Plasma concentrations of immunoreactive growth hormone (GH) and of 17-hydroxycorticosteroids (17OH-CS) were measured during electrical stimulation of hypothalamus or hippocampus in 6 conscious monkeys adapted to chronic restraint in primate chairs. Plasma GH and 17OH-CS increased during 13/14 hypothalamic stimulation experiments. During hippocampal stimulation, however, changes of plasma GH and 17OH-CS were variable. In 6 of 12 hippocampal experiments the qualitative change of plasma 17OH-CS differed from that of GH. These dissociated hormonal changes during hippocampal stimulation are evidence that the central neurological control systems for GH and ACTH are functionally distinct. When the GH and 17OH-CS changes were correlated with the behavior elicited by brain stimulation rather than with the site of stimulation, peak increases of GH, but not of 17OH-CS, were significantly greater during behavior characterized by pupillary dilatation or vigorous attempts to escape from the primate chair than during simple ‘alerting’ behavior. This suggests that plasma GH may reflect the intensity of the central excitatory state better than plasma 17OH-CS.

Keywords:
Growth hormone, Adrenocorticotropic hormone, 17-Hydroxycorticosteroids, Monkey, Brain stimulation, Stress, Hypothalamus, Hippocampus, Emotional behavior
This content is only available via PDF.
© 1971 S. Karger AG, Basel
1971
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
You do not currently have access to this content.