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Hum Hered 1999;49:154–158

The LWb Blood Group as a Marker of Prehistoric Baltic Migrations and Admixture

Sistonen P.a · Virtaranta-Knowles K.a · Denisova R.b · Kučinskas V.c · Ambrasiene D.c · Beckman L.d

Author affiliations

aFinnish Red Cross Transfusion Service, Helsinki, Finland, bInstitute of History of Latvia, Riga, Latvia, cCenter of Human Genetics, Vilnius University, Vilnius, Lithuania, and dDepartment of Medical Genetics, Umeå, Sweden

Corresponding Author

Prof. Lars Beckman

Department of Medical Genetics

Umeå University

S–901 85 Umeå (Sweden)

Tel. +46 90 785 1769, Fax +46 90 785 3593

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Archaeological findings and historical records indicate frequent migrations and exchange of genetic material between populations in the Baltic Sea area. However, there have so far been very few attempts to trace migrations in this area using genetic markers. We have studied the Baltic populations with respect to exceptional variations in the frequencies of the Landsteiner-Wiener (LW) blood group. The frequency of the uncommon LWb gene was high in the Balts, around 6% among Latvians and Lithuanians, very low among the other western Europeans (0–0.1%) and apparently absent in Asiatic and African populations. From the Baltic region of peak frequency there was a regular decline of LWb incidence (a descending cline) in the neighboring populations: 4.0% in the Estonians, 2.9% in the Finns, 2.2% in the Vologda Russians, and 2.0% in the Poles. Thus the distribution of LWb suggests considerable and extensive Baltic admixture, especially in the north and northeast direction. In Southern Sweden with an LWb frequency of 0.3%, the Baltic influence appeared slight, while in the population of the Swedish island Gotland in the middle of the Baltic Sea there was a significantly incrased LWb frequency of 1.0% compared with that of Western European countries. The distinction of codominantly inherited LW antigenic forms, LWa and LWb (previously Nea), is known to be due to a single base substitution. Based on our population data, it is plausible that the expansion of this point mutation occurred only once during human history. Furthermore, our data indicate that the expansion of the LWb mutation occurred in Balts and that LWb can be considered a ‘Baltic tribal marker’, its presence in other populations being an indicator of the degree of Baltic genetic influence.


  1. Mourant AE, Kopec A, Domaniewska-Sobczak K: The distribution of the human blood groups and other polymorphisms. London, Oxford University Press, 1976.
  2. Tonnesson K (ed): Norden og Baltikum. Rapport I. 22. Nordiske historikermöte, Oslo 1994.
  3. Beckman L: A contribution to the physical anthropology and population genetics of Sweden. Variations of the AB0, Rh, MN and P blood groups. Hereditas 1959;45:1–189.
  4. Nevanlinna HR: The Finnish population structure. A genetic and genealogical sutdy. Hereditas 1972;71:195–236.
    External Resources
  5. Heapost L: A population-genetic characterization of the Estonians; in Populations of the Nordic countries. Human population biology from the present to the Mesolithic. Proc 2nd Semin Nordic Physical Anthropology, Lund 1990, pp 216–225.
  6. Beckman L, Kallstenius P: Blood groups of Estonians, A1A2B0 and Rh. J Hered 1959;6:287–289.
  7. Viikma M, Heapost L: Genetic differentiation of Estonians. Proc Estonian Acad Sci Biol 1996;45:128–136.
  8. Česnys G: The medieval Lithuanians according to craniological data/Multivariate analysis; in Populations of the Nordic countries. Human population biology from the present to the Mesolithic. Proc 2nd Semin Nordic Physical Anthropology, Lund 1990, pp 145–151.
  9. Sistonen P: The LW (Landsteiner Wiener) blood group system. Elucidation of the genetics of the LW blood group based on the finding of a ‘new’ blood group system, thesis, Helsinki, 1984.
  10. Hermand P, Gane P, Mattei MG, Sistonen P, Cartron J-P, Bailly P: Molecular basis and expression of the LW(a)/LW(b) blood group polymorphism. Blood 1995;86:1590–1594.
  11. Sistonen P: Linkage of the LW blood group locus with the complement C3 and Lutheran blood group loci. Ann Hum Genet 1984;48:239–242.
  12. Sistonen P, Tippett P: A ‘new’ allele giving further insight into the LW blood group system. Vox Sang 1982;42:252–255.
    External Resources
  13. Schneider S, Kueffer J-M, Roessli D, Excofiec L: Arlequin: A software for population genetic data analysis. Ver 1.1. Genetics and Biometry Lab Dept of Anthropology, University of Geneva, 1997.
  14. Sistonen P, Green CA, Lomas CG, Tippett P: Genetic polymorphism of the LW blood group system. Ann Hum Genet 1983;47:277–284.
  15. Sistonen P, Koistinen J, AdenAbdulle O: Distribution of blood groups in the East African Somali population. Hum Hered 1987;37:300–313.
    External Resources
  16. Suhonen S: On the distribution and semantic features of Baltic loan-words in the Finnic languages. Bidrag till kännedom om Finlands natur och folk, Helsinki, 1984, vol 131.

Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: May 31, 1999

Number of Print Pages: 5
Number of Figures: 1
Number of Tables: 2

ISSN: 0001-5652 (Print)
eISSN: 1423-0062 (Online)

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