The effects of restricting daily water intake to either a 30-min morning or evening period were investigated on: (1) the overall circadian pattern of adrenocortical activity, and (2) adrenocortical activity during the 20-min period immediately after water presentation. Morning water restriction produced a substantial increase in pre-water levels of circulating corticosterone without affecting evening levels, thereby changing the form of the circadian pattern. In contrast, evening water restriction did not elicit any pre-water increase in corticosterone levels, and there was no change in the circadian pattern. Both morning and evening water restricted animals showed a pronounced and rapid decline in corticosterone levels during the 20-min post-water period, with levels dropping by more than 50% within 10 min of water presentation. The dissociation of the pre-water elevation and post-water decline in corticosterone evident in evening water animals indicates that these 2 processes may be governed by different factors. It is suggested that the pre-water effect involves circadian regulatory mechanisms whereas the post-water effect is associated with the process of reinforcement.

This content is only available via PDF.
Copyright / Drug Dosage / Disclaimer
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.
You do not currently have access to this content.