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Gynecol Obstet Invest 2013;75:109-114

Short-Term Effects of High-Dose Khat on Sperm Parameters and Reproductive Hormonal Levels in Olive Baboons (Papio anubis)

Nyachieo A.a · Kiraithe M.M.a · Spiessens C.b · Chai D.C.a · Kiulia N.M.a · D'Hooghe T.M.a, b · Mwenda J.M.a

Author affiliations

aDepartment of Reproductive Health and Biology, Institute of Primate Research, Nairobi, Kenya; bLeuven University Fertility Centre, University Hospital Gasthuisberg, Leuven, Belgium

Corresponding Author

Dr. Jason M. Mwenda

Department of Reproductive Health and Biology

Institute of Primate Research, PO Box 24481

Karen, Nairobi 00502 (Kenya)

E-Mail jmmathiu@yahoo.co.uk

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The biological effects of khat (Catha edulis) on reproduction and fertility are inadequately investigated and controversial, hence we determined the effects of oral administration of high-dose khat on sperm parameters and male hormonal levels in olive baboons. In this study, 6 male baboons received a high dose of khat (500 g/week) during 1 month. Electroejaculation for sperm studies (concentration, motility and chromatin integrity) and plasma collection for hormonal analysis (testosterone, prolactin and cortisol) were done weekly during 1 month before and 1 month during khat administration as well as 2 weeks after the last dose of khat administration. Administration of khat extract induced a significant reduction in sperm motility (p = 0.008), sperm count (p = 0.041), sperm chromatin integrity (p = 0.0003), testosterone levels (p = 0.035) and prolactin levels (p = 0.0115), but not in cortisol levels and sperm volume (p > 0.05). The results suggest that high-dose khat decreases sperm quality and testosterone and hence may contribute to male infertility.

© 2012 S. Karger AG, Basel


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Article / Publication Details

First-Page Preview
Abstract of Original Article

Received: December 08, 2011
Accepted: October 17, 2012
Published online: December 11, 2012

Number of Print Pages: 6
Number of Figures: 2
Number of Tables: 1

ISSN: 0378-7346 (Print)
eISSN: 1423-002X (Online)

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