Pathophysiology of Haemostasis and Thrombosis
Original Paper
Relationship between Hemostatic Factors and the Platelet Index in Patients with Ischemic Heart DiseaseIhara A.a, c, g · Kawamoto T.b · Matsumoto K.b · Shouno S.d · Morimoto T.e · Noma Y.fDepartments of aHematology and bCardiology, and Institutes of cClinical Research and dClinical Laboratory, National Hospital Organization Kure Medical Center, eMorimoto Medical Clinic, and fNoma Clinic, Kure, and gDepartment of Internal Medicine, National Hospital Organization Kamo Psychiatry Medical Center, Hiroshima, Japan
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Article / Publication Details
Received: February 20, 2006
Accepted: July 26, 2006
Published online: January 26, 2007
Issue release date: January 2007
Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 1
ISSN: 1424-8832 (Print)
eISSN: 1424-8840 (Online)
For additional information: https://www.karger.com/PHT
Abstract
To understand the heterogeneity of platelets, we investigated the correlation between hemostatic factors and the platelet index [platelet count, mean platelet volume (MPV), platelet-large cell ratio (P-LCR) and platelet distribution width (PDW)] in patients with ischemic heart disease (IHD). Ninety-seven patients with IHD and 120 aged controls (AC) were enrolled in the study. D-dimer, thrombin-antithrombin III complex (TAT), von Willebrand factor antigen (VWF:Ag) and platelet indexes were measured in the peripheral venous blood. The D-dimer and TAT levels in the patients were significantly elevated compared to the AC. VWF:Ag was also elevated, but not significantly so. However, no differences were observed in the platelet index between the patients and the AC. In the patients, the level of VWF:Ag was significantly inversely correlated with the platelet count, but such correlations were not observed in the D-dimer and TAT. TAT was significantly positively correlated with MPV, P-LCR and PDW. VWF:Ag was also correlated, though not significantly, with MPV, P-LCR and PDW. The D-dimer was not correlated with the platelet index. In the AC, the platelet count was inversely correlated with VWF:Ag, but not significantly so. VWF:Ag showed significant positive correlations with MPV, P-LCR and PDW. However, the D-dimer and TAT were not correlated with the platelet index in AC. These findings suggest that VWF:Ag and TAT seem to be profoundly related to platelet volume.
© 2006 S. Karger AG, Basel
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References
- Pizzulli L, Yang A, Martin JF, Luderitz B: Changes in platelet size and count in unstable angina compared to stable angina or non-cardiac chest pain. Eur Heart J 1998;19:80–84.
- Erne P, Wardle J, Sanders K, Lewis SM, Maseri A: Mean platelet volume and size distribution and their sensitivity to agonists in patients with coronary artery disease and congestive heart failure. Thromb Haemost 1988;59:259–263.
- Endler G, Klimesch A, Sunder-Plassmann H, Schillinger M, Exner M, Mannhalter C, Jordanova N, Christ G, Thalhammer R, Huber K, Sunder-Plassmann R: Mean platelet volume is an independent risk factor for myocardial infarction but not for coronary artery disease. Br J Haematol 2002;117:399–404.
-
Ihara A, Furubayashi T, Kobayashi Y, Kawamoto T, Yoshino K, Ishikawa K, Fujimura K, Kuramoto A: Clinical significance of thrombosis-related markers in ischemic heart disease: correlation with angiographic morphology. Jpn J Thromb Hemost 1993;4:23–29.
- Heper G, Bayraktaroglu M: The importance of von Willebrand factor level and heart rate changes in acute coronary syndromes: a comparison with chronic ischemic conditions. Angiology 2003;54:287–299.
-
Lowe GDO, Rumley A, Sweetnam PM, Yarnell JW, Rumley J: Fibrin D-dimer, markers of coagulation activation and the risk of major ischaemic heart disease in the caerphilly study. Thromb Haemost 2001;85:822–827.
- Oldgren J, Linder R, Grip L, Siegbahn A, Wallentin L: Coagulation activity and clinical outcome in unstable coronary artery disease. Arterioscler Thromb Vasc Biol 2001;21:1059–1064.
- Ihara A, Matsumoto K, Kawamoto T, Shouno S, Katayama A, Yoshitatsu M, Izutani H: Evaluation of platelet indexes in patients with aortic aneurysm. Pathophysiol Haemost Thromb 2005;34:269–273.
-
Ihara A, Shiiki T, Sakaguti R, Kobayashi Y, Tokioka M, Imaizumi M, Yutani T, Tsushima M: Study of von Willebrand factor and antithrombin III in patients with atherosclerosis. Iryo 1988;42:168–172.
-
Ihara A, Morimoto T, Kobayashi Y, Noma Y, Maehama S, Takata N, Kusumi S, Fujimura K, Kuramoto A: Study of von Willebrand factor and protein C in patients with myocardial infarction. Blood Vessel 1988;19:412–414.
- Heper G, Bayraktaroglu M: The importance of von Willebrand factor level and heart rate changes in acute coronary syndromes: a comparison with chronic ischemic conditions. Angiology 2003;54:287–299.
-
Morange PE, Simon C, Alessi MC, Luc G, Arveiler D, Ferrieres J, Amouyel P, Evans A, Ducimetiere P, Juhan-Vague I, PRIME Study Group: Endothelial cell markers and the risk of coronary heart disease: the Prospective Epidemiological Study of Myocardial Infarction (PRIME) study. Circulation 2004;23:1343–1348.
External Resources
- Mathur A, Robinson MS, Cotton J, Martin JF, Erusalimsky JD: Platelet reactivity in acute coronary syndromes: evidence for differences in platelet behavior between unstable angina and myocardial infarction. Thromb Haemost 2001;85:989–994.
- Brodin E, Børvik T, Sandset PM, Bønaa KH, Nordøyl A, Hansen JB: Coagulation activation in young survivors of myocardial infarction (Ml) – a population-based case-control study. Thromb Haemost 2004;92:178– 184.
- Bayes-Genis A, Mateo J, Santalo M, Oliver A, Guindo J, Badimon L, Martinez-Rubio A, Fontcuberta J, Schwartz RS, Byes de Luna A: D-Dimer is an early diagnostic marker of coronary ischemia in patients with chest pain. Am Heart J 2000;140:379–384.
Article / Publication Details
Received: February 20, 2006
Accepted: July 26, 2006
Published online: January 26, 2007
Issue release date: January 2007
Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 1
ISSN: 1424-8832 (Print)
eISSN: 1424-8840 (Online)
For additional information: https://www.karger.com/PHT
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