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Original Research Article

Rethinking the Dementia Diagnoses in a Population-Based Study: What Is Alzheimer’s Disease and What Is Vascular Dementia?

A Study from the Kungsholmen Project
Agüero-Torres H.a-c · Kivipelto M.a-c · von Strauss E.a-c

Author affiliations

aAging Research Center (ARC), bDivision of Geriatric Epidemiology, Neurotec, Karolinska Institutet, and cStockholm Gerontology Research Center, Stockholm, Sweden

Related Articles for ""

Dement Geriatr Cogn Disord 2006;22:244–249

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Article / Publication Details

First-Page Preview
Abstract of Original Research Article

Received: March 18, 2006
Published online: August 30, 2006
Issue release date: August 2006

Number of Print Pages: 6
Number of Figures: 3
Number of Tables: 1

ISSN: 1420-8008 (Print)
eISSN: 1421-9824 (Online)

For additional information: https://www.karger.com/DEM

Abstract

Objective: To explore the hypothesis that older adults often are affected by more than one disease, making the differential diagnosis between Alzheimer’s disease (AD) and vascular dementia (VaD) difficult. Methods: Incident dementia cases (n = 308) from a population-based longitudinal study of people 75+ years were investigated. The DSM-III-R criteria were used for the clinical diagnosis of dementia. Data on vascular disorders (hypertension, cerebrovascular and ischemic heart diseases, heart failure, atrial fibrillation, diabetes) as well as type of onset/course of dementia were used retrospectively to reclassify dementias. Results: Only 47% of the AD cases were reclassified as pure AD without any vascular disorder. Among subjects with AD and with a vascular component, cerebrovascular disease was the most common (41%). Only 25% of VaD were reclassified as pure VaD. Further, 26% of the pure AD subjects developed a vascular disorder in the following 3 years. Conclusions: Both vascular and degenerative mechanisms may often contribute to the expression of dementia among the elderly. Most of the AD cases have vascular involvements, and pure dementia types in very old subjects constitute only a minority of dementia cases.

© 2006 S. Karger AG, Basel


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Article / Publication Details

First-Page Preview
Abstract of Original Research Article

Received: March 18, 2006
Published online: August 30, 2006
Issue release date: August 2006

Number of Print Pages: 6
Number of Figures: 3
Number of Tables: 1

ISSN: 1420-8008 (Print)
eISSN: 1421-9824 (Online)

For additional information: https://www.karger.com/DEM


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