Login to MyKarger

New to MyKarger? Click here to sign up.



Login with Facebook

Forgot your password?

Authors, Editors, Reviewers

For Manuscript Submission, Check or Review Login please go to Submission Websites List.

Submission Websites List

Institutional Login
(Shibboleth or Open Athens)

For the academic login, please select your country in the dropdown list. You will be redirected to verify your credentials.

Original Paper

The ‘Double Lung Point’: An Ultrasound Sign Diagnostic of Transient Tachypnea of the Newborn

Copetti R.a · Cattarossi L.b

Author affiliations

Departments of aEmergency and bPediatrics, S. Antonio Abate Hospital, Tolmezzo, Italy

Related Articles for ""

Neonatology 2007;91:203–209

Do you have an account?

Login Information





Contact Information










I have read the Karger Terms and Conditions and agree.



Login Information





Contact Information










I have read the Karger Terms and Conditions and agree.



To view the fulltext, please log in

To view the pdf, please log in

Buy

  • FullText & PDF
  • Unlimited re-access via MyKarger
  • Unrestricted printing, no saving restrictions for personal use
read more

CHF 38.00 *
EUR 35.00 *
USD 39.00 *

Select

KAB

Buy a Karger Article Bundle (KAB) and profit from a discount!

If you would like to redeem your KAB credit, please log in.


Save over 20% compared to the individual article price.
Learn more

Rent/Cloud

  • Rent for 48h to view
  • Buy Cloud Access for unlimited viewing via different devices
  • Synchronizing in the ReadCube Cloud
  • Printing and saving restrictions apply

Rental: USD 8.50
Cloud: USD 20.00


Select

Subscribe

  • Access to all articles of the subscribed year(s) guaranteed for 5 years
  • Unlimited re-access via Subscriber Login or MyKarger
  • Unrestricted printing, no saving restrictions for personal use
read more

Subcription rates


Select

* The final prices may differ from the prices shown due to specifics of VAT rules.

Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: February 27, 2006
Accepted: September 12, 2006
Published online: December 06, 2006
Issue release date: March 2007

Number of Print Pages: 7
Number of Figures: 7
Number of Tables: 2

ISSN: 1661-7800 (Print)
eISSN: 1661-7819 (Online)

For additional information: https://www.karger.com/NEO

Abstract

Background: Transient tachypnea of the newborn (TTN) is a mild form of neonatal respiratory distress which early in its course needs to be differentiated from other severe respiratory disorders. At present the diagnosis is based on radiological findings and clinical course. Lung sonography in TTN has not yet been assessed. Objectives: The aim of the study was to define the ultrasonographic appearance of TTN and evaluate its clinical relevance. Methods: Lung sonography was performed in 32 newborn infants with radiological and clinical signs of TTN within the first hour after birth and the findings were compared with those of 60 normal infants, 29 with respiratory distress syndrome, 6 with pneumonia, 5 with pulmonary hemorrhage and 5 with atelectasis. Results: In the infants with TTN, lung sonography showed a difference in lung echogenicity between the upper and lower lung areas. There were very compact comet-tail artifacts in the inferior fields while these were rare in the superior fields. We designated this finding the ‘double lung point’ and it was not observed in healthy infants, infants with respiratory distress syndrome, actelectasis, pneumothorax, pneumonia, or pulmonary hemorrhage. Sensitivity and specificity of the double lung point was 100% for the diagnosis of TTN. Conclusion: We found lung sonography reliable for the early diagnosis of TTN. We suggest that it should become the first approach for imaging of neonatal respiratory distress although further prospective studies with good blinding need to be performed.

© 2007 S. Karger AG, Basel


References

  1. Chernick V, Boat T (eds): Kendig’s Disorders of the Respiratory Tract in Children, ed 6. Oxford, Saunders, 1998, pp 337–338.
  2. O’Brodovich HM: Immature epithelial Na+ channel expression is one of the pathogenetic mechanisms leading to human neonatal respiratory distress syndrome. Proc Assoc Am Physicians 1996;108:345–355.
    External Resources
  3. O’Brodovich H: Epithelial ion transport in the fetal and perinatal lung. Am J Physiol Cell Physiol 1991;261:C555–C564.
  4. Greenough A, Lagercranz H: Catecholamine abnormalities in transient tachypnoea of the premature newborn. J Perinat Med 1992;20:223–226.
  5. Cheng JB, Goldfien A, Ballard PL, Roberts JM: Glucocorticoids increase pulmonary-adrenergic receptors in fetal rabbit. Endocrinology 1980;107:1646–1648.
  6. Parboosingh J, Lederis K, Singh N: Vasopressin concentration in cord blood. Correlation with methods of delivery and cord pH. Obstet Gynecol 1982;60:179–183.
  7. Milner AD, Saunders RA, Hopkin IE: Effects of delivery by caesarean section on lung mechanics and lung volume in the human neonate. Arch Dis Child 1978;53:545–548.
  8. Riskin A, Abend-Weinger M, Riskin-Mashiah S, Kugelman A, Bader D: Cesarean section, gestational age, and transient tachypnea of the newborn: timing is the key. Am J Perinatol 2005;22:377–382.
  9. Wesenberg RL, Graven SN, McCabe EB: Radiologic findings in wet lung disease. Radiology 1971;98:69–74.
  10. Lichtenstein DA, Menu Y: A bedside ultrasound sign ruling out pneumothorax in the critically ill. Lung sliding. Chest 1995;108:1345–1348.
  11. Lichtenstein D, Mezière G, Biderman P, Gepner A: The comet-tail artifact: an ultrasound sign ruling out pneumothorax. Intensive Care Med 1999;25:383–388.
  12. Lichtenstein DA, Lascols N, Mezière G, Gepner A: Ultrasound diagnosis of alveolar consolidation in the critically ill. Intensive Care Med 2004;30:276–281.
  13. Lichtenstein D, Mezière G, Biderman P, Gepner A, Barré O: The comet-tail artifact. An ultrasound sign of alveolar-interstitial syndrome. Am J Respir Crit Care Med 1997;156:1640–1646.
  14. Lichtenstein DA, Mezière G, Lascols N, Biderman P, Courret JP, Gepner A, Goldstein I, Tenoudji-Cohen M: Ultrasound diagnosis of occult pneumothorax. Crit Care Med 2005;33:1231–1238.
  15. Evans N: Current controversies in diagnosis and treatment of patent ductus arteriosus in preterm infants. Adv Neonatal Care 2003;3:168–177.
  16. Lichtenstein D, Lascols N, Prin S, Mezière G: The lung pulse: an early ultrasound sign of complete atelectasis. Intensive Care Med 2003;29:2187–2192.
  17. Miller MJ, Fanaroff AA, Martin RJ: Respiratory disorders in preterm and term infants; in Fanaroff AA, Martin RJ (eds): Neonatal-Perinatal Medicine: Diseases of the Fetus and Infant, ed 6. St Louis, Mosby, 1997, pp 1040–1065.
  18. Avni EF, Braude P, Pardue A, Matos C: Hyaline membrane disease in the newborn: diagnosis by ultrasound. Pediatr Radiol 1990;20:143–146.
  19. Avni EF, Cassart M, de Maertelaer V, Rypens F, Vermeylen D, Gevenois PA: Sonographic prediction of chronic lung disease in the premature undergoing mechanical ventilation. Pediatr Radiol 1996;26:463–469.
  20. Pieper CH, Smith J, Brand EJ: The value of ultrasound examination of the lungs in predicting bronchopulmonary dysplasia. Pediatr Radiol 2004;34:227–231.
  21. Staub NC: Pulmonary edema. Physiol Rev 1974;54:678–811.
  22. O’Brodovich H: Pulmonary edema fluid movement within the lung. Am J Physiol Lung Cell Mol Physiol 2001;281:L1324–L1326.
  23. Miserocchi G: The interstitial and microvascular unit of the lung: from the neonate to the adult; in Weir EK, Reeves JT, Reeves Sl (eds): Pulmonary Edema. Oxford, Futura (Blackwell), 1998.
  24. Lichtenstein D, Goldstein I, Mourgeon E, Cluzel P, Grenier P, Rouby JJ: Comparative diagnostic performances of auscultation, chest radiography, and lung ultrasonography in acute respiratory distress syndrome. Anesthesiology 2004;100:9–15.

Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: February 27, 2006
Accepted: September 12, 2006
Published online: December 06, 2006
Issue release date: March 2007

Number of Print Pages: 7
Number of Figures: 7
Number of Tables: 2

ISSN: 1661-7800 (Print)
eISSN: 1661-7819 (Online)

For additional information: https://www.karger.com/NEO


Copyright / Drug Dosage / Disclaimer

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.