A Randomized, Double-Blind, Placebo-Controlled Trial of Vitamin C Iontophoresis in MelasmaHuh C.-H.a · Seo K.-I.b · Park J.-Y.a · Lim J.-G.a · Eun H.-C.a · Park K.-C.a
aDepartment of Dermatology, Seoul National University College of Medicine, and bModelo Clinic, Seoul, Korea
Prof. Kyung-Chan Park, MD, PhD
Department of Dermatology, Seoul National University College of Medicine
28, Yongon-dong, Chongno-gu
Seoul 110-744 (Korea)
Tel. +82 2 3668 7474, Fax +82 2 742 7344, E-Mail firstname.lastname@example.org
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Background: Vitamin C is known to both inhibit melanin formation and reduce oxidized melanin. However, vitamin C does not easily penetrate the skin. In this study, vitamin C iontophoresis was employed in order to enhance vitamin C penetration. Objective: The purpose of this study was to evaluate the efficacy of vitamin C iontophoresis for melasma patients. Methods: Twenty-nine females with melasma were enrolled. For iontophoresis, a vitamin C solution was applied to one side of the face, while distilled water was applied to the other side as a control. The L (luminance) value was measured by a colorimeter to obtain an objective pigmentation parameter. Results: Twelve weeks after iontophoresis, the colorimeter of the treated site showed a significant decrease in the L value (from 4.60 to 2.78, p = 0.002), compared to that of the control site (from 4.45 to 3.87, p = 0.142). Conclusion: Vitamin C iontophoresis may be an effective treatment modality for melasma.
© 2003 S. Karger AG, Basel
Lerner AB, Fitzpatrick TB: Biochemistry of melanin formation. Physiol Rev 1950;30:91–126.
Ros JR, Rodriguez-Lopes JN, Garcia-Canovas F: Effect of L-ascorbic acid on the monophelase activity of tyrosinase. Biochem J 1993;295:309–312.
Nomura H, Ishiguro T, Morimoto S: Studies on L-ascorbic acid derivatives. II. L-Ascorbic acid and 3-phosphate and 3-pyrophosphate. Chem Pharm Bull (Tokyo) 1989;17:381–386.
- Kameyama K, Sakai C, Kondoh S, Yonemoto K, Nishiyama S, Tagawa M, Murata T, Ohnuma T, Quigley J, Dorsky A, Bucks D, Blanock K: Inhibitory effect of magnesium L-ascorbyl-2-phosphate (VC-PMG) on melanogenesis in vitro and in vivo. J Am Acad Dermatol 1996;34:29–33.
Westerhof W: CIE Colorimetry; in Serup J, Jemec GBE (eds): Handbook of Noninvasive Methods and the Skin. Boca Raton, CRC Press, 1995, pp 385–397.
Mosher DB, Fitzpatrick TB, Ortonne JP, Hori Y: Hypomelanoses and hypermelanoses; in Freedberg IM, Eisen AZ, Wolff K, Austen KF, Goldsmith LA, Katz SI, Fitzpatrick TB (eds): Dermatology in General Medicine, ed 5. New York, McGraw-Hill, 1999, pp 996–997.
Jimbow K, Minamitsuji Y: Topical therapies for melasma and disorders of hyperpigmentation. Dermatol Ther 2001;14:35–45.
- Grimes PE: Melasma: Etiologic and therapeutic considerations. Arch Dermatol 1995;131:1453–1457.
Piamphongsant T: Treatment of melasma: A review with personal experience. Int J Dermatol 1998;37:897–903.
- Lee SH, Choi EH, Feingold KR, Jiang S, Ahn SK: Iontophoresis itself on hairless mouse skin induces the loss of the epidermal calcium gradient without skin barrier impairment. J Invest Dermatol 1998;111:39–43.
Green PG, Flanagan M, Shroot B, Guy RH: Iontophoretic drug delivery; in Walkers KA, Hadgraft J (eds): Pharmaceutical Skin Penetration Enhancement. New York, Dekker, 1993, pp 311–333.
- Chien YW, Siddiqui O, Shi WM, Lelawongs P, Liu JC: Direct current iontophoretic transdermal delivery of peptide and protein drugs. J Pharm Sci 1989;78:376–384.
- Grimmes S: Pathways of ionic flow through human skin in vivo. Acta Derm Venereol (Stockh) 1984;64:93–98.
Suzuki H: Skin lightening with iontophoresis of L-ascorbic acid-2-phosphate (in Japanese). J Jpn Soc Aesthet Plast Surg 1998;20:46–67.