Login to MyKarger

New to MyKarger? Click here to sign up.

Login with Facebook

Forgot your password?

Authors, Editors, Reviewers

For Manuscript Submission, Check or Review Login please go to Submission Websites List.

Submission Websites List

Institutional Login
(Shibboleth or Open Athens)

For the academic login, please select your country in the dropdown list. You will be redirected to verify your credentials.

Dermatology 1999;198:164–166

Acanthosis nigricans with Severe Obesity, Insulin Resistance and Hypothyroidism: Improvement by Diet Control

Kuroki R.a · Sadamoto Y.b · Imamura M.b · Abe Y.b · Higuchi K.b · Kato K.b · Koga T.c · Furue M.d

Author affiliations

Divisions of aDermatology and bInternal Medicine, National Kokura Hospital, Kitakyushu, Departments of Dermatology cSchool of Medicine, Fukuoka University, and dKyushu University, Faculty of Medicine, Fukuoka, Japan

Corresponding Author

Rie Kuroki, MD, PhD

Division of Dermatology, National Kokura Hospital

Harugaoka 10-1, Kokura-minami-ku

Kitakyushu 802-8533 (Japan)

Tel. +81 93 921 8881, Fax +81 93 922 5072

Do you have an account?

Login Information

Contact Information

By signing up for MyKarger you will automatically participate in our year-End raffle.
If you Then Do Not wish To participate, please uncheck the following box.

Yes, I wish To participate In the year-End raffle And Get the chance To win some Of our most interesting books, And other attractive prizes.

I have read the Karger Terms and Conditions and agree.


We report on a 27-year-old man with acanthosis nigricans (AN) associated with severe obesity, insulin resistance and hypothyroidism. A very low-calory diet treatment decreased his weight and then ameliorated the insulin-resistant state. These effects were followed by remarkable improvement of the AN prior to the correction of the hypothyroidism. This confirms that AN may be mainly attributed to insulin resistance rather than hypothyroidism per se.


  1. Kahn CR, Flier JS, Bar RS, Archer JA, Gorden P, Martin MM, Roth J: The syndromes of insulin resistance and acanthosis nigricans Insulin-receptor disorders in man. N Engl J Med 1976;294:739–745.
  2. Barth JH, Ng LL, Wojnarowska F, Dawber RPR: Acanthosis nigricans, insulin resistance and cutaneous virilism. Br J Dermatol 1988; 118:613–619.
    External Resources
  3. Rendon MI, Cruz PD, Sontheimer RD, Bergstresser PR: Acanthosis nigricans: A cutaneous marker of tissue resistance to insulin. J Am Acad Dermatol 1989;21:461–469.
    External Resources
  4. Flier JS: Metabolic importance of acanthosis nigricans. Arch Dermatol 1985;121:193–194.
  5. Cruz PD, Hud JA: Excess insulin binding to insulin-like growth factor receptors: Proposed mechanism for acanthosis nigricans. J Invest Dermatol 1992;98:82S–85S.
  6. Moller DE, Flier JS: Insulin resistance – Mechanisms, syndromes, and implications. N Engl J Med 1991;325:938–948.
  7. Matsuoka LY, Wortsman J, Gavin JR, Goldman J: Spectrum of endocrine abnormalities associated with acanthosis nigricans. Am J Med 1987;83:719–725.
    External Resources
  8. Ober KP: Acanthosis nigricans and insulin resistance associated with hypothyroidism. Arch Dermatol 1985;121:229–231.
  9. Matsuoka LY, Wortsman J, Gavin JR, Kupchella CE, Dietrich JG: Acanthosis nigricans, hypothyroidism, and insulin resistance. Am J Med 1986;81:58–62.

Article / Publication Details

First-Page Preview
Abstract of Case Report

Published online: April 26, 1999

Number of Print Pages: 3
Number of Figures: 3
Number of Tables: 0

ISSN: 1018-8665 (Print)
eISSN: 1421-9832 (Online)

For additional information: https://www.karger.com/DRM