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Short Report

Mapping platypus SOX genes; autosomal location of SOX9 excludes it from sex determining role

Wallis M.C.a · Delbridge M.L.a · Pask A.J.b · Alsop A.E.a · Grützner F.c · O’Brien P.C.M.d · Rens W.d · Ferguson-Smith M.A.d · Graves J.A.M.a

Author affiliations

aComparative Genomics Group, Research School of Biological Sciences, The Australian National University, Canberra; bDepartment of Zoology, The University of Melbourne, Melbourne cSchool of Molecular and Biomedical Science, The University of Adelaide, Adelaide (Australia) dCambridge Resource Centre for Comparative Genomics, Department of Veterinary Medicine, University of Cambridge, Cambridge (UK)

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Cytogenet Genome Res 116:232–234 (2007)

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Article / Publication Details

First-Page Preview
Abstract of Short Report

Published online: February 23, 2007
Issue release date: February 2007

Number of Print Pages: 3
Number of Figures: 2
Number of Tables: 0

ISSN: 1424-8581 (Print)
eISSN: 1424-859X (Online)

For additional information: https://www.karger.com/CGR

Abstract

In the absence of an SRY orthologue the platypus sex determining gene is unknown, so genes in the human testis determining pathway are of particular interest as candidates. SOX9 is an attractive choice because SOX9 deletions cause male-to-female sex reversal in humans and mice, and SOX9 duplications cause female-to-male sex reversal. We have localized platypus SOX9, as well as the related SOX10, to platypus chromosomes 15 and 10, respectively, the first assignments to these platypus chromosomes, and the first comparative mapping markers from human chromosomes 17 and 22. The autosomal localization of platypus SOX9 in this study contradicts the hypothesis that SOX9 acts as the sex determining switch in platypus.

© 2007 S. Karger AG, Basel


References

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Article / Publication Details

First-Page Preview
Abstract of Short Report

Published online: February 23, 2007
Issue release date: February 2007

Number of Print Pages: 3
Number of Figures: 2
Number of Tables: 0

ISSN: 1424-8581 (Print)
eISSN: 1424-859X (Online)

For additional information: https://www.karger.com/CGR


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