European Neurology

Original Paper

Selective Decline in Information Processing in Subgroups of Multiple Sclerosis: An 8-Year Longitudinal Study

Bergendal G.a · Fredrikson S.a · Almkvist O.b, c

Author affiliations

Divisions of aNeurology, Department of Clinical Neuroscience, and bClinical Geriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institute, and cDepartment of Psychology, Stockholm University, Stockholm, Sweden

Keywords: CognitionInformation processesMultiple sclerosis

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Eur Neurol 2007;57:193–202
https://doi.org/10.1159/000099158

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: June 14, 2006
Accepted: November 01, 2006
Published online: January 31, 2007
Issue release date: May 2007

Number of Print Pages: 10
Number of Figures: 3
Number of Tables: 2

ISSN: 0014-3022 (Print)
eISSN: 1421-9913 (Online)

For additional information: https://www.karger.com/ENE

Abstract

Multiple sclerosis (MS) is an inflammatory and degenerative disease of the central nervous system (CNS) that causes white matter and cortical lesions over many years. The CNS is selectively affected by the disease with a great variety of symptoms between patients. In this study, we describe the impact on various aspects of cognition over an 8-year follow-up period in 31 consecutive MS patients subgrouped as relapsing remitting (RR) MS, secondary progressive (SP) MS, and primary progressive (PP) MS. Results showed a differential pattern of cognitive decline already at baseline in speed of information processing. During the follow-up, a pronounced decline occurred in speed of information processing, finger-motor speed, copying geometrical designs, episodic memory, and visuospatial short-term memory. A striking difference was observed between a marked decline in visual reaction time, whereas no significant change was seen in auditory reaction time. In contrast, there was no time-related decline in verbal abilities. However, an initial marked cognitive impairment predicted further cognitive decline over the 8-year follow-up. Information-processing tests were found to be an especially strong predictor of long-term cognitive decline. In addition, high EDSS score at follow-up was associated with decline in information processes. Results also showed that SP-MS patients deteriorated significantly more than the other two groups, particularly in visual compared to auditory information processing. To conclude, cognitive decline appeared particularly in SP-MS patients and in visual information processing.

© 2007 S. Karger AG, Basel



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References

  1. Peyser JM, Rao SM, La Rocca NG, Kaplan E: Guidelines for neuropsychological research in multiple sclerosis. Arch Neurol 1990;47:94–97.
    External Resources
  2. Rao SM: Assessment of cognitive impairment in multiple sclerosis. MS Management 1995;2:31–35.
  3. Foong J, Ron M: Cognitive impairment and neuropsychological assessment in multiple sclerosis. Int MS J 1999;7:31–33.
  4. Nocentini U, Pasqualetti P, Bonavita S, Buccafusca M, De Caro MF, Farina D, Girlanda P, Le Pira F, Lugaresi A, Quattrone A, Reggio A, Salemi G, Savetteri G, Tedeschi G, Trojano M, Valentino P, Caltagirone C: Cognitive dysfunction in patients with relapsing-remitting multiple sclerosis. Mult Scler 2006;12:77–87.
    External Resources
  5. Rao SM, Leo GJ, Bernardin L, Unverzagt F: Cognitive dysfunction in multiple sclerosis. Frequency, patterns and prediction. Neurology 1991;41:685–691.
    External Resources
  6. Lensch E, Matzke M, Petereit HF, Scherer P, Schramm S, Calabrese P: Identification and management of cognitive disorders in multiple sclerosis A – consensus approach. J Neurol 2006;253(suppl 1):I29–I31.
    External Resources
  7. Calabrese P: Neuropsychology of multiple sclerosis – an overview. J Neurol 2006;253 (suppl 1):I10–I15.
    External Resources
  8. Archibald CJ, Fisk JD: Information processing efficiency in patients with multiple sclerosis. J Clin Exp Neuropsychol 2000;22:686–701.
    External Resources
  9. Piras MR, Magnano I, Canu EDG, Paulus KS, Satta WM, Soddu A, Conti M, Achene A, Solinas G, Aiello I: Longitudinal study of cognitive dysfunction in multiple sclerosis: neuropsychological, neuroradiological, and neurophysiological findings. J Neurol Neurosurg Psychiatry2003;74:878–885.
    External Resources
  10. Grafman J, Rao SM, Litvan I: Disorders of memory; in Rao SM (ed): Neurobehavioral Aspects of Multiple Sclerosis. New York, Oxford University Press, 1990, pp 102–117.
  11. Bobholz JA, Rao SM: Cognitive dysfunction in multiple sclerosis: a review of recent developments. Curr Opin Neurol 2003;16:283–288.
    External Resources
  12. Feinstein A: The Clinical Neuropsychiatry of Multiple Sclerosis. Cambridge, Cambridge University Press, 1999.
  13. Friend KB, Rabin BM, Groninger L, Deluty RH, Bever C, Grattan L: Language functions in patients with multiple sclerosis. Clin Neuropsychol 1999;13:78–94.
    External Resources
  14. Caine ED, Bamford KA, Schiffer RB, Shoulson I, Levy S: A controlled neuropsychological comparison of Huntington’s disease and multiple sclerosis. Arch Neurol 1986;43:249–254.
    External Resources
  15. Achiron A, Polliack M, Rao SM, Barak Y, Lavie M, Appelboim N, Harel Y: Cognitive patterns and progression in multiple sclerosis: construction and validation of percentile curves. J Neurol Neurosurg Psychiatry 2005;76:744–749.
    External Resources
  16. Mendozzi L, Pugnetti L, Saccani M, Motta A: Frontal lobe dysfunction in multiple sclerosis as assessed by means of Lurian tasks: effects of age of onset. J Neurol Sci 1993;115(suppl):S42–S50.
    External Resources
  17. Feinstein A: Neuropsychological dysfunction in multiple sclerosis. Int MS J 1995;2:61–67.
  18. Ivnik RJ: Neuropsychological stability in multiple sclerosis. J Consult Clin Psychol 1978;46:913–923.
    External Resources
  19. Zakzanis KK: Distinct neurocognitive profiles in multiple sclerosis subtypes. Arch Clin Neuropsychol 2000;15:115–136.
    External Resources
  20. Jennekens-Schinkel A, Laboyrie PM, Lanser JBK, van der Velde EA: Cognition in patients with multiple sclerosis after four years. J Neurol Sci 1990;99:229–247.
    External Resources
  21. Amato MP, Ponziani G, Pracucci G, Bracco L, Siracusa G, Amaducci L: Cognitive impairment in early-onset multiple sclerosis. Arch Neurol 1995;52:168–172.
    External Resources
  22. Hohol MJ, Guttman CR, Orav J, Mackin GA, Kikinis R, Khoury SJ, Jolesz FA, Weiner HL: Serial neuropsychological assessment and magnetic resonance imaging analysis in multiple sclerosis. Arch Neurol 1997;54:1018–1025.
    External Resources
  23. Kujala P, Portin R, Ruutiainen J: The progress of cognitive decline in multiple sclerosis: a controlled 3-year follow-up. Brain 1997;120:289–297.
    External Resources
  24. Olivieri RL, Cittadella R, Sibilia G, Manna I, Valentino P, Gambardella A, Aguglia U, Zappia M, Romeo N, Andreoli V, Bono F, Caracciolo M, Qattrone A: APOE and risk of cognitive impairment in multiple sclerosis. Acta Neurol Scand 1999;100:290–295.
    External Resources
  25. Savettieri G, Messina D, Andreoli V, Bonavita S, Caltagirone C, Cittadella R, Farina D, Fazio MC, Girlanda P, Le Pira F, Liguori M, Lugaresi A, Nocentini U, Reggio A, Salemi G, Tedeschi G, Trojano M, Valentino P, Quattrone A: Gender-related effect of clinical and genetic variables on the cognitive impairment in multiple sclerosis. J Neurol 2004;251:1208–1214.
    External Resources
  26. Pinholt M, Frederiksen JL, Andersen PS, Christiansen M: Apo E in multiple sclerosis and optic neuritis: the apo E-ε4 allele is associated with progression of multiple sclerosis. Mult Scler 2005;11:511–515.
    External Resources
  27. Amato MP, Ponziani G, Siracusa G, Sorbi S: Cognitive dysfunction in early-onset multiple sclerosis: a reappraisal after 10 years. Arch Neurol 2001;58:1602–1606.
    External Resources
  28. Beatty WW, Goodkin DE, Hertsgaard D, Monson N: Clinical and demographic predictors of cognitive performance in MS. Do diagnostic type, disease duration and disability matter? Arch Neurol 1990;47:305–308.
    External Resources
  29. Friend KB, Grattan L: Use of the North American Adult Reading Test to estimate premorbid intellectual function in patients with multiple sclerosis. J Clin Exp Neuropsychol 1998;20:846–851.
    External Resources
  30. Poser CM, Paty DW, Scheinberg I, McDonald WI, Davis DA, Ebers GC, Johnson KP, Sibley WA, Silberberg DH, Tourtellotte WW: New diagnostic criteria for multiple sclerosis: guidelines for research protocols. Ann Neurol 1983;13:227–231.
    External Resources
  31. Lublin FD, Reingold SC: Defining the clinical course of multiple sclerosis: results of an international survey. Neurology 1996;46:907–911.
    External Resources
  32. Kurtzke JF: Rating neurologic impairment in multiple sclerosis: an expanded disability scale. Neurology 1983;33:1444–1452.
    External Resources
  33. Wechsler D: Wechsler Adult Intelligence Scale – Revised: Manual. San Antonio/Tx, Psychological Corporation, 1981.
  34. Bartfai A, Nyman H, Stegman B: Wechsler Adult Intelligence Scale Revised: WAIS-R Manual. Stockholm, Psykologiförlaget, 1994.
  35. Lezak M: Neuropsychological Assessment. New York, Oxford University Press, 1995.
  36. Levander S, Elithorn A: Department of Psychiatry and Behavioural Medicine, University of Trondheim, Norway, 1987.
  37. Spreen O, Strauss E: A Compendium of Neuropsychological Tests. New York, Oxford University Press, 1998.
  38. Jennekens-Schinkel A, Sanders EACM, Lancer JBK, van der Velde EA: Reaction time in ambulant multiple sclerosis patients. 1. Influence of prolonged cognitive effort. J Neurol Sci 1988;85:173–186.
    External Resources
  39. Feinstein A, Kartsounis LD, Miller DH, Youl BD, Ron MA: Clinically isolated lesions of the type seen in multiple sclerosis: a cognitive, psychiatric, and MRI follow-up study. J Neurol Neurosurg Psychiatry 1992;55:869–876.
    External Resources
  40. Feinstein A, Ron M, Thompson A: A serial study of psychometric and magnetic resonance imaging changes in multiple sclerosis. Brain 1993;116:569–602.
    External Resources
  41. Feinstein A, Youl B, Ron M: Acute optic neuritis. A cognitive and magnetic resonance imaging study. Brain 1992;115:1403–1415.
    External Resources
  42. Kofler B: Visual and acoustic evoked potentials in multiple sclerosis. Wien Med Wochenschr 1985;135:35–38.
    External Resources
  43. Antal A, Aita JF, Bodis-Wollner I: The paracentral visual field in multiple sclerosis: evidence for a deficit in interneuronal spatial summation? Vision Res 2001;41:1735–1742.
    External Resources
  44. Foong J, Rosewicz L, Chong WK, Thompson AJ, Miller DH, Ron MA: A comparison of neuropsychological deficits in primary and secondary progressive multiple sclerosis. J Neurol 2000;247:97–101.
    External Resources
  45. Rao SM, Hammeke TA, McQuillen MP, Khatri BO, Lloyd D: Memory disturbance in chronic-progressive multiple sclerosis. Arch Neurol 1984;41:625–631.
    External Resources
  46. Heaton RK, Nelson LM, Thompson DS, Burk JS, Franklin GM: Neuropsychological findings in relapsing-remitting and chronic-progressive multiple sclerosis. J Consult Clin Psychol 1985;53:103–110.
    External Resources
  47. Beatty WW: Memory and frontal lobe dysfunction in multiple sclerosis. J Neurol Sci 1993;115(suppl):38–41.
    External Resources
  48. Beatty WW, Monson N: Problem solving by patients with multiple sclerosis: comparison of performance on the Wisconsin and California card sorting tests. J Int Neuropsychol Soc 1996;2:134–140.
    External Resources
  49. Demaree HA, Gaudino EA, DeLuca J, Ricker JH: Learning impairment is associated with recall ability in multiple sclerosis. J Clin Exp Neuropsychol 2000;22:865–873.
    External Resources
  50. Gaudino EA, Chiaravalloti ND, DeLuca J, Diamond BJ: A comparison of memory performance in relapsing-remitting, primary progressive and secondary progressive, multiple sclerosis. Neuropsychiatry Neuropsychol Behav Neurol 2001;14:32–44.
    External Resources
  51. Lyon-Caen O, Jouvent R, Hausen S, et al: Cognitive function in recent onset demyelinating diseases. Arch Neurol 1986;43:1138–1141.
    External Resources
  52. Kujala P, Portin R, Ruutiainen J: Memory deficits and early cognitive deterioration in MS. Acta Neurol Scand 1996;93:329–335.
    External Resources
  53. Thornton AE, Raz N, Tucker KA: Memory in multiple sclerosis: contextual encoding deficits. J Int Neuropsychol Soc 2002;8:395–409.
    External Resources
  54. Fennell EB, Smith MC: Neuropsychological assessment; in Rao SM (ed): Neurobehavioral Aspects of Multiple Sclerosis. New York, Oxford University Press, 1990, pp 63–81.
  55. Beatty WW, Hames KA, Blanco CR, Paul RH, Wilbanks SL: Verbal abstraction deficit in multiple sclerosis. Neuropsychology 1995;9:198–205.
    External Resources
  56. Rao SM: Neuropsychology of multiple sclerosis. A critical review. J Clin Exp Neuropsychol 1986;8:503–542.
    External Resources
  57. Comi G, Filippi M, Martinelli V, Campi A, Rodegher M, Alberoni M, Sirabian G, Canal N: Brain MRI correlates of cognitive impairment in primary and secondary progressive multiple sclerosis. J Neurol Sci 1995;132:222–227.
    External Resources
  58. Rao SM, Hammeke TA, Speech TJ: Wisconsin Card Sort Test performance in relapsing-remitting and chronic-progressive multiple sclerosis. J Consult Clin Psychol 1987;55:263–265.
    External Resources
  59. Beatty WW, Goodkin DE, Monson N, Beatty PA, Hertsgaard D: Anterograde and retrograde amnesia in patients with chronic-progressive multiple sclerosis. Arch Neurol 1988;45:611–619.
    External Resources
  60. Peyser JM, Edwards KR, Poser CM, Filskov SB: Cognitive function in patients with multiple sclerosis. Arch Neurol 1980;37:577–579.
    External Resources
  61. Rao SM, Glatt S Hammeke TA, McQuillen MP, Khatri BO, Rhodes AM, Pollard S: Chronic progressive multiple sclerosis. Relationship between cerebral ventricular size and neuropsychological impairment. Arch Neurol 1985;42:678–682.
    External Resources

Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: June 14, 2006
Accepted: November 01, 2006
Published online: January 31, 2007
Issue release date: May 2007

Number of Print Pages: 10
Number of Figures: 3
Number of Tables: 2

ISSN: 0014-3022 (Print)
eISSN: 1421-9913 (Online)

For additional information: https://www.karger.com/ENE

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2007, Vol.57, No. 4

May 2007

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