Multicentric Reticulohistiocytosis-Mimicking Dermatomyositis
Case Report and Review of the LiteratureMuñoz-Santos C.a · Sàbat M.a · Sáez A.b · Gratacós J.c · Luelmo J.a
aDermatology Unit and Departments of bPathology and cRheumatology, Hospital de Sabadell, Corporació Sanitària Parc Taulí, Sabadell, Spain
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Article / Publication Details
Multicentric reticulohistiocytosis is a rare disorder of unknown etiology, characterized by skin and mucosal papulonodular eruptions and destructive polyarthritis. Histopathological study of these lesions shows a nodular infiltrate composed of histiocytes and multinucleated giant cells, with an eosinophilic, granular, ‘ground-glass’ cytoplasm. We report a case of multicentric reticulohistiocytosis with skin lesions mimicking dermatomyositis and we also review previously reported cases describing such a clinical situation. Our case further emphasizes that multicentric reticulohistiocytosis can mimic clinical features of dermatomyositis. A macular or patch-like erythema in a photodistributed fashion, in addition to other clinical manifestations, can be mistaken for dermatomyositis. However, skin biopsies from these areas may early differentiate both conditions with different treatment options and morbidity.
© 2007 S. Karger AG, Basel
- Ehrlich GE, Young I, Nosheny SE, Katz WA: Multicentric reticulohistiocytosis (lipoid dermatoarthritis). Am J Med 1972;53:830–840.
- Trotta F, Castellino G, Lo Monaco A: Multicentric reticulohistiocytosis. Best Pract Res Clin Rheumatol 2004;18:759–772.
- Luz FB, Gaspar AP, Kalil-Gaspar N, Ramos-e-Silva M: Multicentric reticulohistiocytosis. J Eur Acad Dermatol Venereol 2001;15:524–531.
- Catterall MD: Multicentric reticulohistiocytosis: a review of eight cases. Clin Exp Dermatol 1980;5:267–279.
- Campbell DA, Edwards NL: Multicentric reticulohistiocytosis: systemic macrophage disorder. Baillieres Clin Rheumatol 1991;5:301–319.
- Barrow MV, Holubar K: Multicentric reticulohistiocytosis. A review of 33 patients. Medicine (Baltimore) 1969;48:287–305.
Ginsburg WW, O’Duffy JD: Multicentric reticulohistiocytosis; in Kelly WN, Harris ED Jr, Rudge S, et al (eds): Textbook of Rheumatology. Philadelphia, Saunders, 1985, pp 1502–1505.
- Gold KD, Sharp JT, Estrada RG, Duffy J, Person DA: Relationship between multicentric reticulohistiocytosis and tuberculosis. JAMA 1977;237:2213–2214.
- Conaghan P, Miller M, Dowling JP, Cowen P, Littlejohn G: A unique presentation of multicentric reticulohistiocytosis in pregnancy. Arthritis Rheum 1993;36:269–272.
- Giam YC, Ong BH: Multicentric reticulohistiocytosis. Ann Acad Med Singapore 1988;17:548–550.
- Rendall JR, Vanhegan RI, Robb-Smith AH, Bowers RE, Ryan TJ, Vickers HR: Atypical multicentric reticulohistiocytosis with paraproteinemia. Arch Dermatol 1977;113:1576–1582.
- Flaming JA, Weigand DA: Unusual case of multicentric reticulohistiocytosis. Int J Dermatol 1993;32:125–127.
Lehrer A, Bergero A, Soriano F: Reticulohistiocytosis multicentrica. Rev Argent Dermatol 1984;65:215–219.
- Sachs RN, Garnier J, Daupleix D, Kemeny JL, Amouroux J, Lanfranchi J: Réticulo-histiocytose multicentrique. Fistulisation cutanée. Nouv Presse Med 1982;11:1497.
- Kenik JG, Fok F, Huerter CJ, Hurley JA, Stanosheck JF: Multicentric reticulohistiocytosis in a patient with malignant melanoma: a response to cyclophosphamide and a unique cutaneous feature. Arthritis Rheum 1990;33:1047–1051.
- Hsu S, Ward SB, Le EH, Lee JB: Multicentric reticulohistiocytosis with neurofibroma-like nodules. J Am Acad Dermatol 2001;44(suppl):373–375.
- Tait TJ, Bird HA, Ford GP: Multicentric reticulohistiocytosis: presentation with the cutaneous features of dermatomyositis. Br J Rheumatol 1994;33:100–101.
- Hsiung SH, Chan EF, Elenitsas R, Kolasinski SL, Schumacher HR, Werth VP: Multicentric reticulohistiocytosis presenting with clinical features of dermatomyositis. J Am Acad Dermatol 2003;48(suppl):S11–S14.
- McIlwain KL, DiCarlo JB, Miller SB, Lim S: Multicentric reticulohistiocytosis with prominent cutaneous lesions and proximal muscle weakness masquerading as dermatomyositis. J Rheumatol 2005;32:193–194.
- Gajic-Veljic M, Nikolic MM, Bukilica M, Bonaci-Nikolic B: Multicentric reticulohistiocytosis. A case with minimal articular changes. J Eur Acad Dermatol Venereol 2006;20:108–110.
- Gao IK, Gorozny JJ, Weyand CM: Ten-year follow-up of a patient with multicentric reticulohistiocytosis associated with myopathy. Scand J Rheumatol 1990;19:437–441.
Du Vivier A: Atlas of Clinical Dermatology, ed 3. Edinburgh, Churchill Livingstone, 2002.
- Pei Lin Ng P, Lin Gan S: Koebner phenomenon in dermatomyositis. Dermatology 2006;213:249–250.
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