Cerebrovascular Diseases
Original Paper
Risk Factor, Pattern, Etiology and Outcome in Ischemic Stroke Patients with Cancer: A Nested Case-Control StudyZhang Y.Y.a, e · Cordato D.b · Shen Q.a · Sheng A.Z.a · Hung W.T.d · Chan D.K.Y.a, cDepartments of aAged Care and Rehabilitation and bNeurology, Bankstown-Lidcombe Hospital, and cUniversity of New South Wales, Sydney, and dBreast Screen NSW, State Coordination Unit, Parramatta, Australia; eDepartment of Neurology, Shanghai Yueyang Hospital of Chinese and Western Medicine, Shanghai, China
Keywords: Ischemic strokeCancer, risk factor |
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Article / Publication Details
Received: February 13, 2006
Accepted: July 20, 2006
Published online: December 01, 2006
Issue release date: February 2007
Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 4
ISSN: 1015-9770 (Print)
eISSN: 1421-9786 (Online)
For additional information: https://www.karger.com/CED
Abstract
Background: Coagulation disorders are seen in cancer patients, but it is not clear whether cancer predisposes stroke patients to unique characteristics. The aim of the study was to investigate risk factors, pattern,etiology and outcome in stroke patients with cancer. Methods: A retrospective review of all ischemic stroke (IS) patients with cancer (n = 56) admitted to Bankstown-Lidcombe Hospital, Sydney, Australia, between January 1999 and December 2004 was conducted and comparison made to age- and gender-matched noncancer IS patients admitted to the same hospital during the same period. Results: Vascular risk factors and stroke pattern were comparable in cancer and noncancer groups. Poststroke thrombotic episodes (myocardial infarction, deep vein thrombosis or pulmonary emboli) were more common in the cancer group than in the noncancer group (11 vs. 0%, p = 0.031). Depression was also more common in the cancer group than in the noncancer group (14 vs. 2%, p = 0.039). There was a tendency for more patients in the cancer group to die in hospital (30 vs. 14%, p = 0.078). Conclusions: Coagulation disorders were more likely to be seen in stroke cancer patients, and patients with cancer tended to have a higher in-hospital poststroke mortality. Larger sample size studies may identify further differences in the characteristics of stroke patients with cancer.
© 2007 S. Karger AG, Basel
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References
- Cestari DM, Weine DM, Panageas KS, Segal AZ, De Angelis LM: Stroke in patients with cancer: incidence and etiology. Neurology 2004;62:2025–2030.
- Amico L, Caplan LR, Thomas C: Cerebrovascular complications of mucinous cancers. Neurology 1989;39:522–526.
- Packer RJ, Rorke LB, Lange BJ, Siegel KR, Evans AE: Cerebrovascular accidents in children with cancer. Pediatrics 1985;76:194–201.
- O’Neill BP, Dinapoli RP, Okazaki H: Cerebral infarction as a result of tumor emboli. Cancer 1987;60:90–95.
- Lefkovitz NW, Roessmann U, Kori SH: Major cerebral infarction from tumor embolus. Stroke 1986;17:555–557.
- Rogers LR: Cerebrovascular complications in cancer patients. Neurol Clin 2003;21:167–192.
- Graus F, Rogers LR, Posner JB: Cerebrovascular complications in patients with cancer. Medicine 1985;64:16–35.
- Nilsson G, Holmberg L, Garmo H, Terent A, Blomqvist C: Increased incidence of stroke in women with breast cancer. Eur J Cancer 2005;41:423–429.
- Sudlow CL, Warlow CP: Comparable studies of the incidence of stroke and its pathological types: results from an international collaboration. International Stroke Incidence. Stroke 1997;28:491–499.
- Kitamura A, Iso H, Iida M, Naito Y, Sato S, Jacobs DR, Nakamura M, Shimamoto T, Komachi Y: Trends in the incidence of coronary heart disease and stroke and the prevalence of cardiovascular risk factors among Japanese men from 1963 to 1994. Am J Med 2002;112:104–109.
- Intiso D, Stampatore P, Zarrelli MM, Guerra GL, Arpaia G, Simone P, Tonali P, Beghi E: Incidence of first-ever ischemic and hemorrhagic stroke in a well-defined community of southern Italy, 1993–1995. Eur J Neurol2003;10:559–565.
- Graus F, Rogers LR, Posner JB: Cerebrovascular complications in patients with cancer. Medicine 1985;64:16–35.
- Chaturvedi S, Ansell J, Recht L: Should cerebral ischemic events in cancer patients be considered a manifestation of hypercoagulability? Stroke 1994;25:1215–1218.
-
The International Statistical Classification of Diseases and Related Health Problems, rev 10, Australian modification (ICD-10-AM). Sydney, National Centre for Classification in Health, 2004.
- Lai SM, Duncan PW: Stroke recovery profile and the modified Rankin assessment. Neuroepidemiology 2001;20:26–30.
- Adams HP Jr, Bendixen BH, Kappelle LJ: Classification of subtype of acute ischemic stroke: definitions for use in a multicenter clinical trial. TOAST Trial of Org 10172 in Acute Stroke Treatment. Stroke 1993;24:35–41.
-
Selvin S: Modern Applied Biostatistical Methods Using S-Plus. Oxford, Oxford University Press, 1998, pp 328–330.
- Maxwell AE: Comparing the classification of subjects by two independent judges. Br J Psychiatry 1970;116:651–655.
- Arakawa M, Miyake Y, Taira K: Hypertension and stroke in centenarians, Okinawa, Japan. Cerebrovasc Dis 2005;20:233–238.
- Melnik TA, Hosler AS, Sekhobo JP, Duffy TP, Tierney EF, Engelgau MM, Geiss LS: Diabetes prevalence among Puerto Rican adults in New York City, NY, 2000. Am J Public Health 2004;94:434–437.
- Lloyd-Jones DM, Wang TJ, Leip EP, Larson MG, Levy D, Vasan RS, D’Agostino RB, Massaro JM, Beiser A, Wolf PA, Benjamin EJ: Lifetime risk for development of atrial fibrillation: the Framingham Heart Study. Circulation 2004;110:1042–1046.
- Shen Q, Cordato DJ, Chan DK, Kokkinos J: Comparison of stroke risk factors and outcomes in patients with English-speaking background versus non-English-speaking background. Neuroepidemiology 2005;24:79–86.
- Joffee II, Jacobs LE, Owen AN, Ioli A, Kotler MN: Noninfective valvular masses: review of the literature with emphasis on imaging techniques and management. Am Heart J 1996;131:1175–1183.
-
Wojtukiewicz MZ, Sierko E, Zacharski LR, Zimnoch L, Kudryk B, Kisiel W: Tissue factor-dependent coagulation activation and impaired fibrinolysis in situ in gastric cancer. Semin Thromb Hemost 2003;329:291–300.
-
Kohli M, Kaushal V, Mehta P: Role of coagulation and fibrinolytic system in prostate cancer. Semin Thromb Hemost 2003;329:301–308.
- Caine GJ, Stonelake PS, Lip GY, Kehoe ST: The hypercoagulable state of malignancy: pathogenesis and current debate. Neoplasia 2002;4:465–473.
Article / Publication Details
Received: February 13, 2006
Accepted: July 20, 2006
Published online: December 01, 2006
Issue release date: February 2007
Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 4
ISSN: 1015-9770 (Print)
eISSN: 1421-9786 (Online)
For additional information: https://www.karger.com/CED
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