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Skin Pharmacol Physiol 2013;26:243-253

Passive and Iontophoretic Transport through the Skin Polar Pathway

Li S.K.a · Peck K.D.b

Author affiliations

aDivision of Pharmaceutical Sciences, James L. Winkle College of Pharmacy, University of Cincinnati, Cincinnati, Ohio, and bDepartment of Chemistry, Brigham Young University-Idaho, Rexburg, Idaho, USA

Corresponding Author

S. Kevin Li

Division of Pharmaceutical Sciences, James L. Winkle College of Pharmacy

University of Cincinnati, 3225 Eden Avenue, 136 HPB

Cincinnati, OH 45267-0004 (USA)

E-Mail kevin.li@uc.edu

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The purpose of the present article is to briefly recount the contributions of Prof. William I. Higuchi to the area of skin transport. These contributions include developing fundamental knowledge of the barrier properties of the stratum corneum, mechanisms of skin transport, concentration gradient across skin in topical drug applications that target the viable epidermal layer, and permeation enhancement by chemical and electrical means. The complex and changeable nature of the skin barrier makes it difficult to assess and characterize the critical parameters that influence skin permeation. The systematic and mechanistic approaches taken by Dr. Higuchi in studying these parameters provided fundamental knowledge in this area and had a measured and lasting influence upon this field of study. This article specifically reviews the validation and characterization of the polar permeation pathway, the mechanistic model of skin transport, the influence of the dermis on the target skin concentration concept, and iontophoretic transport across the polar pathway of skin including the effects of electroosmosis and electropermeabilization.

© 2013 S. Karger AG, Basel

Article / Publication Details

First-Page Preview
Abstract of  

Received: November 13, 2012
Accepted: January 31, 2013
Published online: July 29, 2013

Number of Print Pages: 11
Number of Figures: 8
Number of Tables: 0

ISSN: 1660-5527 (Print)
eISSN: 1660-5535 (Online)

For additional information: http://www.karger.com/SPP

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