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Neuroendocrinology 2004;80(suppl 1):3–7

Epidemiology of Neuroendocrine Tumours

Taal B.G.a · Visser O.b

Author affiliations

aDepartment of Gastroenterology, Netherlands Cancer Institute/Antoni van Leeuwenhoek Hospital and bComprehensive Cancer Centre Amsterdam, Amsterdam, The Netherlands

Corresponding Author

B.G. Taal

Netherlands Cancer Institute/Antoni van Leeuwenhoek Hospital

Plesmanlaan 121

NL–1066 CX Amsterdam (The Netherlands)

Tel. +31 20 5122566, Fax +31 20 5122578, E-Mail b.taal@nki.nl

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Neuroendocrine tumours account for only 0.5% of all malignancies. The incidence is approximately 2/100,000 with a female preponderance under the age of 50 years due to appendiceal location. The main primary sites are the gastrointestinal tract (62–67%) and the lung (22–27%). Presentation with metastatic disease accounts for 12–22%. In the last decades, the incidence has been rising. This might be due to more awareness, improved diagnostic tools or a change in definition. Most neuroendocrine tumours are mainly sporadic, but association with the multiple endocrine neoplasia type 1 syndrome and clustering within families is known. Also an increased risk of secondary cancers has been reported, but numbers are small. The 5-year survival is mainly associated with stage: 93% in local disease, 74% in regional disease and 19% in metastatic disease. In metastatic disease, survival increased since 1992, when treatment with octreotide became largely available in the Netherlands.

© 2004 S. Karger AG, Basel

Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: October 15, 2004

Number of Print Pages: 5
Number of Figures: 2
Number of Tables: 2

ISSN: 0028-3835 (Print)
eISSN: 1423-0194 (Online)

For additional information: http://www.karger.com/NEN

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