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Dermatology 2003;206:316–320

A Randomized, Double-Blind, Placebo-Controlled Trial of Vitamin C Iontophoresis in Melasma

Huh C.-H.a · Seo K.-I.b · Park J.-Y.a · Lim J.-G.a · Eun H.-C.a · Park K.-C.a

Author affiliations

aDepartment of Dermatology, Seoul National University College of Medicine, and bModelo Clinic, Seoul, Korea

Corresponding Author

Prof. Kyung-Chan Park, MD, PhD

Department of Dermatology, Seoul National University College of Medicine

28, Yongon-dong, Chongno-gu

Seoul 110-744 (Korea)

Tel. +82 2 3668 7474, Fax +82 2 742 7344, E-Mail gcpark@snu.ac.kr

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Background: Vitamin C is known to both inhibit melanin formation and reduce oxidized melanin. However, vitamin C does not easily penetrate the skin. In this study, vitamin C iontophoresis was employed in order to enhance vitamin C penetration. Objective: The purpose of this study was to evaluate the efficacy of vitamin C iontophoresis for melasma patients. Methods: Twenty-nine females with melasma were enrolled. For iontophoresis, a vitamin C solution was applied to one side of the face, while distilled water was applied to the other side as a control. The L (luminance) value was measured by a colorimeter to obtain an objective pigmentation parameter. Results: Twelve weeks after iontophoresis, the colorimeter of the treated site showed a significant decrease in the L value (from 4.60 to 2.78, p = 0.002), compared to that of the control site (from 4.45 to 3.87, p = 0.142). Conclusion: Vitamin C iontophoresis may be an effective treatment modality for melasma.

© 2003 S. Karger AG, Basel


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Article / Publication Details

First-Page Preview
Abstract of Pharmacology and Treatment

Received: January 08, 2002
Accepted: October 05, 2002
Published online: June 13, 2003

Number of Print Pages: 5
Number of Figures: 5
Number of Tables: 1

ISSN: 1018-8665 (Print)
eISSN: 1421-9832 (Online)

For additional information: https://www.karger.com/DRM