Urologia Internationalis
Original Paper
Upper Urothelial Tumors in Emigrants from Balkan Endemic Nephropathy Areas in SerbiaNikolic J.a · Djokic M.a · Ignjatovic I.b · Stefanovic V.caClinic of Urology, Institute of Urology and Nephrology, Clinical Center of Serbia, Belgrade, bClinic of Urology and cInstitute of Nephrology and Hemodialysis, Clinical Center, Nis, Serbia
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Article / Publication Details
Received: June 24, 2005
Accepted: April 26, 2006
Published online: October 11, 2006
Issue release date: October 2006
Number of Print Pages: 5
Number of Figures: 1
Number of Tables: 5
ISSN: 0042-1138 (Print)
eISSN: 1423-0399 (Online)
For additional information: https://www.karger.com/UIN
Abstract
Aim: The aim of the study was to investigate upper urothelial tumors (UUT) in emigrants from Balkan endemic nephropathy (BEN) areas in Serbia and compare them with UUT from both endemic and nonendemic areas. Materials and Methods: A total of 1,121 patients from the state cancer database, between 1960 and 1998, were investigated. Sixty of them were emigrants from BEN areas. Results: UUT in emigrants from BEN areas occurred after 21.7 ± 9.9 years (median 20) spent in a rural environment. The time spent outside of the BEN regions was 33.2 ± 12.8 years (median 31, range 10–72). Age at surgery was 55 years (range 31–89). In emigrants from BEN areas, there was a significant association of other diseases with UUT: renal failure in 63%, bladder tumors in 23.3% and bilateralism in 6.7% of the patients. Bilateralism was statistically more frequent in emigrants from BEN areas (p = 0.04), as were low-grade tumors (p = 0.03). There was no statistical difference in tumor stage between patients from BEN areas and from outside of them. Relatives of the emigrants from BEN areas were also affected by BEN, UUT and both of them (33%). Conclusions: It is concluded that hereditary as well as environmental factors are important for the expression and evolution of the disease. An early period of life spent in the endemic region seems important for the later development of UUT in emigrants from BEN regions. Different time spans spent in the endemic region have no effect on the age of appearance of UUT.
© 2006 S. Karger AG, Basel
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References
- Stefanovic V: Balkan endemic nephropathy: a need for novel aetiological approaches. Quart J Med 1998;91:457–463.
-
Stefanovic V: Balkan endemic nephropathy: a reappraisal after forty years. Facta Universitatis 1999;6:53–58.
-
Carroll RP: Urothelial carcinoma: cancers of the bladder, ureter and renal pelvis; in Tanagho E, McAninch WJ (eds): Smith’s General Urology. New York, McGraw Hill, 2000, pp 355–377.
-
Naumovic T, Stamenkovic M, Joksimovic L, Velimirovic D: Frequency of endemic nephropathy and tumors of the urothelium in the Kolubara region; in Strahinjic S, Stefanovic V (eds): Current Research in Endemic (Balkan) Nephropathy. Nis, University Press, 1983, pp 269–276.
-
Cukuranovic R, Ignjatovic M, Stefanovic V: Urinary tract tumors and Balkan nephropathy in the South Morava river basin. Kidney Int Suppl 1991;40:S80–S84.
External Resources
-
Nikolic J, Popovic J: Tumors of the pelvis and ureter in emigrants from endemic nephropathy areas; in Strahinjic S, Stefanovic V (eds): Current Research in Endemic (Balkan) Nephropathy. Nis, University Press, 1983, pp 105–108.
-
Dinev IV: Results of long-term observations on patients and healthy individuals who have emigrated from the village of Karash and settled in villages near Sofia; in Strahinjic S, Stefanovic V (eds): Current Research in Endemic (Balkan) Nephropathy. Nis, University Press, 1983, pp 279–281.
- Jankovic S, Marinkovic J, Radovanovic Z: Survival of the upper urothelial cancer patients from the Balkan nephropathy endemic and non-endemic areas. Eur Urol 1988;15:59–61.
- Djokic M, Hadzi-Djokic J, Nikolic J, Dragicevic D, Radivojevic D: Comparison of upper urinary tract tumors in the region of Balkan nephropathy with those of other regions of Yugoslavia. Prog Urol 1999;9:61–68.
-
Petronic VJ, Bukurov NS, Djokic MR, Milenkovic DZ, Vuksanovic AM, Avramovic AD, Nale DP: Balkan endemic nephropathy and papillary transitional cell tumors of the renal pelvis and ureters. Kidney Int Suppl 1991;40:S77–S79.
External Resources
- Markovic N, Ignjatovic I, Cukuranovic R, Petrovic B, Kocic B, Stefanovic V: Decreasing incidence of urothelial cancer in a Balkan endemic nephropathy region in Serbia. A surgery based study from 1969–1998. Pathol Biol 2005;53:26-29.
- Ozsahin M, Zouhair A, Villa S, Storme G, Chauvet B, Taussky D, Gouders D, Ries G, Bontemps P, Coucke AP, Morimanoff OR: Prognostic factors in urothelial renal pelvis and ureter tumors: a multicenter rare cancer network study. Eur J Cancer 1999;35:738–743.
-
Petrovic B, Kocic B, Blagojevic L, Cukuranovic R: Bladder cancer and Balkan endemic nephropathy. J BUON 2001;6:315–318.
- Toncheva ID, Atanassova YS, Gergov DT, Todorovska GE, Roeva GI, Georgiev HT, Gremmels-Fink J, Zaharieva MB: Genetic changes in uroepithelial tumors of patients with Balkan endemic nephropathy. J Nephrol 2002;15:387–393.
- Toncheva D, Dimitrov T: Genetic predisposition to Balkan endemic nephropathy. Nephron 1996;72:564–569.
-
Toncheva DI, Gergov TD, Tzoneva MT, Bouchakliev ZP: Spontaneous and induced chromosome aberrations in Balkan endemic nephropathy. Kidney Int Suppl 1991;40:S97–S101.
- Elliott DS, Segura JW, Lightner D, Patterson DE, Blute ML: Is nephroureterectomy necessary in all cases of upper tract transitional cell carcinoma? Long-term results of conservative endourologic management of upper tract transitional cell carcinoma in individuals with a normal contralateral kidney. Urology 2001;58:174–178.
- Cukuranovic R, Petrovic B, Cukuranovic Z, Stefanovic V: Balkan endemic nephropathy: a decreasing incidence of the disease. Pathol Biol 2000;48:558–561.
- Dimitrov SP, Simeonov AV, Ganev SV, Karmaus JJW: Is the incidence of Balkan endemic nephropathy decreasing? Pathol Biol 2002;50:38–41.
Article / Publication Details
Received: June 24, 2005
Accepted: April 26, 2006
Published online: October 11, 2006
Issue release date: October 2006
Number of Print Pages: 5
Number of Figures: 1
Number of Tables: 5
ISSN: 0042-1138 (Print)
eISSN: 1423-0399 (Online)
For additional information: https://www.karger.com/UIN
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