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Acta Cytologica 2013;57:198–202

Xanthogranuloma of Bone: A Challenging Imitator of Malignancy

Holmes B.J.a · Castelino-Prabhu S.a · Rosenthal D.L.a · Ali S.Z.a, b

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Departments of aPathology and bRadiology, The Johns Hopkins Hospital, Baltimore, Md., USA

Corresponding Author

Correspondence to: Dr. Syed Z. Ali

Department of Pathology, The Johns Hopkins Hospital

600 North Wolfe Street, Pathology Building, Room 406

Baltimore, MD 21287 (USA)

E-Mail sali@jhmi.edu

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Xanthogranulomatous disease of bone is exceptionally uncommon. Clinically, radiologically and pathologically, it is a great imitator of malignancy. While there are few reports on the surgical pathology of this rare entity, there is no published report on its cytopathologic characteristics. We report herein the case of a 44-year-old male who was evaluated at The Johns Hopkins Hospital for a 2.3-cm painful soft tissue mass present within the medullary canal of the distal tibia with destruction of the overlying cortex. A computed tomography-guided fine needle aspiration biopsy revealed abundant histiocytes and occasional giant cells in an inflammatory background. This was interpreted as a ‘histiocyte-rich lesion,’ and an excisional biopsy was recommended. Subsequent curettage was performed, and the histological material was diagnosed as ‘xanthogranuloma of bone.’ The rarity of xanthogranuloma of bone and its resemblance to the more common reactive and malignant bone neoplasms may present diagnostic challenges.

© 2013 S. Karger AG, Basel

Article / Publication Details

First-Page Preview
Abstract of Novel Insights from Clinical Practice

Received: September 04, 2012
Accepted: November 13, 2012
Published online: February 28, 2013

Number of Print Pages: 5
Number of Figures: 6
Number of Tables: 0

ISSN: 0001-5547 (Print)
eISSN: 1938-2650 (Online)

For additional information: http://www.karger.com/ACY

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