A Comparison of the Short-Term Outcome in Patients with Acute Low-Tone Sensorineural Hearing LossMorita S. · Suzuki M. · Iizuka K.
Department of Otolaryngology, Kushiro City General Hospital, Kushiro, Japan
Department of Otolaryngology
Kushiro City General Hospital
1-12 Shunkodai, Kushiro, Hokkaido 085-0822 (Japan)
Tel. +81 154 41 6121, Fax +81 154 41 4080, E-Mail firstname.lastname@example.org
Do you have an account?
Purpose of the Study: We aimed to compare the short-term outcome of patients with acute low-tone sensorineural hearing loss (ALHL) treated with steroid alone, diuretics alone or combination treatment. Procedures: Between April 2000 and March 2009, we retrospectively reviewed the medical records of 156 patients with a diagnosis of ALHL. All patients were followed up until improvement or for 8 weeks from the initial examination. Patients were treated with steroid alone (n = 49), diuretics alone (n = 40), combination treatment (n = 46) or they received neither steroid nor diuretics (n = 21). Results: The steroid-diuretic combination therapy for ALHL showed significantly better results than the steroid or diuretic treatments alone (p < 0.05). There were no clinically significant differences in the outcome between the steroid- and diuretic-alone treatments. Conclusion and Message: The etiology of ALHL is described as both an endolymphatic hydrops and an autoimmunological mechanism so that, as expected, the steroid-diuretic combination therapy was more effective than the steroid or diuretic treatments alone.
© 2010 S. Karger AG, Basel
Abe T: Acute sensorineural hearing loss in low tone frequencies. Otolaryngology (Tokyo) 1982;54:385–392.
- Imamura S, Nozawa I, Imamura M, Murakami Y: Clinical observations on acute low-tone sensorineural hearing loss: survey and analysis of 137 patients. Ann Otol Rhinol Laryngol 1997;106:746–750.
- Yamasoba T, Sugasawa M, Kikuchi S, Yagi M, Harada T: An electrocochleographic study of acute low-tone sensorineural hearing loss. Eur Arch Otorhinolaryngol 1993;250:418–422.
- Fuse T, Hayashi T, Oota N, Fukase S, Asano S, Kato T, Aoyagi M: Immunological responses in acute low-tone sensorineural hearing loss and Ménière’s disease. Acta Otolaryngol 2003;123:26–31.
- Fuse T, Aoyagi M, Funakubo T, Sakakibara A, Yoshida S: Short-term outcome and prognosis of acute low-tone sensorineural hearing loss by administration of steroid. ORL J Otorhinolaryngol Relat Spec 2002;64:6–10.
- Nozawa I, Imamura S, Mizukoshi A, Honda H, Okamoto Y: Clinical study of acute low-tone sensorineural hearing loss: survey and analysis of glycerol test and orthostatic test. Ann Otol Rhinol Laryngol 2002;111:160–164.
- Tomiyama S: Endolymphatic hydrops induced by immune response of the endolymphatic sac: relation perilymph antibody levels. Ann Otol Rhinol Laryngol Suppl 1992;157:48–53.
- McCabe BF: Autoimmune sensorineural hearing loss. Ann Otol Rhinol Laryngol 1979;88:585–590.
- Parnes LS, Sun AH, Freeman DJ: Corticosteroid pharmacokinetics in the inner ear fluids: an animal study followed by clinical application. Laryngoscope 1999;109:1–17.
- Ruckenstein MJ, Milburn M, Hu L: Strial dysfunction in the MRL-Faslpr mouse. Otolaryngol Head Neck Surg 1999;121:452–456.
- Lin DW, Trune DR: Breakdown of stria vascularis blood-labyrinth barrier in CH3/lpr autoimmune disease mice. Otolaryngol Head Neck Surg 1997;117:530–534.
- Gross ND, Kempton JB, Trune DR: Spironolactone blocks glucocorticoid-mediated hearing preservation in autoimmune mice. Laryngoscope 2002;112:298–303.
- Chandrasekhar SS, Rubinstein RY, Kwartler JA, Gatz M, Connelly PE, Huang E, Baredes S: Dexamethasone pharmacokinetics in the inner ear: comparison of route of administration and use of facilitating agents. Otolaryngol Head Neck Surg 2000;122:521–528.
- Shea JJ, Ge X: Dexamethasone perfusion of the labyrinth plus intravenous dexamethasone for Ménière’s disease. Otolaryngol Clin North Am 1996;29:353–358.
- Silverstein H, Choo D, Rosenberg SI, Kuhn J, Seidman M, Stein I: Intratympanic steroid treatment of inner ear disease and tinnitus (preliminary report). Ear Nose Throat J 1996;75:468–488.
- Selivanova OA, Gouveris H, Victor A, Amedee RG, Mann W: Intratympanic dexamethasone and hyaluronic acid in patients with low-frequency and Ménière’s-associated sudden sensorineural hearing loss. Otol Neurotol 2005;26:890–895.
- Arriaga MA, Goldmann S: Hearing results of intratympanic steroid treatment of endolymphatic hydrops. Laryngoscope 1998;108:1682–1685.