This study examined the ability of neurologically healthy individuals and individuals with Alzheimer’s disease (AD) to successfully complete procedures involving short-term spatial visuomotor memory tasks, and tasks involving increasingly complex visuomotor transformations. Participants made sliding finger movements over a clear touch-sensitive screen on two separate spatial planes (vertical and horizontal), to visually constant and remembered target positions. Significant main effects were observed between participant groups on reaction time and movement time measures. As well, significant changes in reaction time and movement time were observed within the patient group over the different of any experimental procedures. In addition, as task increased in complexity significant increases in errors were observed in the AD group. Overall, the results reveal that AD patients show substantial declines in their ability to process and integrate visual information to produce motor responses. Therefore, we believe that this psychophysical research provides further evidence that AD, even early stages of AD, can affect anatomical regions supporting vision for action.

Keywords:
Alzheimer’s disease, Visuomotor transformation, Visuomotor ability
1.
Batista AP, Andersen RA: The parietal reach region codes the next planned movement in a sequential reach task. J Neurophysiol 2001;85:539–544.
2.
Batista AP, Buneo CA, Snyder LH, Andersen RA: Reach plans in eye-centered coordinates. Science 1999;285:257–260.
3.
Caminiti R, Ferraina S, Mayer AB: Visuomotor transformations: early cortical mechanisms of reaching. Curr Opin Neurobiol 1998;8:753–761.
4.
Ghilardi MF, Alberoni M, Rossi M, Franceschi M, Mariani C, Fazio F: Visual feedback has differential effects on reaching movements in Parkinson’s and Alzheimer’s disease. Brain Res 2000;876:112–123.
5.
Ghilardi MF, Gordon J, Ghez C: Learning a visuomotor transformation in a local area of work space produces directional biases in other areas. J Neurophysiol 1995;73:2535–2539.
6.
Gordon J, Ghilardi MF, Cooper SE, Ghez C: Accuracy of planar reaching movements. II. Systematic extent errors resulting from inertial anisotropy. Exp Brain Res 1994;99:112–130.
7.
Soechting JF, Flanders M: Sensorimotor representations for pointing to targets in three-dimensional space. J Neurophysiol 1989;62:582–594.
8.
Soechting JF, Flanders M: Errors in pointing are due to approximations in sensorimotor transformations. J Neurophysiol 1989;62:595–608.
9.
Gorbet DJ, Staines WR, Sergio LE: Brain mechanisms for preparing increasingly complex sensory to motor transformations. Neuroimage 2004;23:1100–1111.
10.
Wise SP, di Pellegrino G, Boussaoud D: The premotor cortex and nonstandard sensorimotor mapping. Can J Physiol Pharmacol 1996;74:469–482.
11.
Ghilardi MF, Alberoni M, Marelli S, Rossi M, Franceschi M, Ghez C, Fazio F: Impaired movement control in Alzheimer’s disease. Neurosci Lett 1999;260:45–48.
12.
Levinoff EJ, Li KZ, Murtha S, Chertkow H: Selective attention impairments in Alzheimer’s disease: evidence for dissociable components. Neuropsychology 2004;18:580–588.
13.
Tippett WJ, Sergio LE: Visuomotor integration is impaired in early stage Alzheimer’s disease. Brain Res 2006;1102:92–102.
14.
Engler H, Forsberg A, Almkvist O, Blomquist G, Larsson E, Savitcheva I, Wall A, Ringheim A, Langstrom B, Nordberg A: Two-year follow-up of amyloid deposition in patients with Alzheimer’s disease. Brain 2006;129:2856–2866.
15.
Folstein MF, Folstein SE, McHugh PR: Mini-mental state. A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975;12:189–198.
16.
McKhann G, Drachman D, Folstein M, Katzman R, Price D, Stadlan EM: Clinical diagnosis of Alzheimer’s disease: report of the NINCDS-ADRDA Work Group under the auspices of Department of Health and Human Services Task Force on Alzheimer’s Disease. Neurology 1984;34:939–944.
17.
Perez FI, Rivera VM, Meyer JS, Gay JR, Taylor RL, Mathew NT: Analysis of intellectual and cognitive performance in patients with multi-infarct dementia, vertebrobasilar insufficiency with dementia, and Alzheimer’s disease. J Neurol Neurosurg Psychiatr 1975;38:533–540.
18.
Simone PM, Baylis GC: The role of attention in a spatial memory task in Alzheimer disease patients. Alzheimer Dis Assoc Disord 1997;11:140–152.
19.
Chong RK, Horak FB, Frank J, Kaye J: Sensory organization for balance: specific deficits in Alzheimer’s but not in Parkinson’s disease. J Gerontol A Biol Sci Med Sci 1999;54:M122–M128.
20.
Elble RJ, Leffler K: Pushing and pulling with the upper extremities while standing: the effects of mild Alzheimer dementia and Parkinson’s disease. Mov Disord 2000;15:255–268.
21.
Ghilardi MF, Alberoni M, Marelli S, Rossi M, Franceschi M, Ghez C, Fazio F: Impaired movement control in Alzheimer’s disease. Neurosci Lett 1999;260:45–48.
22.
Kluger A, Gianutsos JG, Golomb J, Ferris SH, George AE, Franssen E, Reisberg B: Patterns of motor impairment in normal aging, mild cognitive decline, and early Alzheimer’s disease. J Gerontol B Psychol Sci Soc Sci 1997;52:P28–P39.
23.
Ott BR, Ellias SA, Lannon MC: Quantitative assessment of movement in Alzheimer’s disease. J Geriatr Psychiatry Neurol 1995;8:71–75.
24.
Morris JC, Rubin EH, Morris EJ, Mandel SA: Senile dementia of the Alzheimer’s type: an important risk factor for serious falls. J Gerontol 1987;42:412–417.
25.
Duhamel JR, Colby CL, Goldberg ME: The updating of the representation of visual space in parietal cortex by intended eye movements. Science 1992;255:90–92.
26.
Ghilardi MF, Alberoni M, Rossi M, Franceschi M, Mariani C, Fazio F: Visual feedback has differential effects on reaching movements in Parkinson’s and Alzheimer’s disease. Brain Res 2000;876:112–123.
27.
Alexander NB, Mollo JM, Giordani B, Ashton-Miller JA, Schultz AB, Grunawalt JA, Foster NL: Maintenance of balance, gait patterns, and obstacle clearance in Alzheimer’s disease. Neurology 1995;45:908–914.
28.
Bellgrove MA, Phillips JG, Bradshaw JL, Hall KA, Presnell I, Hecht H: Response programming in dementia of the Alzheimer type: a kinematic analysis. Neuropsychologia 1997;35:229–240.
29.
Moscovitch C, Kapur S, Kohler S, Houle S: Distinct neural correlates of visual long-term memory for spatial location and object identity: a positron emission tomography study in humans. Proc Natl Acad Sci USA 1995;92:3721–3725.
30.
Ricciardi E, Bonino D, Gentili C, Sani L, Pietrini P, Vecchi T: Neural correlates of spatial working memory in humans: a functional magnetic resonance imaging study comparing visual and tactile processes. Neuroscience 2006;139:339–349.
31.
Medendorp WP, Goltz HC, Vilis T, Crawford JD: Gaze-centered updating of visual space in human parietal cortex. J Neurosci 2003;23:6209–6214.
32.
Andersen RA, Buneo CA: Intentional maps in posterior parietal cortex. Annu Rev Neurosci 2002;25:189–220.
33.
Andersen RA, Snyder LH, Bradley DC, Xing J: Multimodal representation of space in the posterior parietal cortex and it’s use in planning movements. Ann Rev Neurosci 1997;20:303–330.
34.
Snyder LH, Batista AP, Andersen RA: Change in motor plan, without a change in the spatial locus of attention, modulates activity in posterior parietal cortex. J Neurophysiol 1998;79:2814–2819.
35.
Kalaska JF: Parietal cortex area 5 and visuomotor behavior. Can J Physiol Pharmacol 1996;74:483–498.
36.
Braak H, Braak E: Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol 1991;82:239–259.
37.
Kitamura S, Terashi A: Measurements of cerebral blood flow and metabolism in patients with Alzheimer’s disease (in Japanese). Rinsho Byori 1990;38:494–498.
38.
Pennisi G, Alagona G, Ferri R, Greco S, Santonocito D, Pappalardo A, Bella R: Motor cortex excitability in Alzheimer disease: one year follow-up study. Neurosci Lett 2002;329:293–296.
39.
Hamzei F, Dettmers C, Rijntjes M, Glauche V, Kiebel S, Weber B, Weiller C: Visuomotor control within a distributed parieto-frontal network. Exp Brain Res 2002;146:273–281.
40.
Imran MB, Kawashima R, Awata S, Sato K, Kinomura S, Ono S, Yoshioka S, Sato M, Fukuda H: Parametric mapping of cerebral blood flow deficits in Alzheimer’s disease: a SPECT study using HMPAO and image standardization technique. J Nucl Med 1999;40:244–249.
41.
Buneo CA, Jarvis MR, Batista AP, Andersen RA: Direct visuomotor transformations for reaching. Nature 2002;416:632–636.
42.
Caminiti R, Ferraina S, Mayer AB: Visuomotor transformations: early cortical mechanisms of reaching. Curr Opin Neurobiol 1998;8:753–761.
43.
Belanger HG, Wilder-Willis K, Malloy P, Salloway S, Hamman RF, Grigsby J: Assessing motor and cognitive regulation in AD, MCI, and controls using the Behavioral Dyscontrol Scale. Arch Clin Neuropsychol 2005;20:183–189.
44.
von Gunten A, Bouras C, Kovari E, Giannakopoulos P, Hof PR: Neural substrates of cognitive and behavioral deficits in atypical Alzheimer’s disease. Brain Res Brain Res Rev 2006;51:176–211.
45.
Constantinidis C, Steinmetz MA: Neuronal activity in posterior parietal area 7a during the delay periods of a spatial memory task. J Neurophysiol 1996;76:1352–1355.
46.
Constantinidis C, Steinmetz MA: Posterior parietal cortex automatically encodes the location of salient stimuli. J Neurosci 2005;25:233–238.
47.
Oyachi H, Ohtsuka K: Transcranial magnetic stimulation of the posterior parietal cortex degrades accuracy of memory-guided saccades in humans. Invest Ophthalmol Vis Sci 1995;36:1441–1449.
48.
Wise SP, di Pellegrino G, Boussaoud D: The premotor cortex and nonstandard sensorimotor mapping. Can J Physiol Pharmacol 1996;74:469–482.
49.
Gerloff C, Corwell B, Chen R, Hallett M, Cohen LG: The role of the human motor cortex in the control of complex and simple finger movement sequences. Brain 1998;121:1695–1709.
50.
Wexler BE, Fulbright RK, Lacadie CM, Skudlarski P, Kelz MB, Constable RT, Gore JC: An fMRI study of the human cortical motor system response to increasing functional demands. Magn Reson Imaging 1997;15:385–396.
51.
Danckert J, Revol P, Pisella L, Krolak-Salmon P, Vighetto A, Goodale MA, Rossetti Y: Measuring unconscious actions in action-blindsight: exploring the kinematics of pointing movements to targets in the blind field of two patients with cortical hemianopia. Neuropsychologia 2003;41:1068–1081.
52.
Hof PR, Archin N, Osmand AP, Dougherty JH, Wells C, Bouras C, Morrison JH: Posterior cortical atrophy in Alzheimer’s disease: analysis of a new case and re-evaluation of a historical report. Acta Neuropathol 1993;86:215–223.
53.
Rossetti Y, Revol P, McIntosh R, Pisella L, Rode G, Danckert J, Tilikete C, Dijkerman HC, Boisson D, Vighetto A, Michel F, Milner AD: Visually guided reaching: bilateral posterior parietal lesions cause a switch from fast visuomotor to slow cognitive control. Neuropsychologia 2005;43:162–177.
54.
Rushworth MF, Nixon PD, Passingham RE: Parietal cortex and movement. I. Movement selection and reaching. Exp Brain Res 1997;117:292–310.
55.
Scahill RI, Schott JM, Stevens JM, Rossor MN, Fox NC: Mapping the evolution of regional atrophy in Alzheimer’s disease: unbiased analysis of fluid-registered serial MRI. Proc Natl Acad Sci USA 2002;99:4703–4707.
56.
Foster NL, Chase TN, Mansi L, Brooks R, Fedio P, Patronas NJ, Di Chiro G: Cortical abnormalities in Alzheimer’s disease. Ann Neurol 1984;16:649–654.
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