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Chemotherapy 1971;16:345–355

Choleretics and Biliary Excretion of Antibiotics in Rats

Coppi G. · Monti L. · Genova R.

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Department of Microbiology, Research Laboratories of the ‘Istituto De Angeli’, Milan

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Authors’ address: Dr. G. Coppi, Dr. L. Monti, and Dr. R. Genova, Department, of Microbiology, Research Laboratories of ‘Istituto de Angeli’, Via Serio 15, 20139 Milan (Italy). – Request reprints from Dr. G. Coppi

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αα-Diethyl-1-naphthylacetic acid (DA 808) and α-methyl-α-(2-morpholinoethyl)-1-naphthylacetic acid (DA1627) are compared with dehydrocholic acid for activity on biliary excretion of penicillin G, ampicillin, methicillin, rifamycin SV, tetracycline and demethylchlortetracycline in rats. Unlike to dehydrocholic acid, DA 808 and DA 1627 do not decrease the concentrations of penicillins and tetracycline in the bile. The concentrations of rifamycin SV and demethylchlortetracycline are partially reduced by the two naphthylacetic acid derivatives and markedly reduced by dehydrocholic acid. DA 808 and DA 1627 increase, however, the total amount of the penicillins and tetracycline excreted in the bile but not that of demethylchlortetracycline and rifamycin SV. Dehydrocholic acid does not increase the amount of the antibiotics excreted in the bile. On the basis of these results some remarks of clinical therapy about the association of choleretics-antibiotics in the biliary infections are made.

© 1971 S. Karger AG, Basel

Article / Publication Details

First-Page Preview
Abstract of Pharmacology, Pharmacokinetics, Toxicology

Published online: May 19, 2009

Number of Print Pages: 11
Number of Figures: 0
Number of Tables: 0

ISSN: 0009-3157 (Print)
eISSN: 1421-9794 (Online)

For additional information: http://www.karger.com/CHE

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