Rice: Another Potential Cause of Food Allergy in Patients Sensitized to Lipid Transfer ProteinAsero R.a · Amato S.b · Alfieri B.c · Folloni S.c · Mistrello G.b
aAmbulatorio di Allergologia, Clinica San Carlo, Paderno Dugnano, bLofarma SpA, Milan, and cDepartment of Biochemistry and Molecular Biology, University of Parma, Parma, Italy
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Article / Publication Details
Recent studies show that the lipid transfer protein (LTP), the major Rosaceae allergen in patients not sensitized to birch pollen, is a largely cross-reacting allergen. Moreover, it is a potentially hazardous allergen due to its stability upon thermal treatment and pepsin digestion. The present study reports 3 cases of rice-induced anaphylaxis in LTP-allergic patients. In vitro inhibition studies, carried out using LTP purified from both rice and apple as well as whole peach extract, show that LTP was the relevant allergen in these patients and demonstrate the cross-reactivity between rice LTP and peach/apple LTP.
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- Breiteneder H, Ebner C: Molecular and biochemical classification of plant-derived food allergens. J Allergy Clin Immunol 2000;106:27–36.
- Pastorello EA, Ortolani C, Farioli L, Pravettoni V, Ispano M, et al: Allergenic cross-reactivity among peach, apricot, plum, cherry in patients with oral allergy syndrome: an in vivo and in vitro study. J Allergy Clin Immunol 1994;94:699–707.
- Sanchez-Monge R, Lombardero M, Garcia-Selles FJ, Barber D, Salcedo G: Lipid transfer proteins are relevant allergens in fruit allergy. J Allergy Clin Immunol 1999;103:514–519.
- Diaz-Perales A, Lombardero M, Sanchez-Monge R, Garcia-Selles FJ, Pernas M, Fernandez-Rivas M, Barber D, Salcedo G: Lipid transfer proteins as potential plant panallergens: cross-reactivity among proteins of Artemisia pollen, Castanea nut, and Rosaceae fruits, with different IgE binding capacities. Clin Exp Allergy 2000;30:1403–1410.
- Asero R, Mistrello G, Roncarolo D, de Vries SC, et al: Lipid transfer protein: a pan-allergen in plant-derived foods that is highly resistant to pepsin digestion. Int Arch Allergy Immunol 2000;122:20–32.
- Asero R, Mistrello G, Roncarolo D, Amato S, Calderoni G, Barocci F, van Ree R: Immunological cross-reactivity between lipid transfer proteins from botanically unrelated plant-derived foods: a clinical study. Allergy 2002;57:900–906.
- Asero R, Mistrello G, Roncarolo D, Amato S: Relationship between peach lipid transfer protein IgE levels and hypersensitivity to non-Rosaceae vegetable foods in patients allergic to lipid transfer protein. Ann Allergy Asthma Immunol 2004;92:268–272.
- Brenna O, Pompei C, Ortolani C, Pravettoni V, Farioli L, Pastorello EA: Technological processes to decrease the allergenicity of peach juice and nectar. J Agric Food Chem 2000;48:493–497.
- Asero R, Mistrello G, Roncarolo D, Amato S, Falagiani S: Analysis of the heat stability of lipid transfer protein from apple. J Allergy Clin Immunol 2003;112:1009–1011.
- Pastorello EA, Pompei C, Pravettoni V, Farioli L, Calamari AM, Scibilia J, Robino AM, Conti A, et al: Lipid transfer protein is the major maize allergen maintaining IgE-binding activity after cooking at 100 degrees C, as demonstrated in anaphylactic patients and patients with positive double-blind, placebo-controlled food challenge results. J Allergy Clin Immunol 2003;112:775–783.
- Scheurer S, Lauer I, Foetisch K, Moncin MS, Retzek M, Hartz C, et al: Strong allergenicity of Pru av 3, the lipid transfer protein from cherry, is related to high stability against thermal processing and digestion. J Allergy Clin Immunol 2004;114:900–907.
- Fernandez-Rivas M, van Ree R, Cuevas M: Allergy to Rosaceae fruits without related pollinosis. J Allergy Clin Immunol 1997;100:728–733.
Lleonart R, Cisterò A, Carreira J, Batista A, Moscoso del Prado J: Food allergy: identification of the major IgE-binding component of the peach (Prunus persica). Ann Allergy 1992;69:120–130.
- Escribano MM, Munoz FJ, Velazquez E, Gonzalez J, Conde J: Anaphylactic reaction caused by cherry ingestion. Allergy 1996;51:756–757.
- Asero R: Detection and clinical characterization of patients with oral allergy syndrome caused by stable allergens in Rosaceae and nuts. Ann Allergy Asthma Immunol 1999;83:377–383.
- Schocker F, Luttkopf D, Scheurer S, Petersen A, Cistero-Bahima A, Enrique E, San Miguel-Moncin M, Akkerdaas J, van Ree R, Vieths S, Becker WM: Recombinant lipid transfer protein Cor a 8 from hazelnut: a new tool for in vitro diagnosis of potentially severe hazelnut allergy. J Allergy Clin Immunol 2004;113:141–147.
- Pastorello EA, Farioli L, Pravettoni V, Robino AM, Scibilia J, Fortunato D, Conti A, Borgonovo L, Bengtsson A, Ortolani C: Lipid transfer protein and vicilin are important walnut allergens in patients not allergic to pollen. J Allergy Clin Immunol 2004;114:908–914.
- Pastorello EA, Farioli L, Pravettoni V, Ispano M, et al: The maize major allergen, which is responsible for food-induced allergic reactions, is a lipid transfer protein. J Allergy Clin Immunol 2000;106:744–751.
- Curioni A, Santucci B, Cristaudo A, Canistraci C, Pietravalle M, Limonato B, et al: Urticaria from beer: an immediate hypersensitivity reaction due to a 10-kDa protein derived from barley. Clin Exp Allergy 1999;29:407–413.
- Asero R, Mistrello G, Roncarolo D, Amato S, van Ree R: A case of allergy to beer showing cross-reactivity between lipid transfer proteins. Ann Allergy Asthma Immunol 2001;87:65–67.
- Pastorello EA, Farioli L, Pravettoni V, Ortolani C, Fortunato D, Giuffrida MG, et al: Identification of grape and wine allergens as an endochitinase 4, a lipid-transfer protein and a thaumatin. J Allergy Clin Immunol 2003;111:350–359.
- Navarro AM, Orta JC, Sanchez MC, Delgado J, Barber D, Lombardero M: Primary sensitization to Morus alba. Allergy 1997;52:1144–1145.
- Yu YG, Chung CH, Fowler A, Suh SW: Amino acid sequence of a probable amylase/protease inhibitor from rice seeds. Arch Biochem Biophys 1988;265:466–475.
- Bradford MM: A rapid and sensitive method for the quantification of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976;72:248–254.
- Asero R, Mistrello G, Roncarolo D, Casarini M, Falagiani P: Allergy to nonspecific lipid transfer proteins in Rosaceae: a comparative study of different in vivo diagnostic methods. Ann Allergy Asthma Immunol 2001;87:68–71.
- Towbin H, Staehelin T, Gordon J: Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications. Proc Natl Acad Sci USA 1979;76:4350–4354.
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