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Skin Pharmacol Appl Skin Physiol 2006;19:329–335
(DOI:10.1159/000095253)

In vitro 5-Lipoxygenase and Anti-Oxidant Activities of South African Medicinal Plants Commonly Used Topically for Skin Diseases

Frum Y.a · Viljoen A.M.b

Author affiliations

aDepartment of Pharmacy and Pharmacology, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, and bSchool of Pharmacy, Faculty of Health Sciences, Tshwane University of Technology, Pretoria, South Africa

Corresponding Author

Alvaro M. Viljoen, PhD

School of Pharmacy, Tshwane University of Technology

Private Bag X680

Pretoria 0001 (South Africa)

Tel. +27 12 318 6360, Fax +27 12 318 6243, E-Mail viljoenam@tut.ac.za

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Abstract

An investigation was undertaken to determine the possible mechanisms of action of medicinal plants used for dermatological pathologies. A total of 14 plant species were selected from the readily available ethnobotanical literature. 5-Lipoxygenase and DPPH (2,2-diphenyl-1-picrylhydrazyl) assays were used to determine the anti-inflammatory activity and the anti-oxidant activity of selected medicinal plants, respectively. Both aqueous and methanol extracts were tested. Among the plants screened, four species (Croton sylvaticus, Warburgia salutaris, Pentanisia prunelloides, and Melianthus comosus) displayed promising 5-lipoxygenase inhibitory activity with IC50 values <61 ppm. A large number of plants exhibited significant anti-oxidant activities with IC50 values between 5.27 and 83.36 ppm. Aqueous extracts of M. comosus exhibited the most potent anti-inflammatory and anti-oxidant activity.

© 2006 S. Karger AG, Basel


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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: March 11, 2005
Accepted: February 17, 2006
Published online: November 24, 2006

Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 1

ISSN: 1660-5527 (Print)
eISSN: 1660-5535 (Online)

For additional information: https://www.karger.com/SPP