Psychotherapy and Psychosomatics

Innovations

How Does Our Brain Constitute Defense Mechanisms? First-Person Neuroscience and Psychoanalysis

Northoff G.a, c · Bermpohl F.c · Schoeneich F.b · Boeker H.d

Author affiliations

aDepartment of Psychiatry, Psychotherapy and Psychosomatics, University of Magdeburg, Magdeburg, and bDepartment of Psychosomatics, Humboldt University Charité, cDepartment of Psychiatry and Psychotherapy, Charité-University Medicine Berlin, Berlin, Germany; dDepartment of Psychiatry, University of Zurich, Zurich, Switzerland

Keywords: PsychoanalysisNeuroscienceDefense mechanismsNeuronal integrationCatatonia

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Psychother Psychosom 2007;76:141–153
https://doi.org/10.1159/000099841

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Article / Publication Details

First-Page Preview
Abstract of Innovations

Published online: April 05, 2007
Issue release date: April 2007

Number of Print Pages: 13
Number of Figures: 2
Number of Tables: 1

ISSN: 0033-3190 (Print)
eISSN: 1423-0348 (Online)

For additional information: https://www.karger.com/PPS

Abstract

Current progress in the cognitive and affective neurosciences is constantly influencing the development of psychoanalytic theory and practice. However, despite the emerging dialogue between neuroscience and psychoanalysis, the neuronal processes underlying psychoanalytic constructs such as defense mechanisms remain unclear. One of the main problems in investigating the psychodynamic-neuronal relationship consists in systematically linking the individual contents of first-person subjective experience to third-person observation of neuronal states. We therefore introduced an appropriate methodological strategy, ‘first-person neuroscience’, which aims at developing methods for systematically linking first- and third-person data. The utility of first-person neuroscience can be demonstrated by the example of the defense mechanism of sensorimotor regression as paradigmatically observed in catatonia. Combined psychodynamic and imaging studies suggest that sensorimotor regression might be associated with dysfunction in the neural network including the orbitofrontal, the medial prefrontal and the premotor cortices. In general sensorimotor regression and other defense mechanisms are psychoanalytic constructs that are hypothesized to be complex emotional-cognitive constellations. In this paper we suggest that specific functional mechanisms which integrate neuronal activity across several brain regions (i.e. neuronal integration) are the physiological substrates of defense mechanisms. We conclude that first-person neuroscience could be an appropriate methodological strategy for opening the door to a better understanding of the neuronal processes of defense mechanisms and their modulation in psychoanalytic psychotherapy.

© 2007 S. Karger AG, Basel



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References

  1. Freud S: The neuro-psychoses of defense; in Strachey J (ed): The Standard Edition of the Complete Psychological Works of Sigmund Freud. London, Hogarth, (original work published 1894), 1962, pp 43–68.
  2. Gazzaniga MS: Mark D’Esposito with Michael S. Gazzaniga. J Cogn Neurosci 2004;16:1–3.
    External Resources
  3. Panksepp J: Affective Neuroscience: The Foundations of Human and Animal Emotions. New York, Oxford University Press, 1998.
  4. Panksepp J: At the interface of the affective, behavioral and cognitive neurosciences: decoding the emotional feelings of the brain. Brain Cogn 2003;52:4–14.
    External Resources
  5. Damasio AR: How the brain creates the mind. Sci Am 1999;281:112–117.
    External Resources
  6. Solms M: What is consciousness? J Am Psychoanal Assoc 1997;45:681–703, discussion 704–778.
    External Resources
  7. Schore SE, Sumner CJ, Bledsoe SC, Lu J: Effects of contralateral sound stimulation on unit activity of ventral cochlear nucleus neurons. Exp Brain Res 2003;153:427–435.
    External Resources
  8. Schore SE, El Kashlan H, Lu J: Effects of trigeminal ganglion stimulation on unit activity of ventral cochlear nucleus neurons. Neuroscience 2003;119:1085–1101.
    External Resources
  9. Kandel ER: A new intellectual framework for psychiatry. Am J Psychiatry 1998;155:457–469.
    External Resources
  10. Kandel ER: Biology and the future of psychoanalysis: a new intellectual framework for psychiatry revisited. Am J Psychiatry 1999;156:505–524.
    External Resources
  11. Gabbard GO: Psychodynamic psychiatry in the ‘decade of the brain’. Am J Psychiatry 1992;149:991–998.
    External Resources
  12. Gabbard GO: Psychodynamics of panic disorder and social phobia. Bull Menninger Clin 1992;56(suppl 2A):A3–A13.
  13. Westen D, Gabbard GO: Developments in cognitive neuroscience. I. Conflict, compromise and connectionism. J Am Psychoanal Assoc 2002;50:53–98.
    External Resources
  14. Westen D, Gabbard GO: Developments in cognitive neuroscience. II. Implications for theories of transference. J Am Psychoanal Assoc 2002;50:99–134.
    External Resources
  15. Westen D: The scientific status of unconscious processes: is Freud really dead? J Am Psychoanal Assoc 1999;47:1061–1106.
    External Resources
  16. Brockman R: Toward a neurobiology of the unconscious. J Am Acad Psychoanal 2001;29:601–615.
    External Resources
  17. Beutel ME, Stern E, Silbersweig DA: The emerging dialogue between psychoanalysis and neuroscience: neuroimaging perspectives. J Am Psychoanal Assoc 2003;51:773–801.
    External Resources
  18. Solms M, Lechevalier B: Neurosciences and psychoanalysis. Int J Psychoanal 2002;83:233–237.
    External Resources
  19. Westen D: Implications of developments in cognitive neuroscience for psychoanalytic psychotherapy. Harv Rev Psychiatry 2002;10:369–373.
    External Resources
  20. Northoff G, Böker H, Richter A, Tempelmann C, Bogerts B, Heinze HJ: Emotional-behavioral disturbances in catatonia: a combined study of psychological self-evaluation and fMRI. Neuropsychoanalysis 2003;3:151–167.
  21. Northoff G: Phänomenale, tiefenpsychologische und neurowissenschaftliche Perspektiven der Katatonie: Eine epistemische Betrachtung; in Böker H (ed): Depression, Manie und schizoaffektive Psychosen. Giessen, Psychosozial-Verlag, 2000.
  22. Schneider P: Psychoanalyse und Neurowissenschaft: Inkompatibilität!; in Böker H (ed): Psychoanalyse und Psychiatrie – Geschichte, Krankheitsmodelle und Therapiepraxis. Heidelberg, Springer Medizin Verlag, 2006.
  23. Jones H: Preserve psychoanalysis from too much neuroscience. Br J Psychiatry 2003;182:552–553.
    External Resources
  24. Edelson SM: Implications of sensory stimulation in self-destructive behavior. Am J Ment Defic 1984;89:140–145.
    External Resources
  25. Gruenbaum A: Precis of The Foundations of Psychoanalysis: A Philosophical Critique. Behav Brain Sci 1986;9:217–284.
    External Resources
  26. McCrone J: Freud’s neurology. Lancet Neurol 2004;3:320.
    External Resources
  27. Pugh G: Freud’s ‘problem’: cognitive neuroscience and psychoanalysis working together on memory. Int J Psychoanal 2002;83:1375–1394.
    External Resources
  28. Anderson DL: You don’t need a licence (or PhD) to use your brain. Nature 2004;430:965.
    External Resources
  29. Anderson CS, Hackett ML, House AO: Interventions for preventing depression after stroke. Cochrane Database Syst Rev 2004;2: CD003689.
  30. Solms M, Turnbull OH, Kaplan-Solms K, Miller P: Rotated drawing: the range of performance and anatomical correlates in a series of 16 patients. Brain Cogn 1998;38:358–368.
    External Resources
  31. Bollas L: Der Schatten des Objekts: Das ungedachte Bekannte. Zur Psychoanalyse der frühen Entwicklung. Stuttgart, Klett-Cotta, 1997.
  32. Northoff G, Bermpohl F: Cortical midline structures and the self. Trends Cogn Sci 2004;8:102–107.
    External Resources
  33. Northoff G, Heinzel A, Bermpohl F, Niese R, Pfennig A, Pascual-Leone A, Schlaug G: Reciprocal modulation and attenuation in the prefrontal cortex: an fMRI study on emotional-cognitive interaction. Hum Brain Mapp 2004;21:202–212.
    External Resources
  34. Northoff G, Kotter R, Baumgart F, Danos P, Boeker H, Kaulisch T, Schlagenhauf F, Walter H, Heinzel A, Witzel T, Bogerts B: Orbitofrontal cortical dysfunction in akinetic catatonia: a functional magnetic resonance imaging study during negative emotional stimulation. Schizophr Bull 2004;30:405–427.
    External Resources
  35. Varela FJ, Shear J: First-person methodologies: what, why, how? J Consc Studies 1999a;6:1–14.
  36. Varela FJ, Shear J (eds): The views from within: first-person methodologies in the study of consciousness (special issue). J Consc Studies 1999b, vol 6.
  37. Northoff G: Philosophy of the Brain. The Brain Problem. Amsterdam, John Benjamins, 2004.
  38. Fava GA, Ruini C, Rafanelli C: Psychometric theory is an obstacle to the progress of clinical research. Psychother Psychosom 2004;73:145–148.
    External Resources
  39. Nierenberg AA, Sonino N: From clinical observations to clinimetrics: a tribute to Alvan R. Feinstein, MD. Psychother Psychosom 2004;73:131–133.
    External Resources
  40. Varela FJ: Neurophenomenologie: a methodological remedy for the hard problem. J Consc Studies 1996;3:330–349.
  41. Gabbard GO: The psychodynamic perspective: a conversation with Glen O. Gabbard, MD. Interview by Norine J Kerr. Perspect Psychiatr Care 1992;28:6–12.
    External Resources
  42. Northoff G: ‘Brain-paradox’ and ‘embeddment’ – Do we need a ‘philosophy of the brain’? Brain and Mind 2001;2:195–211.
    External Resources
  43. Weinryb RM, Rossel RJ, Asberg M: The Karolinska Psychodynamic Profile. II. Interdisciplinary and cross-cultural reliability. Acta Psychiatr Scand 1991;83:73–76.
    External Resources
  44. Weinryb RM, Rossel RJ, Asberg M: The Karolinska Psychodynamic Profile. I. Validity and dimensionality. Acta Psychiatr Scand 1991;83:64–72.
    External Resources
  45. Perry JC, Cooper SH: An empirical study of defense mechanisms. I. Clinical interview and life vignette ratings. Arch Gen Psychiatry 1989;46:444–452.
    External Resources
  46. Vaillant GE, Bond M, Vaillant CO: An empirically validated hierarchy of defense mechanisms. Arch Gen Psychiatry 1986;43:786–794.
    External Resources
  47. Kipper L, Blaya C, Teruchkin B, Heldt E, Isolan L, Mezzomo K, Bond M, Manfro GG: Brazilian patients with panic disorder: the use of defense mechanisms and their association with severity. J Nerv Ment Dis 2004;192:58–64.
    External Resources
  48. Andrews G, Singh M, Bond M: The Defense Style Questionnaire. J Nerv Ment Dis 1993;181:246–256.
    External Resources
  49. Shedler J, Westen D: Dimensions of personality pathology: an alternative to the five-factor model. Am J Psychiatry 2004;161:1743–1754.
    External Resources
  50. Shedler J, Westen D: Refining personality disorder diagnosis: integrating science and practice. Am J Psychiatry 2004;161:1350–1365.
    External Resources
  51. Smith N, Freeman D, Kuipers E: Delusions: an experimental investigation of the delusion as defence. J Nerv Ment Dis 2005;193:480–487.
    External Resources
  52. Wilkinson-Ryan T, Westen D: Identity disturbance in borderline personality disorder: an empirical investigation. Am J Psychiatry 2000;157:528–541.
    External Resources
  53. Schauenburg H, Schussler G, Leibing E: Empirical assessment of defense mechanisms with a self evaluation questionnaire (according to Bond et al.). Psychother Psychosom Med Psychol 1991;41:392–400.
    External Resources
  54. Schibuk M, Bond M, Bouffard R: The development of defenses in childhood. Can J Psychiatry 1989;34:581–588.
    External Resources
  55. Barglow P, Jaffe CM, Vaughn B: Psychoanalytic reconstructions and empirical data: reciprocal contributions. J Am Psychoanal Assoc 1989;37:401–435.
    External Resources
  56. Metzinger T: Being No One. The Self Model Theory of Subjectivity. Cambridge, MIT Press, 2003.
  57. Chomsky N: Universals of human nature. Psychother Psychosom 2005;74:263–268.
    External Resources
  58. Bush G, Fink M, Petrides G, Dowling F, Francis A: Catatonia. II. Treatment with lorazepam and electroconvulsive therapy. Acta Psychiatr Scand 1996;93:137–143.
    External Resources
  59. Bush G, Fink M, Petrides G, Dowling F, Francis A: Catatonia. I. Rating scale and standardized examination. Acta Psychiatr Scand 1996;93:129–136.
    External Resources
  60. Fink M: Catatonia and psychotic (delusional) depression, distinct syndromes in DSM-IV. Am J Psychiatry 1993;150:1130–1131.
    External Resources
  61. Northoff G: What catatonia can tell us about ‘top-down modulation’: a neuropsychiatric hypothesis. Behav Brain Sci 2002;25:555–577, discussion 578–604.
    External Resources
  62. Northoff G: Catatonia and neuroleptic malignant syndrome: psychopathology and pathophysiology. J Neural Transm 2002;109:1453–1467.
    External Resources
  63. Taylor MA: Catatonia: a review of the behavioral neurologic syndrome. Neuropsychiatry Neuropsychol Behav Neurol 1990;3:48–72.
  64. Perkins K: Catatonia as an immobilization reflex. Aust NZ J Psychiatry 1982;23:282–288.
    External Resources
  65. Böker H, Lempa G: Psychosen; in Senf W, Broda M (eds): Praxis der Psychotherapie. Ein integratives Lehrbuch. Stuttgart, Thieme, 1996.
  66. Johnson DR: Representation of the internal world in catatonic schizophrenia. Psychiatry 1984;47:299–314.
    External Resources
  67. Arieti S: Volition and value: a study based on catatonic schizophrenia; in Post SC (ed): Moral Values and the Superego Concept in Psychoanalysis. New York, International Universities Press, 1972.
  68. Boeker H: Selbstbild und Objektbeziehungen bei Depressionen. Untersuchungen mit der Repertory Grid Technique und dem Giessen Test an 139 Patienten mit depressiven Erkrankungen. Darmstadt, Steinkopf, 1999.
  69. Kelly GA: The Psychology of Personal Constructs. New York, Norton, 1955, vol I and II.
  70. Winter DA: Repertory grid technique in the evaluation pf therapeutic outcome; in Beail N (ed): Repertory Grid Technique and Personal Constructs. London, Croom Helm, 1985, pp 154–172.
  71. Winter DA: Personal Construct Theory in Clinical Practice. London, Routledge, 1992.
  72. Böker H, Budischewski K, Eppel A, Härtling F, Rinnert H, von Schmeling F, Will H, Schöneich F, Northoff G: Personality and object relations in patients with affective disorders: ideographic research by means of the repertory grid technique. J Affect Disord 2000;60:53–59.
    External Resources
  73. Böker H: Persons with depression, mania and schizoaffective psychosis: Investigations of cognitive complexity, self-esteem, social perception and object relations by means of the repertory grid-technique; in Klapp BP, Jordan J, Walter OB (eds): Role Repertory Grid and Body Grid – Construct Psychological Approaches in Psychosomatic Research. Frankfurt/M., VAS – Verlag für Akademische Schriften, Reihe Klinische Psycholinguistik, 2004, pp 119–146.
  74. Northoff G, Witzel T, Richter A, Gessner M, Schlagenhauf F, Fell J, Baumgart F, Kaulisch T, Tempelmann C, Heinzel A, Kotter R, Hagner T, Bargel B, Hinrichs H, Bogerts B, Scheich H, Heinze HJ: GABA-ergic modulation of prefrontal spatio-temporal activation pattern during emotional processing: a combined fMRI/MEG study with placebo and lorazepam. J Cogn Neurosci 2002;14:348–370.
    External Resources
  75. Goel V, Dolan RJ: Explaining modulation of reasoning by belief. Cognition 2003;87:B11–B22.
    External Resources
  76. Goel V, Dolan RJ: Reciprocal neural response within lateral and ventral medial prefrontal cortex during hot and cold reasoning. Neuroimage 2003;20:2314–2321.
    External Resources
  77. Johnson PA, Hurley RA, Benkelfat C, Herpertz SC, Taber KH: Understanding emotion regulation in borderline personality disorder: contributions of neuroimaging. J Neuropsychiatry Clin Neurosci 2003;15:397–402.
    External Resources
  78. Tebartz van Elst L, Hesslinger B, Thiel T, Geiger E, Haegele K, Lemieux L, Lieb K, Bohus M, Hennig J, Ebert D: Frontolimbic brain abnormalities in patients with borderline personality disorder: a volumetric magnetic resonance imaging study. Biol Psychiatry 2003;54:163–171.
    External Resources
  79. Vollm B, Richardson P, Stirling J, Elliott R, Dolan M, Chaudhry I, Del Ben C, McKie S, Anderson I, Deakin B: Neurobiological substrates of antisocial and borderline personality disorder: preliminary results of a functional fMRI study. Crim Behav Ment Health 2004;14:39–54.
    External Resources
  80. Friston KJ, Josephs O, Rees G, Turner R: Nonlinear event-related responses in fMRI. Magn Reson Med 1998;39:41–52.
    External Resources
  81. Friston KJ, Fletcher P, Josephs O, Holmes A, Rugg MD, Turner R: Event-related fMRI: characterizing differential responses. Neuroimage 1998;7:30–40.
    External Resources
  82. Friston KJ: Imaging neuroscience: principles or maps? Proc Natl Acad Sci USA 1998;95:796–802.
    External Resources
  83. Friston K: Learning and inference in the brain. Neural Netw 2003;16:1325–1352.
    External Resources
  84. Friston KJ, Harrison L, Penny W: Dynamic causal modelling. Neuroimage 2003;19:1273–1302.
    External Resources
  85. Friston KJ, Penny W: Posterior probability maps and SPMs. Neuroimage 2003;19:1240–1249.
    External Resources
  86. Friston KJ, Price CJ: Degeneracy and redundancy in cognitive anatomy. Trends Cogn Sci 2003;7:151–152.
    External Resources
  87. Gusnard DA, Raichle ME: Searching for a baseline: functional imaging and the resting human brain. Nat Rev Neurosci 2001;2:685–694.
    External Resources
  88. Gusnard DA, Akbudak E, Shulman GL, Raichle ME: Medial prefrontal cortex and self-referential mental activity: relation to a default mode of brain function. Proc Natl Acad Sci USA 2001;98:4259–4264.
    External Resources
  89. Raichle ME: Cognitive neuroscience: bold insights. Nature 2001;412:128–130.
    External Resources
  90. Raichle ME, MacLeod AM, Snyder AZ, Powers WJ, Gusnard DA, Shulman GL: A default mode of brain function. Proc Natl Acad Sci USA 2001;98:676–682.
    External Resources
  91. Mazoyer B, Zago L, Mellet E, Bricogne S, Etard O, Houde O, Crivello F, Joliot M, Petit L, Tzourio-Mazoyer N: Cortical networks for working memory and executive functions sustain the conscious resting state in man. Brain Res Bull 2001;54:287–298.
    External Resources
  92. Greicius MD, Krasnow B, Reiss AL, Menon V: Functional connectivity in the resting brain: a network analysis of the default mode hypothesis. Proc Natl Acad Sci USA 2003;100:253–258.
    External Resources
  93. Wicker B, Ruby P, Royet JP, Fonlupt P: A relation between rest and the self in the brain? Brain Res Brain Res Rev 2003;43:224–230.
    External Resources
  94. Wicker B, Keysers C, Plailly J, Royet JP, Gallese V, Rizzolatti G: Both of us disgusted in my insula: the common neural basis of seeing and feeling disgust. Neuron 2003;40:655–664.
    External Resources
  95. Wicker B, Perrett DI, Baron-Cohen S, Decety J: Being the target of another’s emotion: a PET study. Neuropsychologia 2003;41:139–146.
    External Resources
  96. Kelley WM, Macrae CN, Wyland CL, Caglar S, Inati S, Heatherton TF: Finding the self? An event-related fMRI study. J Cogn Neurosci 2002;14:785–794.
    External Resources
  97. Marshall JC, Halligan PW, Fink GR, Wade DT, Frackowiak RS: The functional anatomy of a hysterical paralysis. Cognition 1997;64:B1–B8.
    External Resources
  98. Vuilleumier P, Chicherio C, Assal F, Schwartz S, Slosman D, Landis T: Functional neuroanatomical correlates of hysterical sensorimotor loss. Brain 2001;124:1077–1090.
    External Resources
  99. Halligan PW, Athwal BS, Oakley DA, Frackowiak RS: Imaging hypnotic paralysis: implications for conversion hysteria. Lancet 2000;355:986–987.
    External Resources
  100. Spence SA, Crimlisk HL, Cope H, Ron MA, Grasby PM: Discrete neurophysiological correlates in prefrontal cortex during hysterical and feigned disorder of movement. Lancet 2000;355:1243–1244.
    External Resources
  101. Modestin J, Bachmann KM: A third kind of psychosis. Analysis of the literature. Schweiz Arch Neurol Psychiatr 1992;143:307–323.
    External Resources
  102. Modestin J, Bachmann KM: Is the diagnosis of hysterical psychosis justified? Clinical study of hysterical psychosis, reactive/psychogenic psychosis and schizophrenia. Compr Psychiatry 1992;33:17–24.
    External Resources
  103. Northoff G, Eckert J, Fritze J: Glutamatergic dysfunction in catatonia? Successful treatment of three acute akinetic catatonic patients with the NMDA antagonist amantadine. J Neurol Neurosurg Psychiatry 1997;62:404–406.
    External Resources
  104. Lanius RA, Williamson PC, Bluhm RL, Densmore M, Boksman K, Neufeld RW, Gati JS, Menon RS: Functional connectivity of dissociative responses in posttraumatic stress disorder: a functional magnetic resonance imaging investigation. Biol Psychiatry 2005;57:873–884.
    External Resources
  105. Northoff G, Richter A, Gessner M, Schlagenhauf F, Fell J, Baumgart F, Kaulisch T, Kotter R, Stephan KE, Leschinger A, Hagner T, Bargel B, Witzel T, Hinrichs H, Bogerts B, Scheich H, Heinze HJ: Functional dissociation between medial and lateral prefrontal cortical spatiotemporal activation in negative and positive emotions: a combined fMRI/MEG study. Cereb Cortex 2000;10:93–107.
    External Resources
  106. Tononi G, Edelman GM: Schizophrenia and the mechanisms of conscious integration. Brain Res Brain Res Rev 2000;31:391–400.
    External Resources

Article / Publication Details

First-Page Preview
Abstract of Innovations

Published online: April 05, 2007
Issue release date: April 2007

Number of Print Pages: 13
Number of Figures: 2
Number of Tables: 1

ISSN: 0033-3190 (Print)
eISSN: 1423-0348 (Online)

For additional information: https://www.karger.com/PPS

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