A Vestigial X Open Reading Frame in Duck Hepatitis B VirusLin B. · Anderson D.A.
Macfarlane Burnet Centre for Medical Research, Fairfield, Melbourne, Australia
Dr. David Anderson
Head, Hepatitis Research Unit, Macfarlane Burnet Centre for Medical Research
Yarra Bend Road, Fairfield, Vic. 3078 (Australia)
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Duck hepatitis B virus (DHBV) appears to lack a homologue of the X protein found in mammalian hepadnaviruses. By replacing stop codons in the corresponding region of the DHBV genome, a hypothetical protein which closely matches the hydrophilicity profile of X proteins can be predicted, despite limited sequence homology. We conclude that a full-length X protein was once a common feature of the hepadnaviruses, conserved in structure but not sequence.
© 2000 S. Karger AG, Basel
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