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Dement Geriatr Cogn Disord 2003;15:132–142

Kinematic Analysis of Handwriting Movements in Patients with Alzheimer’s Disease, Mild Cognitive Impairment, Depression and Healthy Subjects

Schröter A. · Mergl R. · Bürger K. · Hampel H. · Möller H.-J. · Hegerl U.

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Department of Psychiatry, Ludwig Maximilian University Munich, Munich, Germany

Corresponding Author

Dipl.-Psych. Andreas Schröter

Psychiatrische Klinik und Poliklinik der Ludwig-Maximilians-Universität München

Nussbaumstrasse 7, D–80336 München (Germany)

Tel. +49 89 5160 5866, Fax +49 89 5160 5875

E-Mail schroete@nk-i.med.uni-muenchen.de

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A variety of studies have demonstrated that motor disorders, parkinsonism and extrapyramidal motor symptoms (EPMS) are common in patients with Alzheimer’s disease (AD). Several studies have reported an association of EPMS with severity, progression and poor prognosis of AD. The majority of these studies used clinical assessments for the rating of EPMS. In this study, kinematic handwriting analysis was used to quantify differences in fine hand motor function in patients with probable AD and mild cognitive impairment (MCI, as an assumed initial stage of AD) compared to depressed patients and healthy controls. Both patients with MCI and patients with probable AD exhibited loss of fine motor performance. Movements of AD patients were significantly less regular than those of healthy controls.

© 2003 S. Karger AG, Basel


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Article / Publication Details

First-Page Preview
Abstract of Original Research Article

Received: September 23, 2002
Published online: February 19, 2003

Number of Print Pages: 11
Number of Figures: 5
Number of Tables: 5

ISSN: 1420-8008 (Print)
eISSN: 1421-9824 (Online)

For additional information: https://www.karger.com/DEM