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Neuroendocrinology 1990;52:243–248
(DOI:10.1159/000125593)

Effects of Phosphatidylserine on the Neuroendocrine Response to Physical Stress in Humans

Monteleone P.a · Beinat L.b · Tanzillo C.a · Maj M.a · Kemali D.a

Author affiliations

aInstitute of Medical Psychology and Psychiatry, First Medical School, University of Naples; bFIDIA Research Laboratories, Abano Terme, Italy

Corresponding Author

Palmiero Monteleone, MD, Institute of Medical Psychology and Psychiatry,.First Medical School, University of Naples, Largo Madonna delle Grazie, ex-villa Chiara, I-80138 Naples (Italy)

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Abstract

The activity of brain cortex-derived phosphatidylserine (BC-PS) on the neuroendocrine and neurovegetative responses to physical stress was tested in 8 healthy men who underwent three experiments with a bicycle ergometer. According to a double-blind design, before starting the exercise, each subject received intravenously, within 10 min, 50 or 75 mg of BC-PS or a volume-matched placebo diluted in 100 ml of saline. Blood samples were collected before and after the exercise for plasma epinephrine (E), norepinephrine (NE), dopamine (DA), adrenocorticotropin (ACTH), cortisol, growth hormone (GH), prolactin (PRL) and glucose determinations. Blood pressure and heart rate were also recorded. Physical stress induced a clear-cut increase in plasma E, NE, ACTH, cortisol, GH and PRL, whereas no significant change was observed in plasma DA and glucose. Pretreatment with both 50 and 75 mg BC-PS significantly blunted the ACTH and cortisol responses to physical stress.

© 1990 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: October 11, 1989
Accepted: February 26, 1990
Published online: April 03, 2008

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 0

ISSN: 0028-3835 (Print)
eISSN: 1423-0194 (Online)

For additional information: http://www.karger.com/NEN


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