Effects of Salmeterol in Patients with Persistent Asthma Receiving Inhaled Corticosteroid plus TheophyllineInoue H.a · Komori M.a · Matsumoto T.a · Fukuyama S.a · Matsumura M.a · Nakano T.a · Tsuda M.a · Matsumoto K.a · Kanaya A.b · Moriwaki A.a · Aizawa H.c · Yoshida M.a · Nakanishi Y.a
aResearch Institute for Diseases of the Chest, Graduate School of Medical Sciences, Kyushu University, bDepartment of Hospital Pharmacy, Kyusyu University Hospital, and cFirst Department of Internal Medicine, Kurume University, Fukuoka, Japan
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Background: Patients with severe asthma require multiple therapies to improve lung function and reduce symptoms. The use of long-acting inhaled β2-agonists plus theophylline in addition to high doses of inhaled corticosteroids (ICSs) for the treatment of severe asthma has not been extensively studied. Objective: The purpose of this study was to investigate the efficacy and safety of salmeterol combined with high-dose ICSs plus theophylline in severe asthma. Methods: We undertook a randomized, placebo-controlled, crossover study to compare the effect of a single dose of inhaled salmeterol (50 µg) or a placebo in patients with severe asthma whose conditions were not being adequately controlled by therapies with high-dose ICSs plus oral theophylline with or without leukotriene receptor antagonists. Results: Twenty patients took part in the trial. Compared with the placebo, the inhalation of salmeterol significantly increased the FEV1. Even in the 9 patients treated with high-dose ICSs plus theophylline plus a leukotriene receptor antagonist, the FEV1 increased significantly more after salmeterol than after the placebo. Conclusion: Patients with severe asthma receiving high-dose ICSs plus theophylline may benefit from the addition of salmeterol.
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