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Skin Pharmacol Appl Skin Physiol 2006;19:224–231

Antioxidant Supplements Improve Parameters Related to Skin Structure in Humans

Heinrich U.a · Tronnier H.a · Stahl W.b · Béjot M.c · Maurette J.-M.c

Author affiliations

aInstitute of Experimental Dermatology, University of Witten/Herdecke, Witten, bInstitute of Biochemistry and Molecular Biology I, University of Düsseldorf, Düsseldorf, Germany, and cLaboratoire Oenobiol, Paris, France

Corresponding Author

Prof. Dr. Ulrike Heinrich

Institut für Experimentelle Dermatologie, Universität Witten/Herdecke

Alfred-Herrhausen-Strasse 44 (FEZ)

DE–58455 Witten (Germany)

Tel. +49 2302 2826 300, Fax +49 2302 2826 326, E-Mail ulrike.heinrich@uni-wh.de

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In the present study we investigated the influence of two different antioxidant supplements composed of carotenoids, vitamin E and selenium on parameters related to skin health and skin aging. Thirty-nine volunteers with healthy, normal skin of skin type 2 were divided into 3 groups (n = 13) and supplemented for a period of 12 weeks. Group 1 received a mixture of lycopene (3 mg/day), lutein (3 mg/day), β-carotene (4.8 mg/day), α-tocopherol (10 mg/day) and selenium (75 µg/day). Group 2 was supplemented with a mixture of lycopene (6 mg/day), β-carotene (4.8 mg/day), α-tocopherol (10 mg/day) and selenium (75 µg/day). Group 3 was the placebo control. Upon supplementation serum levels of selected carotenoids increased in both verum groups. Skin density and thickness were determined by ultrasound measurements. A significant increase for both parameters was determined in the verum groups. Roughness, scaling, smoothness and wrinkling of the skin were determined by Surface Evaluation of Living Skin (Visioscan). Roughness and scaling were improved by the supplementation with antioxidant micronutrients. In the placebo group no changes were found for any of the parameters.

© 2006 S. Karger AG, Basel


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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: July 12, 2005
Accepted: October 14, 2005
Published online: July 14, 2006

Number of Print Pages: 8
Number of Figures: 4
Number of Tables: 4

ISSN: 1660-5527 (Print)
eISSN: 1660-5535 (Online)

For additional information: https://www.karger.com/SPP