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Ophthalmic Res 2018;59:88–97
(DOI:10.1159/000481262)

Multimodal Evaluation of the Fellow Eye of Patients with Retinal Angiomatous Proliferation

Martins A.a · Farinha C.a-c · Raimundo M.a · Lopes M.b · Santos A.R.b · Melo P.b · Marques M.a · Marques J.P.a-c · Barreto P.b · Cachulo M.L.a-c · Neves C.b · Cunha-Vaz J.b, c · Silva R.a-c

Author affiliations

aOphthalmology Department, Centro Hospitalar e Universitário de Coimbra, bAssociation for Innovation and Biomedical Research on Light and Image, and cFaculty of Medicine, Institute for Biomedical Imaging and Life Sciences (FMUC-IBILI), University of Coimbra, Coimbra, Portugal

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: August 31, 2017
Accepted: August 31, 2017
Published online: October 25, 2017

Number of Print Pages: 10
Number of Figures: 7
Number of Tables: 3

ISSN: 0030-3747 (Print)
eISSN: 1423-0259 (Online)

For additional information: https://www.karger.com/ORE

Abstract

Introduction: We conducted a multimodal, cross-sectional evaluation. Methods: Eyes were divided into 4 study groups: controls, early/intermediate age-related macular degeneration (AMD), fellow eyes of retinal angiomatous proliferation (RAP), and RAP eyes. Patients were evaluated with spectral-domain optical coherence tomography (OCT), enhanced depth imaging-OCT, and OCT angiography (OCTA). OCTA images were processed to generate maps of the vessel density and perfusion density of the superficial and deep retinal layers (SRL and DRL) and the choriocapillaris level (CL). The thickness of the outer nuclear layer and choroid was manually assessed. Results: We included 135 eyes of 100 patients (51 controls, 30 AMD, 42 RAP, and 12 fellow eyes). The fellow eyes showed a significantly lower vascular perfusion of the SRL, DRL, and CL (p < 0.02) than the early/intermediate AMD and control eyes did. Similarly, RAP eyes presented a lower vascular perfusion of the DRL and CL (p < 0.05). Besides, structural analyses of the fellow eyes and RAP eyes revealed a significantly higher prevalence of macular pigmentary changes, atrophy of the retinal pigment epithelium, hyperreflective “clumps” above flat drusen, amongst others, than early/intermediate AMD and control eyes (p < 0.05). Conclusion: We present the first report on the OCTA analysis of the fellow eye of patients with RAP. The reduced perfusion density and vessel density observed contributes, in association with clearly defined structural changes, to a wider characterization of RAP as a distinctive phenotype.

© 2017 S. Karger AG, Basel



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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: August 31, 2017
Accepted: August 31, 2017
Published online: October 25, 2017

Number of Print Pages: 10
Number of Figures: 7
Number of Tables: 3

ISSN: 0030-3747 (Print)
eISSN: 1423-0259 (Online)

For additional information: https://www.karger.com/ORE

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2018, Vol.59, No. 2

February 2018

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