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Original Research Article

Free Access

Depression in Vascular Dementia Is Quantitatively and Qualitatively Different from Depression in Alzheimer’s Disease

Park J.H.a · Lee S.B.a · Lee T.J.a · Lee D.Y.d, e · Jhoo J.H.f · Youn J.C.c · Choo I.H.d · Choi E.A.a · Jeong J.W.a · Choe J.Y.a · Woo J.I.d, e · Kim K.W.a, b, e

Author affiliations

aDepartment of Neuropsychiatry and bStroke Center, Seoul National University Bundang Hospital, and cDepartment of Neuropsychiatry, Kyunggi Provincial Hospital for the Elderly, Gyeonggido, dDepartment of Neuropsychiatry, Seoul National University Hospital, and eSeoul National University College of Medicine, Seoul, and fDepartment of Neuropsychiatry, Kangwon University College of Medicine, Kangwondo, Korea

Corresponding Author

Ki Woong Kim, MD, PhD

Department of Neuropsychiatry, Seoul National University College of Medicine and

Seoul National University Bundang Hospital

300 Gumidong, Bundanggu, Seongnamsi, Gyeonggido 463-707 (Korea)

Tel. +82 31 787 7432, Fax +82 31 787 4058, E-Mail kwkimmd@snu.ac.kr

Related Articles for ""

Dement Geriatr Cogn Disord 2007;23:67–73

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Background/Aims: To compare the prevalence and characteristics of depression in vascular dementia (VaD) and Alzheimer’s disease (AD) after adjusting for dementia severity and gender. Methods: One hundred and eight pairs of VaD and AD patients matched for dementia severity and gender were assessed. Results: Major depressive disorder (MDD) was more prevalent in the VaD group than in the AD group (20.4% in VaD, 10.2% in AD, p = 0.04, Cochran-Mantel-Haenszel, CMH, test) regardless of the dementia severity and gender. The odds ratio for developing MDD in the VaD group versus the AD group was estimated to be 2.20 (95% confidence interval = 1.02–4.74). Neurovegetative symptoms such as ‘felt tired and weak all the time’ (30.6% in VaD, 13.9% in AD, p = 0.003, CMH test) and ‘changed weight without trying’ (16.7% in VaD, 6.5% in AD, p = 0.02, CMH test) were more prevalent in the VaD group than in the AD group. Conclusion: Depression in VaD was quantitatively and qualitatively different from that in AD regardless of the severity of dementia and gender; depression was more prevalent, severer and more retarded and vegetative in VaD than in AD.

© 2007 S. Karger AG, Basel

Article / Publication Details

First-Page Preview
Abstract of Original Research Article

Received: September 20, 2006
Published online: November 15, 2006
Issue release date: January 2007

Number of Print Pages: 7
Number of Figures: 1
Number of Tables: 3

ISSN: 1420-8008 (Print)
eISSN: 1421-9824 (Online)

For additional information: http://www.karger.com/DEM

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