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Original Research Article

Longitudinal Changes of Cerebral Glucose Metabolism in Semantic Dementia

Diehl-Schmid J.a · Grimmer T.a · Drzezga A.b · Bornschein S.a · Perneczky R.a · Förstl H.a · Schwaiger M.b · Kurz A.a

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Departments of aPsychiatry and Psychotherapy and bNuclear Medicine, Technische Universität München, Munich, Germany

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Dement Geriatr Cogn Disord 2006;22:346–351

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Article / Publication Details

First-Page Preview
Abstract of Original Research Article

Received: March 24, 2006
Published online: October 27, 2006
Issue release date: October 2006

Number of Print Pages: 6
Number of Figures: 2
Number of Tables: 1

ISSN: 1420-8008 (Print)
eISSN: 1421-9824 (Online)

For additional information: https://www.karger.com/DEM

Abstract

Background: Semantic dementia (SD). Objective: To identify the pattern of decline of cerebral glucose metabolism in SD using cerebral 18F-fluoro-2-desoxy-D-glucose positron emission tomography scanning (18F-FDG-PET). Methods: Eight patients with SD underwent 18F-FDG-PET at baseline and at re-examination in average 15 months later. Results: Compared with healthy control subjects, patients with SD showed a significant asymmetrical (left > right) hypometabolism of the temporal lobes, particularly of the anterior poles, at baseline. At follow-up, we observed a deterioration of cognitive abilities. However, in addition to the temporal lobes no other cortical or subcortical region showed a significant reduction of glucose metabolism except the anterior cingulate cortex (pcorr < 0.05). Conclusion: Subtle functional changes suffice to produce significant neuropsycho- logical deterioration.

© 2006 S. Karger AG, Basel


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Article / Publication Details

First-Page Preview
Abstract of Original Research Article

Received: March 24, 2006
Published online: October 27, 2006
Issue release date: October 2006

Number of Print Pages: 6
Number of Figures: 2
Number of Tables: 1

ISSN: 1420-8008 (Print)
eISSN: 1421-9824 (Online)

For additional information: https://www.karger.com/DEM


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