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Dermatology 1997;195:362–368

Effects of Topically Applied Antioxidants in Experimentally Provoked Polymorphous Light Eruption

Hadshiew I.a · Stäb F.b · Untiedt S.b · Bohnsack K.b · Rippke F.b · Hölzle E.c

Author affiliations

aDepartment of Dermatology, University Hospital Hamburg, bBeiersdorf AG, Hamburg, and cDepartment of Dermatology, Municipal Hospital Oldenburg, Germany

Corresponding Author

I. Hadshiew, MD, Department of Dermatology, University Hospital Hamburg-Eppendorf, Martinistrasse 52, D–20246 Hamburg (Germany), Tel. +49 40 4717 2646, Fax +49 40 4717 4276

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Background: Polymoφhous light eruption (PLE) is the most common photodermatosis, with a prevalence of 10–20% in Western European countries and in the USA. Only few preventive measures for PLE exist, while its etiology and pathogenesis are still elusive. Recent theories on pathogenesis discuss the possible influence of oxidative stress. Objective: The presented randomized, placebo-controlled, double-blind study examines for the first time the protective effect of 3 different topically applied antioxidative preparations in experimentally photo-induced PLE. Method: 30 patients with a history of PLE underwent photoprovocation after having had applied 3 different formulations with antioxidants and one formulation with the vehicle only to the extensor surface of their upper arms, representing the individual site of predilection, twice daily for 1 week prior to and during the consecutive week of photoprovocation. The antioxidants used were combinations of different concentrations of α-glycosylrutin, ferulic acid and tocopheryl acetate. Results: Evaluation after the 4th photoprovocation revealed that the development and severity of PLE and concomitant pruritus were significantly reduced by the application of distinct combinations of antioxidants. Conclusion: The results offer a new insight into possible pathomechanisms of PLE and suggest a new approach for preventive and therapeutic measures.

© 1997 S. Karger AG, Basel

Article / Publication Details

First-Page Preview
Abstract of Pharmacology and Treatment

Received: March 24, 1997
Accepted: July 24, 1997
Published online: October 06, 2009

Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 0

ISSN: 1018-8665 (Print)
eISSN: 1421-9832 (Online)

For additional information: https://www.karger.com/DRM