785

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Article / Publication Details

First-Page Preview
Abstract of Original Research Article

Received: March 21, 2006
Published online: August 18, 2006
Issue release date: August 2006

Number of Print Pages: 8
Number of Figures: 4
Number of Tables: 3

ISSN: 1420-8008 (Print)
eISSN: 1421-9824 (Online)

For additional information: https://www.karger.com/DEM

Abstract

Background/Aims: A quantitative method was applied to measure the volume of white matter hyperintensity (WMH) in different brain regions of subjects with Alzheimer’s disease (AD), mild cognitive impairment (MCI) and normal healthy age-matched controls, and the relationship between regional WMH and age and cognitive function was investigated. Methods: Fifty-six subjects were included in this study, 27 AD, 15 MCI and 14 normal age-matched controls. A user-friendly software was developed for WMH quantification in frontal, temporal, and parieto-occipital lobes. Mini-Mental State Examination and cognitive scores in performing naming, language fluency, and memory tasks were obtained for correlation analysis. Results: AD patients had the greatest total WMH volume, followed by MCI, then controls. However, there was a large variation within each group, and the difference did not reach a significant level. There was a positive linear correlation between the total WMH (p = 0.031) and the frontal WMH (p = 0.006) vs. age. After age correction the Boston Naming Test scores were negatively correlated with the total WMH volume in the AD (p = 0.03) and the control (p = 0.03) groups, and with the frontal WMH in controls (p = 0.01). Conclusion: We demonstrated a quantitative analysis method to measure regional WMH. Although WMH was not strongly associated with disease severity or cognition, it may provide a characteristic neuroimaging parameter in the study of AD development.

© 2006 S. Karger AG, Basel



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Article / Publication Details

First-Page Preview
Abstract of Original Research Article

Received: March 21, 2006
Published online: August 18, 2006
Issue release date: August 2006

Number of Print Pages: 8
Number of Figures: 4
Number of Tables: 3

ISSN: 1420-8008 (Print)
eISSN: 1421-9824 (Online)

For additional information: https://www.karger.com/DEM

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2006, Vol.22, No. 2

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