Expression of T Cell [Receptor γδ Antigens in Human Brain TissueFrenzel K.-H.a · Müller N.a · Heidmann D.a · Hampel H.a · Kretzschmar H.A.c · Penning R.b · Ackenheil M.a
3 Psychiatric Hospital, and b Institute of Forensic Medicine, Ludwig Maximilian University, Munich and c Institute of Neuropathology, University of Göttingen, Germany
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The human γδ T cell receptor (TCR) is normally expressed on lymphoid tissue. Since expression of different molecules of the T cell system has been described for human brain cells, we examined the expression of CD4 and TCR γδ antigens with a panel of various anti-γδ TCR monoclonal antibodies (mAbs) and an anti-CD4 mAb using immunohistochemistry on different regions of frozen human postmortem tissue from five different brains. We could confirm the expression of CD4 antigens. γδ TCR expression on brain tissue was found in different regions of the brain by immunohistochemistry. Double staining with anti-γδ TCR and antineuronal enolase (NSE) mAbs showed that γδ TCR+ cells were not stained by anti-NSE, although they were sometimes located near neurons and showed dendritic forms; they are possibly tissue-resident γδ T cells, as described in the skin. Polymerase chain reaction analysis using a highly sensitive primer sequence against the constant-region δ sequence supports, combined with immunohistochemistry findings, the notion that the γδ TCR is expressed in human brain.
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